6IL Cancer Research Results

6IL, 6-Iodolactone: Click to Expand ⟱
Source:
Type:

6-Iodolactone - 6-Iodo-5-Hydroxy-8,11,14-Eicosatrienoic Acid δ-Lactone

Alternative Names: 6-Iodolactone, 6IL, 6-iodo-5-hydroxy-8,11,14-eicosatrienoic acid δ-lactone

Type: Iodolipid / iodinated arachidonic-acid derivative / bioactive lipid metabolite

Formation: 6-IL is formed by iodination of arachidonic acid and has been detected in thyroid and mammary tissues following iodine exposure. Molecular iodine can increase 6-IL formation in tumor tissue containing elevated arachidonic acid.

Function: 6-Iodolactone is a bioactive iodolipid that mediates part of the antiproliferative and apoptotic effects of iodine. It acts as an activator of PPARγ and can regulate proliferation, differentiation, mitochondrial apoptosis, migration, and tumor-associated signaling.

Cancer: Preclinical studies demonstrate inhibition of tumor-cell proliferation and migration and induction of apoptosis. 6-IL activates PPARγ, and inhibition or knockdown of PPARγ substantially reduces its antiproliferative and pro-apoptotic effects. Antitumor activity has been demonstrated particularly in breast, thyroid, and prostate cancer models.
Scientific Papers found: Click to Expand⟱
7676- iod,    Antineoplastic effect of iodine in mammary cancer: participation of 6-iodolactone (6-IL) and peroxisome proliferator-activated receptors (PPAR)
- in-vivo, BC, NA
TumCP↓, Apoptosis↑, Dose↝, other↑, BloodF↓, VEGF↓, UroPA↓, PPARα↓, DR4↑, Casp3↑, PPARγ↑, antiNeop↑, Risk↓, 6IL↑,
7677- iod,    Activation of peroxisome proliferator-activated receptor gamma is crucial for antitumoral effects of 6-iodolactone
- in-vitro, BC, MCF7
TumCP↓, 6IL↑, PPARγ↑, AntiCan↑,
7678- iod,    Signaling pathways involved in the antiproliferative effect of molecular iodine in normal and tumoral breast cells: evidence that 6-iodolactone mediates apoptotic effects
- in-vitro, Nor, MCF12A - in-vitro, BC, MCF7
TumCCA↑, selectivity↑, 6IL↑, eff↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

6IL↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

PPARα↓, 1,   PPARγ↑, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   Casp3↑, 1,   DR4↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 2,   UroPA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,   eff↑, 1,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   antiNeop↑, 1,   Risk↓, 1,  
Total Targets: 18

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: 6IL, 6-Iodolactone
3 iodine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1680  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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