FNDC5 Cancer Research Results

FNDC5, Fibronectin Type III Domain-Containing Protein 5: Click to Expand ⟱
Source:
Type:

FNDC5 - Fibronectin Type III Domain-Containing Protein 5

Abbreviation: FNDC5

Related Product: Irisin

Type: Transmembrane precursor protein / exercise-responsive myokine precursor

Function: FNDC5 is a membrane-associated protein expressed in skeletal muscle, brain, heart, and other tissues. Proteolytic cleavage of its extracellular domain generates irisin, a secreted signaling peptide associated with exercise-induced metabolic and neuroprotective effects. The PGC-1α/FNDC5/irisin pathway regulates energy metabolism, neuroplasticity, synaptic function, inflammatory signaling, and expression of neurotrophic factors including BDNF.

Cancer: ↕ Context-dependent. FNDC5/irisin signaling can influence tumor-cell metabolism, proliferation, apoptosis, invasion, and the tumor microenvironment, but reported effects vary considerably among cancer types and experimental models.

Alzheimer's Disease: ↓ Reduced or impaired FNDC5/irisin signaling is associated with Alzheimer's disease and cognitive dysfunction, whereas increased FNDC5/irisin signaling is generally neuroprotective. Experimental activation of this pathway improves synaptic plasticity and cognition and can reduce neuroinflammation, oxidative stress, amyloid-β pathology, and tau-related abnormalities.
Scientific Papers found: Click to Expand⟱
7901- IVT,    Isovitexin restores sevoflurane‑induced cognitive dysfunction by mediating autophagy through activation of the PGC‑1α/FNDC5 signaling pathway
- in-vivo, Nor, NA
*cognitive↑, *Apoptosis↓, *PGC-1α↑, *FNDC5↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

FNDC5↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PGC-1α↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 1,  
Total Targets: 4

Scientific Paper Hit Count for: FNDC5, Fibronectin Type III Domain-Containing Protein 5
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1716  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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