2/16-OHE1 Cancer Research Results

2/16-OHE1, 2-OHE1/16α-OHE1 Ratio/2-Hydroxyestrone to 16α-Hydroxyestrone Ratio: Click to Expand ⟱
Source:
Type:

2-OHE1/16α-OHE1 Ratio - 2-Hydroxyestrone to 16α-Hydroxyestrone Ratio

Abbreviation: 2/16-OHE1 ratio, 2-OHE1/16α-OHE1, EMR

Type: Estrogen metabolism biomarker / metabolite ratio

Function: Represents the relative metabolism of estrone through the 2-hydroxylation versus 16α-hydroxylation pathways. 2-Hydroxyestrone has relatively weak estrogenic activity, whereas 16α-hydroxyestrone has greater estrogenic and potentially genotoxic/proliferative activity.

Cancer: ↓ A lower 2-OHE1/16α-OHE1 ratio has historically been proposed to represent a less favorable estrogen-metabolism profile and potentially greater breast-cancer risk, while an increased ratio has been considered potentially favorable. However, prospective studies and systematic reviews have found inconsistent associations, and the ratio is not considered a validated predictor of breast-cancer risk.

Direction: ↑ Traditionally considered favorable, but clinical significance remains uncertain.
Scientific Papers found: Click to Expand⟱
7601- I3C,    Prevention and treatment of cancer with indole-3-carbinol
- Review, BC, NA
Estro↝, Oral administration of I-3-C has been shown to manipulate estrogen metabolism in humans in a possibly beneficial manner.
2/16-OHE1↑, I-3-C increases the 2/16-hydroxyestrone ratio, a ratio found to be predictive of breast cancer risk in some prospective studies.
chemoPv↑, A chemopreventive effect of I-3-C has been demonstrated in a number of animal models.

7602- I3C,    Dose-ranging study of indole-3-carbinol for breast cancer prevention
- Trial, BC, NA
toxicity↓, none of the women experienced any significant toxicity effects.
Dose↝, The results in this study suggest that I3C at a minimum effective dose schedule of 300 mg per day is a promising chemopreventive agent for breast cancer prevention
2/16-OHE1↑, The urinary estrogen metabolite ratio of 2-hydroxyestrone to 16 alpha-hydroxyestrone, as determined by an ELISA assay, served as the surrogate endpoint biomarker (SEB). SEB for women in the HD group was significantly greater than that for women in th
chemoPv↑,

7604- I3C,    Multifunctional aspects of the action of indole-3-carbinol as an antitumor agent
2/16-OHE1↑, shown that it induces CyP4501A1, increasing 2-hydroxylation of estrogens, leading to the protective 2-OHE1, and also decreases CyP1B1 sharply, inhibiting 4-hydroxylation of estradiol, thereby decreasing the formation of the carcinogenic 4-OHE1.
CYP1B1↓,
4-OHE1↓,
Apoptosis↑, indole-3-carbinol has been shown to have direct effects on apoptosis and cyclin D, resulting in blockage of the cell cycle.
cycD1/CCND1↓,
TumCCA↑,
AntiTum↑, In addition to its antitumor activity in animals, it has also been shown to be effective against HPV-mediated tumors in human patients

7606- I3C,    Altered estrogen metabolism and excretion in humans following consumption of indole-3-carbinol
- Human, Nor, NA
P450↝, Indole-3-carbinol (I3C), obtained from cruciferous vegetables (e.g., cabbage, broccoli, etc.), is a known inducer of oxidative P-450 metabolism in animals.
2/16-OHE1↑, estradiol 2-hydroxylation before and after exposure to I3C. In a group of 12 healthy volunteers, the average extent of reaction increased by approximately 50% during this short exposure

7611- I3C,    Long-term responses of women to indole-3-carbinol or a high fiber diet
- Trial, Nor, NA
*Dose↝, 20 subjects, arm 1 received 400 mg/day of I3C daily for 3 months, arm 2 received 20 g of alpha-cellulose daily for the same time period as a source of added fiber, and arm 3 received a placebo dose.
*2/16-OHE1↑, a substantial mean increase in the ratio was observed in the I3C-treated arm at month 1; that increase was maintained over the 3-month time period.


Showing Research Papers: 1 to 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

2/16-OHE1↑, 4,   4-OHE1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

CYP1B1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   TumCCA↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Estro↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,   P450↝, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,   chemoPv↑, 2,   toxicity↓, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

2/16-OHE1↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  
Total Targets: 2

Scientific Paper Hit Count for: 2/16-OHE1, 2-OHE1/16α-OHE1 Ratio/2-Hydroxyestrone to 16α-Hydroxyestrone Ratio
5 Indole-3-carbinol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1669  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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