CASP4 Cancer Research Results

CASP4, Caspase-4: Click to Expand ⟱
Source:
Type:

CASP4 - Caspase 4

Abbreviation: CASP4, Caspase-4

Type: Inflammatory caspase / cysteine protease / noncanonical inflammasome mediator / pyroptosis regulator

Function: Caspase-4 is a human inflammatory caspase that directly senses cytosolic lipopolysaccharide (LPS) and activates the noncanonical inflammasome pathway. Activated caspase-4 cleaves gasdermin D (GSDMD), generating the pore-forming GSDMD N-terminal fragment and promoting pyroptotic cell death. Caspase-4-mediated potassium efflux can also activate the NLRP3-caspase-1 pathway and enhance inflammatory cytokine release.

Cancer: ↕ Context-dependent. ↑ Caspase-4 activity can promote pyroptotic death of cancer cells and enhance antitumor immune responses. However, chronic caspase-4-dependent inflammation and pyroptosis-associated cytokine release can also create a tumor-promoting inflammatory microenvironment in some cancers.

Favorable Direction in Cancer: Context-dependent. ↑ CASP4 activity can be favorable when it induces tumor-cell pyroptosis, whereas ↓ CASP4-associated inflammatory signaling may be favorable where chronic inflammation promotes tumor progression.

Interpretation Note: Caspase-4 is distinct from apoptotic executioner caspases such as CASP3 and CASP7. In humans, CASP4 and CASP5 mediate noncanonical inflammasome signaling; murine CASP11 is the functional counterpart.
Scientific Papers found: Click to Expand⟱
8261- LCA,    Licochalcone A induces T24 bladder cancer cell apoptosis by increasing intracellular calcium levels
- in-vitro, CRC, T24/HTB-9
TumCP↓, ROS↑, Apoptosis↑, ER Stress↑, i-Ca+2↑, MMP↓, APAF1↑, Casp9↑, Casp3↑, cal2↑, CASP4↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

CASP4↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,  

Cell Death(tgid=5) ⓘ

APAF1↑, 1,   Apoptosis↑, 1,   Casp3↑, 1,   Casp9↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,  

Migration(tgid=13) ⓘ

i-Ca+2↑, 1,   cal2↑, 1,   TumCP↓, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CASP4, Caspase-4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1792  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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