miR-107 Cancer Research Results

miR-107, MicroRNA-107: Click to Expand ⟱
Source:
Type:

miR-107 - MicroRNA-107

Abbreviation: miR-107

Type: MicroRNA / post-transcriptional gene-expression regulator

Function: miR-107 is a regulatory microRNA that suppresses target mRNAs through sequence-specific post-transcriptional repression. It influences cell-cycle control, metabolism, angiogenesis, migration, epithelial-mesenchymal transition, neuronal function, and amyloid precursor protein processing. One important neurological target is BACE1, the major β-secretase involved in amyloid-β production.

Cancer: ↕ Context-dependent. miR-107 functions as a tumor-suppressive microRNA in many experimental cancers, where increased miR-107 can inhibit proliferation, migration, invasion, angiogenesis, and epithelial-mesenchymal transition. However, oncogenic activity has also been reported in selected tumor types, so its effect depends on the dominant downstream targets and cellular context.

Alzheimer's Disease: ↓ Reduced miR-107 has been reported in Alzheimer's disease and may contribute to increased BACE1 expression and amyloidogenic APP processing. Increased miR-107 can suppress BACE1 and is therefore generally considered favorable for reducing amyloid-β production, although miR-107 also regulates additional neuronal and metabolic targets.
Scientific Papers found: Click to Expand⟱
7912- IVT,    Isovitexin modulates autophagy in Alzheimer’s disease via miR-107 signalling
- in-vivo, AD, NA
*memory↑, IVX administration ameliorated spatial memory loss and blunted a cascade of neuro-noxious episodes – including increased amyloid-beta (Aβ)
*Aβ↓,
*NeuroI↓, neuroinflammation
*PI3K↓, via the inhibition of PI3K/Akt/mTOR signalling axis.
*Akt↓,
*mTOR↓,
*miR-107↑, ascinatingly, we observed that miR-107 expression was significantly (P < 0.05) reinstated by the treatment with IVX against the downregulation of miR-107 expression in AD mice


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

miR-107↑, 1,   NeuroI↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTOR↓, 1,   PI3K↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Functional Outcomes(tgid=23) ⓘ

memory↑, 1,  
Total Targets: 7

Scientific Paper Hit Count for: miR-107, MicroRNA-107
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1720  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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