CLDN7 Cancer Research Results

CLDN7, claudin 7: Click to Expand ⟱
Source:
Type:

CLDN7 - Claudin-7

Abbreviation: CLDN7, Claudin-7

Type: Tight-junction transmembrane protein / epithelial adhesion and barrier protein

Function: Claudin-7 is a four-pass transmembrane protein of epithelial tight junctions that helps regulate paracellular permeability, epithelial polarity, cell-cell adhesion, and tissue barrier integrity. CLDN7 also influences epithelial-mesenchymal transition, migration, invasion, and signaling pathways including Wnt/β-catenin and adhesion-related signaling.

Cancer: ↕ Context-dependent. Loss or reduced CLDN7 expression occurs in several cancers and can disrupt epithelial adhesion, reduce E-cadherin, promote EMT, and increase invasion and metastasis. Conversely, CLDN7 is overexpressed in other tumors, including subsets of ovarian, gastric, pancreatic, prostate, and breast cancers, where increased or abnormally localized CLDN7 can promote migration, invasion, metastasis, and treatment resistance. Interpretation should therefore be cancer-type and localization specific.
Scientific Papers found: Click to Expand⟱
7696- IP6,  Ins,    The Combination of Inositol Hexaphosphate and Inositol Inhibits Metastasis of Colorectal Cancer Cells by Upregulating Claudin 7
- vitro+vivo, Colon, SW48 - in-vitro, Colon, SW-620
AntiCan↑, CLDN7↑, EMT↓, E-cadherin↑, N-cadherin↓, eff↑, TumCG↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

CLDN7↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,   TumCG↓, 1,  

Migration(tgid=13) ⓘ

E-cadherin↑, 1,   N-cadherin↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CLDN7, claudin 7
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1682  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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