LC Cancer Research Results

LC, Local control: Click to Expand ⟱
Source:
Type:

local control
Scientific Papers found: Click to Expand⟱
7650- HPT,    Hyperthermia and radiation therapy for locally advanced or recurrent breast cancer
- Trial, BC, NA
OS↑, At a median follow-up of 13 months (mean 30±38), improved overall survival was significantly associated with increasing RT dose (p<0.0001), median TED 42.5°C≥200 minutes (p=0.003), and local control (p=0.0002).
LC↑,

7599- HPT,  Rad,    Recent development on hyperthermia: An effective cotreatment improving radiotherapy outcome
- Review, Var, NA
NA↑, As an adjunct to radiotherapy and chemotherapy, hyperthermia enhances the therapeutic efficacy against both primary and recurrent tumors.
RadioS↑, The present review explores the mechanisms underlying the synergy between radiotherapy and hyperthermia, while reviewing the outcomes of relevant clinical trials.
DNArepair↓, Key mechanisms of action include inhibition of DNA repair, reduction of hypoxic tumor cell populations, enhancement of drug uptake and improved perfusion and oxygenation.
Hypoxia↓,
EPR↑,
LC↑, Its application has improved both local control and overall survival (OS),
OS↑,
*toxicity↓, Randomized clinical trials (4–6) have demonstrated that combined therapy effectively prolongs disease-free survival and ensures local tumor control without added toxicity.
Dose↝, fever-range temperatures (39–40°C), moderate heating to induce cellular stress (41–43°C) and high-intensity thermal ablation >43°C for cell destruction.
BloodF↑, Hyperthermia is particularly toxic to cells in acidic environments (29), and increased blood flow helps clear acidic metabolites, restore normal extracellular pH
pH↝,
Imm↑, Under heat stress, tumor cells release heat shock protein 70 (HSP70), triggering antitumor immune responses
HSP70/HSPA5↑,

7598- HPT,  Rad,  Chemo,    The role of capacitive hyperthermia as an adjunct treatment in oncology: a systematic review of randomized phase III trials
- Review, Var, NA
OS↑, It has been demonstrated that the combination of cHT with either RT or CT may improve TR and LC and, in certain cases, OS when compared with RT with or without CT alone
TR↑,
LC↑,
*toxicity?, The occurrence of significant side effects is rare.

7622- HPT,    A Review of the Current Clinical Evidence for Loco-Regional Moderate Hyperthermia in the Adjunct Management of Cancers
- Review, Var, NA
LC↑, moderate RHT in improving local tumour control, survival outcomes and quality of life scores were observed across the different cancer subsites with minimal increase in toxicities.
OS↑,
QoL↑,
toxicity↓,
Dose↝, Various heating methods include direct (e.g., intracavitary and whole-body waterbed), infrared, perfusional (e.g., isolated limb perfusion, intravesical and intraperitoneal), nanoparticles, ultrasound and regional radiofrequency (RF) radiation
Dose↝, Moderate HT is usually described at a range of 39–44 °C a
ROS↑, Figure 1
DNArepair↓,
EPR↑,
DNAdam↑,
HSP70/HSPA5↑,
BloodF↑,
Hypoxia↓,


Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

LC↑, 4,   NA↑, 1,   TR↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   DNArepair↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

EPR↑, 2,   Hypoxia↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Imm↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 3,   RadioS↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 2,  

Functional Outcomes(tgid=23) ⓘ

OS↑, 4,   QoL↑, 1,   toxicity↓, 1,  
Total Targets: 17

Pathway results for Effect on Normal Cells:


Functional Outcomes(tgid=23) ⓘ

toxicity?, 1,   toxicity↓, 1,  
Total Targets: 2

Scientific Paper Hit Count for: LC, Local control
4 Hyperthermia
2 Radiotherapy/Radiation
1 Chemotherapy
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1668  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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