CR Cancer Research Results

CR, Complete Response: Click to Expand ⟱
Source:
Type:
Scientific Papers found: Click to Expand⟱
7621- HPT,  Rad,    Clinical effectiveness of combined whole body hyperthermia and external beam radiation therapy (EBRT) versus EBRT alone in patients with painful bony metastases: A phase III clinical trial study
- Trial, Pca, NA - Trial, BC, NA
Pain↓, WBH plus RT showed significant increases in pain relief and shorter response time in comparison with RT-alone for patients with bone metastatic lesions.
Dose↝, WBH application time was 3-4 h in three fractions with at least 48-h intervals.
CR↑, Finally, the CR rate in RT + WBH revealed the most significant difference with RT-alone, 47.4% versus 5.3% respectively within 2 months post-treatment

7624- HPT,  Chemo,    A multicentre randomised clinical trial of chemoradiotherapy plus hyperthermia versus chemoradiotherapy alone in patients with locally advanced cervical cancer
- Trial, Cerv, NA
OS↑, Although not statistically significant, the 5-year OS, DFS and LRFS in the CRT + HT group (77.8%, 70.8% and 80.1%, respectively) were better than those in the CRT group (64.8%, 60.6% and 71.0%, respectively). C
CR↑, CR was significantly more likely to be achieved in patients in the CRT + HT group than in the CRT group (88% vs. 77.6%; adjusted odds ratio, 3.993; 95% confidence interval, 1.018-15.67; p = .047).
*toxicity↓, CRT + HT was well tolerated and caused no additional acute or long-term toxicity compared with CRT alone.

7627- HPT,  Rad,    Local control rate after the combination of re-irradiation and hyperthermia for irresectable recurrent breast cancer: Results in 248 patients
CR↑, CR rate was 70%. At 1, 3, and 5 years LC was 53%, 40% and 39%, and OS was 66%, 32%, and 18%, respectively.
OS↑, OS after 10 years was 10%.
*toxicity↝, Thermal burns developed in 23% patients, healing with conservative measures. T
RadioS↑, The combination of re-RT and HT results in a high rate of long-term LC with acceptable late toxicity, and many patients remained locally controlled for the rest of their survival period.


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

CR↑, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,   RadioS↑, 1,  

Functional Outcomes(tgid=23) ⓘ

OS↑, 2,   Pain↓, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,   toxicity↝, 1,  
Total Targets: 2

Scientific Paper Hit Count for: CR, Complete Response
3 Hyperthermia
2 Radiotherapy/Radiation
1 Chemotherapy
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1672  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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