TRAF2 Cancer Research Results

TRAF2, TNF Receptor Associated Factor 2: Click to Expand ⟱
Source:
Type:

TRAF2 - TNF Receptor Associated Factor 2

Type: Signaling adaptor / E3 ubiquitin ligase-associated protein

Function: TRAF2 is a signaling adaptor recruited by multiple TNF receptor superfamily members and forms complexes with proteins including cIAP1/BIRC2, cIAP2/BIRC3, RIPK1, and other signaling regulators. It controls NF-κB, JNK/MAPK, inflammatory, survival, apoptotic, and immune-signaling pathways through ubiquitination-dependent signaling complexes.

Cancer: ↑ Frequently increased or functionally overactive in cancer. TRAF2 can promote NF-κB and MAPK signaling, tumor-cell survival, proliferation, inflammation, resistance to apoptosis, and treatment resistance. Amplification or increased TRAF2 signaling has been reported in several malignancies, although its effects depend on receptor and downstream signaling context.
Scientific Papers found: Click to Expand⟱
7628- Ins,    Proteomic Analysis of Anticancer Effect of Myo-inositol in Human Prostate Cancer (DU-145) Cell Line
- in-vitro, Pca, DU145
tumCV↓, Myo-inositol significantly reduced DU-145 cell viability with an IC50 of 0.06 mg/ml (p<0.05).
annexin II↓, with suppression of proteins like Annexin A2 and Cofilin-1-A in controls, and upregulation of proteins such as Rho GTPase-activating protein, Apoptotic protease-activating factor 1 (APAF1), and TNF receptor-associated factor 2 (TRAF2)
Cofilin↓,
Rho↑,
APAF1↑,
TRAF2↑,
Apoptosis↑, Myo-inositol and its derivatives limit cell growth and trigger apoptosis in breast, colon, and prostate cancer cell lines via disturbed pathways like the PI3K/Akt pathway.
PI3K↓,
Akt↓,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

TRAF2↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   APAF1↑, 1,   Apoptosis↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PI3K↓, 1,  

Migration(tgid=13) ⓘ

annexin II↓, 1,   Cofilin↓, 1,   Rho↑, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: TRAF2, TNF Receptor Associated Factor 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1673  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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