TFE3 Cancer Research Results

TFE3, Transcription Factor E3: Click to Expand ⟱
Source:
Type:

TFE3 - Transcription Factor E3

Type: MiT/TFE-family transcription factor / autophagy-lysosome regulator

Function: TFE3 is a transcription factor that regulates lysosomal biogenesis, autophagy, nutrient sensing, mitochondrial and metabolic adaptation, and cellular stress responses. Under nutrient-rich conditions, mTORC1-dependent phosphorylation promotes cytoplasmic retention of TFE3. During starvation or lysosomal stress, TFE3 translocates to the nucleus and activates CLEAR-network genes involved in lysosomal and autophagic function.

Cancer: ↑ Frequently activated or overexpressed in selected cancers and can promote tumor-cell survival, metabolic adaptation, autophagy, lysosomal function, invasion, migration, and treatment resistance. TFE3 gene fusions are oncogenic drivers in TFE3-rearranged renal cell carcinoma. However, MiT/TFE signaling can have context-dependent tumor-suppressive effects in some tissues.

Alzheimer's Disease: ↕ Context-dependent. TFE3 activation can promote autophagy and lysosomal biogenesis and enhance clearance of pathogenic proteins, which is potentially neuroprotective. However, increased TFE3/autophagy signaling can also occur as a compensatory response in Alzheimer's disease when downstream lysosomal clearance remains impaired, so TFE3 expression alone does not directly indicate effective autophagic flux.
Scientific Papers found: Click to Expand⟱
8027- IVM,    Progress in Understanding the Molecular Mechanisms Underlying the Antitumour Effects of Ivermectin
- Review, Var, NA
*AntiP↑, TumCD↑, PAK1↑, TumAuto↑, Casp↑, ICD↑, TCF↝, Hippo↓, Akt↓, mTOR↓, angioG↓, CSCs↓, MMP↓, Cyt‑c↑, Apoptosis↑, BAX↑, P53↑, Bcl-2↓, cycE/CCNE↓, cycD1/CCND1↓, CDK2↓, CDK6↓, CDK4↓, YAP/TEAD↓, TFE3↑, mTORC1↓, mitResp↓, OCR↓, compI↓, MMP↓, ROS↑, SOD2↑, ATP↓, eff↓, mitA↓, P-gp/ABCB1↓, TumVol↓,
8040- IVM,    Ivermectin, a potential anticancer drug derived from an antiparasitic drug
- Review, Var, NA
Akt↓, mTOR↓, TumAuto↑, TumCP↓, TumCCA↑, Wnt↓, YAP/TEAD↓, MMP↓, mitResp↓, ATP↓, eff↓, eff↑, ROS↑, ChemoSen↑, PAK1↓, MAPK↓, EMT↓, Beclin-1↑, ATG5↑, CSCs↓, STAT3↝, P-gp/ABCB1↓, MDR1↓, HSP27↓, Chl↑, TFE3↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

TFE3↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

compI↓, 1,   ICD↑, 1,   ROS↑, 2,   SOD2↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 2,   mitResp↓, 2,   MMP↓, 3,   OCR↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 2,   Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp↑, 1,   Cyt‑c↑, 1,   Hippo↓, 1,   MAPK↓, 1,   TumCD↑, 1,   YAP/TEAD↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP27↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1↑, 1,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   mitA↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 2,   EMT↓, 1,   mTOR↓, 2,   mTORC1↓, 1,   STAT3↝, 1,   TCF↝, 1,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

Chl↑, 1,   PAK1↓, 1,   PAK1↑, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,  

Barriers & Transport(tgid=15) ⓘ

P-gp/ABCB1↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   eff↓, 2,   eff↑, 1,   MDR1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

TumVol↓, 1,  
Total Targets: 49

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiP↑, 1,  
Total Targets: 1

Scientific Paper Hit Count for: TFE3, Transcription Factor E3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1750  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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