SLIT2 Cancer Research Results

SLIT2, Slit Guidance Ligand 2: Click to Expand ⟱
Source:
Type:

SLIT2 - Slit Guidance Ligand 2

Type: Secreted guidance protein / ROBO receptor ligand

Function: SLIT2 is a secreted extracellular guidance protein that signals primarily through ROBO-family receptors. It regulates cell migration, cytoskeletal organization, axon guidance, vascular development, immune-cell trafficking, epithelial integrity, and tissue morphogenesis. SLIT2/ROBO signaling can influence pathways involving small GTPases, β-catenin, PI3K/AKT, and migration-associated signaling.

Cancer: ↕ Context-dependent, with a frequently tumor-suppressive role. Reduced SLIT2 expression or promoter hypermethylation has been reported in several cancers. Restoration of SLIT2/ROBO signaling can inhibit epithelial-mesenchymal transition, migration, invasion, and metastasis. However, SLIT2 can also support angiogenesis or tumor progression in selected tumor and stromal contexts.
Scientific Papers found: Click to Expand⟱
7942- TQ,    Thymoquinone inhibits inflammation, neoangiogenesis and vascular remodeling in asthma mice
- in-vitro, Asthma, NA
*IL4↓, TQ inhibited the production of inflammatory factors interleukin-4/-5 (IL-4/-5) by enzyme-linked immunesorbent assay (ELISA).
*IL5↓,
*CD31/PECAM-1↓, platelet endothelial cell adhesion molecule-1, which is also known as CD31 and α-smooth muscle actinalpha (α-SMA) expression in asthma mice challenged by OVA was suppressed by TQ.
*VEGFR2/KDR/Flk1↓, TQ suppressed the activation of VEGFR2-PI3K-Akt pathway and up-regulated the expression of Slit glycoprotein-2 (Slit-2) both in vivo and in vitro
*PI3K↓,
*Akt↓,
*SLIT2↑,
*Inflam↓, Our study demonstrates that TQ attenuated the inflammatory reaction by antagonizing IL-4/-5 while the anti-neoangiogenesis effect of TQ is mediated by inhibition of vascular endothelial growth factor (VEGF)
*VEGF↓,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

SLIT2↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PI3K↓, 1,  

Migration(tgid=13) ⓘ

CD31/PECAM-1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,   VEGFR2/KDR/Flk1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL4↓, 1,   IL5↓, 1,   Inflam↓, 1,  
Total Targets: 9

Scientific Paper Hit Count for: SLIT2, Slit Guidance Ligand 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1743  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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