AcOH Cancer Research Results

AcOH, Acetate/Acetic Acid: Click to Expand ⟱
Source:
Type:

Acetate - Acetic Acid

Abbreviation: Acetate, AcOH

Type: Short-chain fatty acid / metabolic and signaling metabolite

Function: Acetate is a two-carbon short-chain fatty acid produced by gut microbial fermentation and by endogenous metabolism. It can be converted to acetyl-CoA and thereby contribute to energy metabolism, lipid synthesis, protein acetylation, and epigenetic regulation. Acetate also participates in SCFA receptor signaling through receptors including FFAR2/GPR43 and FFAR3/GPR41.

Cancer: ↕ Context-dependent. Acetate can serve as a metabolic substrate for acetyl-CoA production, lipid synthesis, and histone acetylation in some tumors, potentially supporting growth under metabolic stress. However, SCFA signaling can also exert anti-inflammatory and growth-regulatory effects depending on tissue and metabolic context.

Alzheimer's Disease: ↕ Context-dependent. Acetate and other gut-derived SCFAs can influence neuroinflammation, gut-brain signaling, blood-brain barrier function, and cellular metabolism. Effects depend on concentration, tissue compartment, microbiome context, and overall SCFA balance.
Scientific Papers found: Click to Expand⟱
7664- IP,  GCL2505,    Administration of bifidobacteria and dietary fiber improves cognitive function by increasing short-chain fatty acid-producing bacteria and reducing inflammation
- Trial, AD, NA
*cognitive↑, A randomized, double-blind, placebo-controlled, parallel-group clinical trial of this probiotic strain in combination with inulin (a prebiotic) reported an improvement of cognitive function in the elderly.
*SCFAs↑, After probiotic and prebiotic administration, short-chain fatty acid producers such as Faecalibacterium and Bifidobacterium were increased in the gut.
*GutMicro↑, GCL2505 and inulin can improve cognitive function by alleviating inflammation via an increase of short-chain fatty acid-producing bacteria, which appears to elevate levels of short-chain fatty acids, particularly acetate and butyrate, in the gut.
*Buty↑,
*AcOH↑,
*neuroP↑, 12 weeks of administration of GCL2505 and inulin significantly improved scores in the Neurocognitive Index domain, an assessment of overall cognitive function,

7666- IP,    Short-chain fatty acid kinetics and concentrations are higher after inulin supplementation in young and older adults: a randomized trial
- Trial, Nor, NA
*Dose↝, placebo-controlled, double-blind crossover study, 21 YAs (20-29 y) and 40 OAs (59-87 y) adults were supplemented with inulin or placebo (maltodextrin) for 7 d (final intake: 30 g/d)
*Buty↑, Inulin evoked a 44% increase in butyrate production (μmol/min) in the inaccessible pool
*PA↑, In addition, a 34% increase in propionate production in YA only
*AcOH↑, We found a 50%-60% increase in fecal acetate, propionate, and butyrate and a 34% increase in plasma butyrate in OA, whereas in YA only 34% increase in fecal acetate.
*SCFAs↑, Inulin intake increases SCFA production.


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AcOH↑, 2,   Buty↑, 2,   PA↑, 1,   SCFAs↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

GutMicro↑, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 1,   neuroP↑, 1,  
Total Targets: 8

Scientific Paper Hit Count for: AcOH, Acetate/Acetic Acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1679  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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