ChrCon Cancer Research Results

ChrCon, Chromatin Condensation: Click to Expand ⟱
Source:
Type:

Chromatin Condensation

Type: Cellular phenotype / nuclear morphology / apoptosis-associated outcome

Function: Chromatin condensation is the physical compaction of nuclear chromatin. It occurs physiologically during chromosome condensation in mitosis and can also occur during cellular stress and apoptosis. In apoptosis, chromatin typically condenses at the nuclear periphery and may subsequently undergo nuclear fragmentation.

Cancer: ↑ When induced by an anticancer treatment, chromatin condensation is commonly interpreted as evidence of apoptosis and therefore represents a favorable treatment-associated effect. However, chromatin condensation occurring during normal mitosis should not be interpreted as apoptosis.

Favorable Direction in Cancer Treatment: ↑ Apoptosis-associated chromatin condensation.
Scientific Papers found: Click to Expand⟱
8060- KAE,    Mechanisms underlying apoptosis-inducing effects of Kaempferol in HT-29 human colon cancer cells
- in-vitro, CRC, HT-29
TumCCA↑, DNAdam↑, ChrCon↑, cl‑Casp9↑, cl‑Casp3↑, cl‑Casp7↑, cl‑PARP↑, MPT↑, Cyt‑c↑, Bcl-xL↓, Bak↑, Akt↓, BAD↑, Casp↑, MMP↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ChrCon↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,   MPT↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   BAD↑, 1,   Bak↑, 1,   Bcl-xL↓, 1,   Casp↑, 1,   cl‑Casp3↑, 1,   cl‑Casp7↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  
Total Targets: 15

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ChrCon, Chromatin Condensation
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1753  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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