ACADS/SCAD Cancer Research Results

ACADS/SCAD, Acyl-CoA Dehydrogenase, Short Chain: Click to Expand ⟱
Source:
Type:

ACADS - Acyl-CoA Dehydrogenase, Short Chain

Abbreviation: ACADS, SCAD

Type: Mitochondrial fatty-acid β-oxidation enzyme / acyl-CoA dehydrogenase

Function: ACADS encodes short-chain acyl-CoA dehydrogenase, a mitochondrial flavoprotein that catalyzes the first dehydrogenation step in β-oxidation of short-chain fatty acyl-CoAs, particularly butyryl-CoA. ACADS contributes to fatty-acid energy metabolism, mitochondrial function, and metabolic homeostasis.

Cancer: ↓ Reduced ACADS expression has been reported in cancers including colorectal cancer and hepatocellular carcinoma and is associated with tumor progression and poorer prognosis. Experimental restoration of ACADS can suppress proliferation, migration, and invasion. ACADS may also promote antitumor immunity by enhancing mitochondrial DNA leakage and cGAS-STING signaling, while ACADS deficiency can contribute to an immunosuppressive tumor microenvironment.
Scientific Papers found: Click to Expand⟱
7779- ISL,    Isoliquiritigenin-mediated miR-23a-3p inhibition activates PGC-1α to alleviate alcoholic liver injury
- in-vivo, Alcohol, NA
*hepatoP↑, *FAM↑, *PGC-1α↑, *PPARα↑, *CPT1A↑, *ACADS/SCAD↑, *ROS↓, *TNF-α↓, *IL1β↓, *IL6↓, *miR-23a-3p↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

ACADS/SCAD↑, 1,   FAM↑, 1,   miR-23a-3p↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

CPT1A↑, 1,   PPARα↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL1β↓, 1,   IL6↓, 1,   TNF-α↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

hepatoP↑, 1,  
Total Targets: 12

Scientific Paper Hit Count for: ACADS/SCAD, Acyl-CoA Dehydrogenase, Short Chain
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1695  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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