SYP Cancer Research Results

SYP, synaptophysin: Click to Expand ⟱
Source:
Type:

SYP - Synaptophysin

Abbreviation: SYP, Synaptophysin

Type: Presynaptic vesicle membrane protein / synaptic density biomarker / neuroendocrine marker

Function: Synaptophysin is an abundant integral membrane glycoprotein of presynaptic vesicles. It participates in synaptic vesicle organization, trafficking, exocytosis, and recycling and is widely used as a marker of presynaptic terminals and synaptic density. In pathology, SYP is also a standard marker of neuroendocrine differentiation.

Cancer: ↕ Context-dependent / lineage marker. Synaptophysin is frequently increased in neuroendocrine malignancies and is widely used diagnostically to identify neuroendocrine differentiation, including small-cell lung cancer, neuroendocrine prostate cancer, carcinoid tumors, and other neuroendocrine neoplasms. Increased SYP generally reflects neuroendocrine phenotype rather than a universal tumor-promoting mechanism.

Alzheimer's Disease: ↓ Reduced synaptophysin is a well-established marker of presynaptic and synaptic loss in Alzheimer's disease. Lower SYP levels are associated with synaptic degeneration and correlate with cognitive impairment and disease severity.
Scientific Papers found: Click to Expand⟱
7784- ISL,    Isoliquiritigenin attenuates lipopolysaccharide-induced cognitive impairment through antioxidant and anti-inflammatory activity
- in-vivo, AD, NA
*Learn↑, ISL pretreatment reversed these deficits as well as LPS-induced decreases in the hippocampal expression levels of synaptophysin, postsynaptic density-95, brain-derived neurotrophic factor, superoxide dismutase, glutathione peroxidase, and BCL-2.
*PSD95↑,
*BDNF↑,
*SOD↑,
*GPx↑,
*Bcl-2↑,
*SYP↑,
*Bax:Bcl2↓, ISL pretreatment also reversed LPS-induced increases in TUNEL-positive (apoptotic) cells, BAX/BCL-2 ratio, and expression levels of tumor necrosis factor-α, interleukin (IL)-1β, IL-6, and C-C motif chemokine ligand 3.
*TNF-α↓,
*IL1β↓,
*IL6↓,
*MIP‑1α/CCL3↓,
*p‑GSK‐3β↑, Pretreatment with ISL increased the expression levels of phosphorylated (p)-GSK-3β, nuclear NRF2, HO-1 mRNA, and NQO1 mRNA, and reversed LPS-induced nuclear translocation of nuclear factor (NF)-κB
*NRF2↑,
*HO-1↑,
*NQO1↑,
*cognitive↑, ISL protects against LPS-induced cognitive impairment and neuronal injury by promoting or maintaining antioxidant capacity and suppressing neuroinflammation, likely through phosphorylation-dependent inactivation of GSK-3β, enhanced expression of NRF
*Inflam↓,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

Learn↑, 1,   SYP↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

GPx↑, 1,   HO-1↑, 1,   NQO1↑, 1,   NRF2↑, 1,   SOD↑, 1,  

Cell Death(tgid=5) ⓘ

Bax:Bcl2↓, 1,   Bcl-2↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑GSK‐3β↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL1β↓, 1,   IL6↓, 1,   Inflam↓, 1,   MIP‑1α/CCL3↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 1,   PSD95↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 1,  
Total Targets: 19

Scientific Paper Hit Count for: SYP, synaptophysin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1698  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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