Jun Cancer Research Results

Jun, Jun: Click to Expand ⟱
Source:
Type:
The JUN proto-oncogene is a gene that encodes a protein called c-Jun, which is a component of the AP-1 (Activator Protein 1) transcription factor complex.
Jun is a key component of the AP-1 (Activator Protein 1) transcription factor complex, which plays a significant role in regulating gene expression in response to various stimuli, including growth factors, stress, and cytokines. The Jun family includes several proteins, such as c-Jun, JunB, and JunD, which can have distinct roles in cancer biology.

In many cancers, Jun, particularly c-Jun, is activated and promotes cell proliferation, survival, and invasion. This activation is typically associated with poor prognosis and aggressive tumor behavior.
Scientific Papers found: Click to Expand⟱
232- AL,    A Single Meal Containing Raw, Crushed Garlic Influences Expression of Immunity- and Cancer-Related Genes in Whole Blood of Humans
- Human, Nor, NA
*AhR↑, x2.6 increase
*ARNT↑, x1.8 increase
*Hif1a↑, x1.6 increase (whole blood)
*Jun↑, x1.7 increase, x12@3-6hrs
*NFAT↑,
*NFAM1↑, 3 fold increase
*REL↑, x1.7 increase
*OSM↑, x1.8 increase
*NFAT↑, x1.4 increase NFATC3
*CXCc↑, x1.3 increase CXCL14
*IL2↑, x1.1
*IL6↑, x1.3
*LIF↑, x1.4

159- CUR,    Crosstalk from survival to necrotic death coexists in DU-145 cells by curcumin treatment
- in-vitro, Pca, DU145
ROS↑, at higher concentrations
p‑Jun↑, phosphorylation
p‑p38↑, Moreover, increased p38 phosphorylation was decreased soon after 4 h of curcumin treatment
TumAuto↑, curcumin-induced autophagy was related to caspase-dependent apoptotic cell death,
Casp8↑, Necrotic cell death by autophagy-induced caspase 8/9 degradation lasts until late stages of cell death after curcumin treatmen
Casp9↑,
Akt↓, decreased activities of Akt, ERK, and p38 after curcumin treatment (
ERK↓,
p38↓,


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Cell Death ⓘ

Akt↓, 1,   Casp8↑, 1,   Casp9↑, 1,   p38↓, 1,   p‑p38↑, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   p‑Jun↑, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Cell Death ⓘ

AhR↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

Jun↑, 1,  

Migration ⓘ

NFAM1↑, 1,   NFAT↑, 2,  

Angiogenesis & Vasculature ⓘ

Hif1a↑, 1,   REL↑, 1,  

Immune & Inflammatory Signaling ⓘ

CXCc↑, 1,   IL2↑, 1,   IL6↑, 1,   LIF↑, 1,   OSM↑, 1,  

Hormonal & Nuclear Receptors ⓘ

ARNT↑, 1,  

Clinical Biomarkers ⓘ

IL6↑, 1,  
Total Targets: 13

Scientific Paper Hit Count for: Jun, Jun
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:169  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

Home Page