miR-134 Cancer Research Results

miR-134, miR-134-5p: Click to Expand ⟱
Source:
Type:

miR-134-5p - MicroRNA-134-5p

Abbreviation: miR-134-5p, miR-134

Type: MicroRNA / post-transcriptional gene-expression regulator

Function: miR-134-5p is a brain-enriched regulatory microRNA that suppresses target mRNAs involved in synaptic plasticity, neuronal signaling, proliferation, survival, and oncogenic pathways. Important reported targets and downstream pathways include CREB1, BDNF-associated signaling, KRAS, STAT5B, EGFR, and MAPK/ERK signaling.

Cancer: ↓ Predominantly functions as a tumor-suppressive microRNA. Reduced miR-134-5p has been reported in multiple cancers, while restoration can inhibit proliferation, migration, invasion, metastasis, and oncogenic signaling. Reported targets include KRAS, STAT5B, EGFR, and other regulators of cell-cycle and survival pathways. Context-dependent effects have also been reported.

Alzheimer's Disease: ↑ Increased miR-134-5p has been observed in Aβ-associated Alzheimer's disease models and is linked to impaired synaptic plasticity. miR-134-5p suppresses CREB1 and BDNF-related plasticity pathways, while inhibition of miR-134-5p can restore long-term potentiation and synaptic tagging/capture in experimental Alzheimer's disease conditions.

Favorable Direction in Alzheimer's Disease: ↓ miR-134-5p activity is generally favorable because it can restore CREB1/BDNF signaling and improve synaptic plasticity.
Scientific Papers found: Click to Expand⟱
8151- lamb,    Suppression of STAT3 Phosphorylation and RelA/p65 Acetylation Mediated by MicroRNA134 Plays a Pivotal Role in the Apoptotic Effect of Lambertianic Acid
- in-vitro, BC, MCF7 - in-vitro, Pca, DU145 - in-vitro, Pca, PC3 - in-vitro, BC, MDA-MB-231
TumCCA↑, cl‑PARP↑, p‑STAT3↓, NF-kB↓, XIAP?, survivin↓, Bcl-2↓, Bcl-xL↓, VEGF↓, COX2/PTGS2↓, cMyc↓, IL6↓, TNF-α↓, ac‑p65↑, Obesity↓, miR-134↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

miR-134↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

XIAP?, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

cMyc↓, 1,  

Cell Death(tgid=5) ⓘ

Bcl-2↓, 1,   Bcl-xL↓, 1,   survivin↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑STAT3↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL6↓, 1,   NF-kB↓, 1,   ac‑p65↑, 1,   TNF-α↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Obesity↓, 1,  
Total Targets: 17

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: miR-134, miR-134-5p
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1766  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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