GDNF Cancer Research Results

GDNF, Glial Cell Line-Derived Neurotrophic Factor: Click to Expand ⟱
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GDNF - Glial Cell Line-Derived Neurotrophic Factor

Abbreviation: GDNF

Type: Neurotrophic growth factor / GDNF-family ligand

Function: GDNF is a secreted neurotrophic factor that promotes neuronal survival, differentiation, maintenance, and regeneration. It signals primarily by binding GFRα1 and activating the RET receptor tyrosine kinase, leading to downstream pathways including PI3K/AKT, RAS/MAPK/ERK, and related survival and growth signaling. GDNF is particularly important for dopaminergic, motor, sensory, and autonomic neurons.

Cancer: ↑ Frequently increased or functionally activated in selected cancers. GDNF/GFRα1/RET signaling can promote tumor-cell proliferation, survival, migration, invasion, perineural invasion, and metastatic behavior through pathways including PI3K/AKT, MAPK/ERK, JNK, NF-κB, integrins, and MMPs. The strength and direction of this effect vary by tumor type.

Alzheimer's Disease: Neuroprotective when ↑. GDNF supports neuronal survival and can reduce vulnerability to amyloid-β-associated toxicity, oxidative stress, and neurodegeneration in experimental models. Reduced GDNF has been reported in some Alzheimer's disease tissues and serum studies, although circulating and CSF findings are inconsistent.
Scientific Papers found: Click to Expand⟱
7902- VT,    Vitexin Protects Against Scopolamine-Induced Cognitive Impairment by Preserving Synaptic Integrity and Modulating Nrf2/HO-1 and NF-κB Signaling Pathways
- in-vivo, AD, NA
*Dose↝, Sco (2 mg/kg/day, i.p.), Sco + vitexin (30 mg/kg/day, oral), Sco + donepezil (1.5 mg/kg/day, i.p.), vitexin alone, and donepezil alone
*Learn↑, co significantly impaired spatial learning and memory while increasing anxiety-like behaviors. Vitexin treatment markedly improved these deficits, with efficacy comparable to donepezil
*memory↑,
*AChE↓, Sco elevated acetylcholinesterase activity, lipid peroxidation, and oxidative/nitrosative stress markers (TOS, OSI, MDA, Peroxynitrite, NO, and NOS) while decreasing total antioxidant status (TAS). Vitexin reversed these changes.
*lipid-P↓,
*TOS↓,
*MDA↓,
*ONOO↓,
*NO↓,
*NOS2↓,
*TAC↑,
*BDNF↑, Sco reduced hippocampal BDNF, GDNF, PSD95, and synaptophysin levels and increased GFAP, IL-6, TNF-α, NF-κB p65, and COX-2 expression. Vitexin restored neurotrophic and synaptic proteins, suppressed astrocyte activation and inflammatory signaling, a
*GDNF↑,
*PSD95↑,
*GFAP↓,
*NF-kB↓,
*COX2/PTGS2↓,
*NRF2↑, and activated the Nrf2/HO-1 pathway.
*HO-1↑,
*neuroP↑, vitexin exerts significant neuroprotective and synaptoprotective effects against Sco-induced cognitive impairment by simultaneously restoring redox balance
*NeuroI↓, suppressing neuroinflammation, and preserving synaptic integrity.


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

GDNF↑, 1,   GFAP↓, 1,   Learn↑, 1,   NeuroI↓, 1,   ONOO↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

HO-1↑, 1,   lipid-P↓, 1,   MDA↓, 1,   NRF2↑, 1,   TAC↑, 1,   TOS↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   NF-kB↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BDNF↑, 1,   PSD95↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

NOS2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

memory↑, 1,   neuroP↑, 1,  
Total Targets: 21

Scientific Paper Hit Count for: GDNF, Glial Cell Line-Derived Neurotrophic Factor
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1718  State#:%  Dir#:2
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