MEF2D Cancer Research Results

MEF2D, Myocyte Enhancer Factor 2D: Click to Expand ⟱
Source:
Type:

MEF2D - Myocyte Enhancer Factor 2D

Type: Transcription factor / MADS-box MEF2 family member

Function: MEF2D is a transcription factor that regulates cellular differentiation, proliferation, survival, apoptosis, stress responses, and neuronal function. Its transcriptional activity is controlled by intracellular signaling pathways including calcium-dependent signaling, MAPK pathways, GSK3β, HDACs, and transcriptional co-activators such as CBP/p300.

Cancer: ↕ Context-dependent. MEF2D can function as an oncogenic transcription factor in several cancers, promoting proliferation, migration, survival, and resistance to therapy. Increased MEF2D is associated with aggressive behavior in cancers including ovarian and colorectal carcinoma, while MEF2D rearrangements are oncogenic drivers in a subset of B-cell acute lymphoblastic leukemia. However, MEF2D can have different or tumor-suppressive functions depending on cellular and transcriptional context.
Scientific Papers found: Click to Expand⟱
7831- PCA,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*BBB↑, indicating its BBB permeability
*neuroP↑, neuroprotective activity of protocatechuic acid was observed by several animal models
*Aβ↓, Mechanism studies showed that protocatechuic acid inhibited Aβ plaque deposits via multiple ways, such as reduction of Aβ peptides production by inhibiting βsecretase activity, suppression of Aβ aggregation, and destabilization of performed Aβ f
*p‑tau↓, indicated that protocatechuic acid inhibited tau hyperphosphorylation and autophagy induced by okadaic acid through decreasing the activation of GSK-3β
*autophagy↓,
*GSK‐3β↓,
*NeuroI↓, antineuroinflammatory activity as indicated by the reduced neuroinflammatory markers, iNOS, and COX2 in the brain of AD mice.
*iNOS↓,
*COX2/PTGS2↓,
*BDNF↑, protocatechuic acid upregulated the expression of several cytoprotective factors, such as BDNF and myocyte enhancer factor 2D (MEF2D),
*MEF2D↑,
*cognitive↑, upregulated the cytoprotective factors, thus improving the cognitive and memory function of AD rodents.
*memory↑,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

autophagy↓, 1,   MEF2D↑, 1,   NeuroI↓, 1,  

Cell Death(tgid=5) ⓘ

iNOS↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

GSK‐3β↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 1,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 1,   memory↑, 1,   neuroP↑, 1,  
Total Targets: 13

Scientific Paper Hit Count for: MEF2D, Myocyte Enhancer Factor 2D
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1710  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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