miR-339-5p Cancer Research Results

miR-339-5p, MicroRNA-339-5p: Click to Expand ⟱
Source:
Type:

miR-339-5p - MicroRNA-339-5p

Abbreviation: miR-339-5p

Type: MicroRNA / post-transcriptional gene-expression regulator

Function: miR-339-5p is a regulatory microRNA that binds complementary sequences within target mRNAs and suppresses their expression through mRNA degradation and/or translational inhibition. Reported targets include MDM2, BACE1, and other genes involved in proliferation, survival, invasion, and signaling.

Cancer: ↓ Frequently reduced in cancer and predominantly functions as a tumor-suppressive microRNA. miR-339-5p can directly inhibit MDM2, thereby enhancing p53 activity, apoptosis, senescence, and growth arrest. Increased miR-339-5p has also been shown to suppress cancer-cell proliferation, migration, invasion, and tumor growth.

Alzheimer's Disease: ↓ Reduced miR-339-5p has been reported in Alzheimer's disease brain tissue. miR-339-5p directly suppresses BACE1 expression; therefore, loss of miR-339-5p can contribute to increased BACE1 activity and increased amyloidogenic APP processing and Aβ production.

Favorable Direction: ↑ Restoration or increased miR-339-5p activity is generally favorable in both cancer and Alzheimer's disease contexts.
Scientific Papers found: Click to Expand⟱
8092- KAE,    Kaempferol Reverses Aerobic Glycolysis via miR-339-5p-Mediated PKM Alternative Splicing in Colon Cancer Cells
- in-vitro, Colon, HCT116 - in-vitro, Colon, DLD1
TumCP↓, TumCCA↑, Apoptosis↑, GlucoseCon↓, lactateProd↓, ATP↓, miR-339-5p↑, Glycolysis↓, PKM2↓, PKM1↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

miR-339-5p↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

GlucoseCon↓, 1,   Glycolysis↓, 1,   lactateProd↓, 1,   PKM1↑, 1,   PKM2↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: miR-339-5p, MicroRNA-339-5p
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1762  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

Home Page