AntiP Cancer Research Results

AntiP, antiparasitic: Click to Expand ⟱
Source:
Type:

Antiparasitic Activity - Activity Against Parasitic Organisms

Type: Therapeutic effect / antimicrobial functional outcome

Function: Antiparasitic activity refers to the ability of a compound, extract, drug, or intervention to inhibit the growth, survival, replication, development, or infectivity of parasitic organisms. Depending on the study, this may include protozoa, helminths, or ectoparasites.

Favorable Direction: ↑ Antiparasitic activity = greater inhibition or killing of parasites and is generally favorable.

Unfavorable Direction: ↓ Antiparasitic activity = reduced effectiveness against parasites.
Scientific Papers found: Click to Expand⟱
8039- IVM,    Ivermectin-Induced Apoptotic Cell Death in Human SH-SY5Y Cells Involves the Activation of Oxidative Stress and Mitochondrial Pathway and Akt/mTOR-Pathway-Mediated Autophagy
- NA, neuroblastoma, SH-SY5Y
*toxicity↑, TumCD↑, ROS↑, mtDam↑, Apoptosis↑, MitoP↑, TumAuto↑, p‑Akt↓, p‑mTOR↓, LC3II↑, Beclin-1↑, ATG5↑, PINK1↑, PARK2↑, tumCV↓, MDA↑, SOD↑, Catalase↑, eff↓, MMP↓, BAX↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Cyt‑c↑, Bcl-2↓, proCasp3↓, Bax:Bcl2↑, eff↑, *AntiP↑, *Inflam↓, *AntiDiabetic↑, *AntiViral↑, BBB∅, toxicity↝,
8038- IVM,    Ivermectin and gemcitabine combination treatment induces apoptosis of pancreatic cancer cells via mitochondrial dysfunction
- in-vitro, PC, NA
*AntiP↑, AntiTum↑, ChemoSen↑, TumCP↓, TumCCA↑, cycD1/CCND1↓, mTOR↓, STAT3↑, Apoptosis↑, mtDam↑, ROS↑, MMP↓, OCR↓, MitoP↓,
8036- IVM,    Ivermectin inhibits the growth of ESCC by activating the ATF4-mediated endoplasmic reticulum stress-autophagy pathway
- in-vitro, ESCC, KYSE-30
*AntiP↑, AntiTum↑, ER Stress↑, TumAuto↑, ATF4↑, CHOP/DDIT3↝, TumCG↓, PERK↑, ROS↑, *toxicity↓, Ca+2↑,
8035- IVM,    Ivermectin and non-parasitic disorders: An update
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*AntiP↑, angioG↓, *AntiCan↓, mtDam↑, Apoptosis↑, necrosis↑, TumAuto↑, ROS↑, *neuroP↑, *Stroke↝, *cardioP↑,
8031- IVM,    Antiparasitic agents in oncology: Innovative mechanisms, emerging evidence and clinical potential in cancer treatment
*AntiP↑, Wnt↓, β-catenin/ZEB1↓, PI3K↓, Akt↓, mTOR↓, HH↓, Imm↑, CSCs↓, P-gp/ABCB1↓, Chl↓, angioG↓,
8029- IVM,    Ivermectin in Cancer Treatment: Should Healthcare Providers Caution or Explore Its Therapeutic Potential?
- Review, Var, NA
TumCP↓, Apoptosis↑, Wnt↓, β-catenin/ZEB1↓, Akt↓, mTOR↓, BBB∅, ROS↑, MMP↓, Casp3↓, Casp9↑, TumCCA↑, P53↑, cMyc↓, MMP9↓, HSP27↓, ICD↑, eff↑, *AntiP↑,
8027- IVM,    Progress in Understanding the Molecular Mechanisms Underlying the Antitumour Effects of Ivermectin
- Review, Var, NA
*AntiP↑, TumCD↑, PAK1↑, TumAuto↑, Casp↑, ICD↑, TCF↝, Hippo↓, Akt↓, mTOR↓, angioG↓, CSCs↓, MMP↓, Cyt‑c↑, Apoptosis↑, BAX↑, P53↑, Bcl-2↓, cycE/CCNE↓, cycD1/CCND1↓, CDK2↓, CDK6↓, CDK4↓, YAP/TEAD↓, TFE3↑, mTORC1↓, mitResp↓, OCR↓, compI↓, MMP↓, ROS↑, SOD2↑, ATP↓, eff↓, mitA↓, P-gp/ABCB1↓, TumVol↓,
8022- IVM,    Antibiotic ivermectin preferentially targets renal cancer through inducing mitochondrial dysfunction and oxidative damage
- vitro+vivo, RCC, NA
AntiP↑, TumCP↓, Apoptosis↑, selectivity↑, TumCG↓, MMP↓, mitResp↓, ATP↓, ROS↑, eff↓,
8021- IVM,    The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells
- vitro+vivo, AML, HL-60 - NA, lymphoma, U937 - NA, Pca, DU145
AntiP↑, TumCD↑, selectivity↑, TumCG↓, i-Chl↑, ROS↑, ChemoSen↑,
8020- IVM,    Ivermectin induces PAK1-mediated cytostatic autophagy in breast cancer
- vitro+vivo, BC, NA
AntiP↑, TumAuto↑, Akt↓, mTOR↓, PAK1↓, selectivity↑,
8049- IVM,    Ivermectin Induces Cytostatic Autophagy by Blocking the PAK1/Akt Axis in Breast Cancer
- vitro+vivo, BC, NA
*AntiP↑, AntiCan↑, AntiTum↑, PAK1↓, p‑Akt↓, Akt↓, mTOR↓, TumCG↓,
8044- IVM,    Current therapeutic applications and pharmacokinetic modulations of ivermectin
- Review, Var, NA
*AntiP↑, BioAv↓,

Showing Research Papers: 1 to 12 of 12

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 12

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

AntiP↑, 3,   TFE3↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 1,   compI↓, 1,   ICD↑, 2,   MDA↑, 1,   PARK2↑, 1,   ROS↑, 8,   SOD↑, 1,   SOD2↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 2,   mitResp↓, 2,   MMP↓, 6,   mtDam↑, 3,   OCR↓, 2,   PINK1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

cMyc↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 5,   p‑Akt↓, 2,   Apoptosis↑, 6,   BAX↑, 2,   Bax:Bcl2↑, 1,   Bcl-2↓, 2,   Casp↑, 1,   Casp3↓, 1,   cl‑Casp3↑, 1,   proCasp3↓, 1,   Casp9↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↑, 2,   Hippo↓, 1,   necrosis↑, 1,   TumCD↑, 3,   YAP/TEAD↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↝, 1,   ER Stress↑, 1,   HSP27↓, 1,   PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1↑, 1,   LC3II↑, 1,   MitoP↓, 1,   MitoP↑, 1,   TumAuto↑, 5,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 2,   cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   mitA↓, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 2,   HH↓, 1,   mTOR↓, 6,   p‑mTOR↓, 1,   mTORC1↓, 1,   PI3K↓, 1,   STAT3↑, 1,   TCF↝, 1,   TumCG↓, 4,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   Chl↓, 1,   i-Chl↑, 1,   MMP9↓, 1,   PAK1↓, 2,   PAK1↑, 1,   TumCP↓, 3,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   ATF4↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB∅, 2,   P-gp/ABCB1↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Imm↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   ChemoSen↑, 2,   eff↓, 3,   eff↑, 2,   selectivity↑, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiTum↑, 3,   toxicity↝, 1,   TumVol↓, 1,  
Total Targets: 86

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiP↑, 9,   Stroke↝, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiDiabetic↑, 1,   cardioP↑, 1,   neuroP↑, 1,   toxicity↓, 1,   toxicity↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,  
Total Targets: 10

Scientific Paper Hit Count for: AntiP, antiparasitic
12 Ivermectin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1749  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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