miR-21 Cancer Research Results
miR-21, miR-21: Click to Expand ⟱
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miR-21 is often considered an oncogenic microRNA because its overexpression is frequently observed in many cancers. It can promote tumor growth and progression by targeting and downregulating tumor suppressor genes.
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Scientific Papers found: Click to Expand⟱
MMP2↑, The 4 h LMF exposure caused a significant increase in MMP2 and MMP9, as well as in onco-miRs miR-155, miR-210, miR-21
MMP9↑,
miR-21↑,
miR-155↑, 57x
miR-210↑,
miR-200c↓, 1.25 fold decrease
miR-126↓, 2.5-fold decrease
FAK↓, Quercetin can inhibit HGF-induced melanoma cell migration by inhibiting the activation of c-Met and its downstream Gabl, FAK and PAK [84]
TumCCA↑, stimulation of cell cycle arrest at the G1 stage
p‑pRB↓, mediated through regulation of p21 CDK inhibitor and suppression of pRb phosphorylation resulting in E2F1 sequestering.
CDK2↑, low dose of quercetin has brought minor DNA injury and Chk2 induction
CycB/CCNB1↓, quercetin has a role in the reduction of cyclin B1 and CDK1 levels,
CDK1↓,
EMT↓, quercetin suppresses epithelial to mesenchymal transition (EMT) and cell proliferation through modulation of Sonic Hedgehog signaling pathway
PI3K↓, quercetin on other pathways such as PI3K, MAPK and WNT pathways have also been validated in cervical cancer
MAPK↓,
Wnt↓,
ROS↑, colorectal cancer, quercetin has been shown to suppress carcinogenesis through various mechanisms including affecting cell proliferation, production of reactive oxygen species and expression of miR-21
miR-21↑,
Akt↓, Figure 1 anti-cancer mechanisms
NF-kB↓,
FasL↑,
Bak↑,
BAX↑,
Bcl-2↓,
Casp3↓,
Casp9↑,
P53↑,
p38↑,
MAPK↑,
Cyt‑c↑,
PARP↓,
CHOP↑,
ROS↓,
LDH↑,
GRP78/BiP↑,
ERK↑,
MDA↓,
SOD↑,
GSH↑,
NRF2↑,
VEGF↓,
PDGF↓,
EGF↓,
FGF↓,
TNF-α↓,
TGF-β↓,
VEGFR2↓,
EGFR↓,
FGFR1↓,
mTOR↓,
cMyc↓,
MMPs↓,
LC3B-II↑,
Beclin-1↑,
IL1β↓,
CRP↓,
IL10↓,
COX2↓,
IL6↓,
TLR4↓,
Shh↓,
HER2/EBBR2↓,
NOTCH↓,
DR5↑, quercetin has enhanced DR5 expression in prostate cancer cells
HSP70/HSPA5↓, Quercetin has also suppressed the upsurge of hsp70 expression in prostate cancer cells following heat treatment and enhanced the quantity of subG1 cells
CSCs↓, Quercetin could also suppress cancer stem cell attributes and metastatic aptitude of isolated prostate cancer cells through modulating JNK signaling pathway
angioG↓, Quercetin inhibits angiogenesis-mediated of human prostate cancer cells through negatively modulating angiogenic factors (TGF-β, VEGF, PDGF, EGF, bFGF, Ang-1, Ang-2, MMP-2, and MMP-9)
MMP2↓,
MMP9↓,
IGFBP3↑, Quercetin via increasing the level of IGFBP-3 could induce apoptosis in PC-3 cells
uPA↓, Quercetin through decreasing uPA and uPAR expression and suppressing cell survival protein and Ras/Raf signaling molecules could decrease prostate cancer progression
uPAR↓,
RAS↓,
Raf↓,
TSP-1↑, Quercetin through TSP-1 enhancement could effectively inhibit angiogenesis
Showing Research Papers: 1 to 2 of 2
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress ⓘ
GSH↑, 1, MDA↓, 1, NRF2↑, 1, ROS↓, 1, ROS↑, 1, SOD↑, 1,
Mitochondria & Bioenergetics ⓘ
EGF↓, 1, FGFR1↓, 1, Raf↓, 1,
Core Metabolism/Glycolysis ⓘ
cMyc↓, 1, LDH↑, 1,
Cell Death ⓘ
Akt↓, 1, Bak↑, 1, BAX↑, 1, Bcl-2↓, 1, Casp3↓, 1, Casp9↑, 1, Cyt‑c↑, 1, DR5↑, 1, FasL↑, 1, MAPK↓, 1, MAPK↑, 1, p38↑, 1,
Kinase & Signal Transduction ⓘ
HER2/EBBR2↓, 1,
Transcription & Epigenetics ⓘ
miR-21↑, 2, p‑pRB↓, 1,
Protein Folding & ER Stress ⓘ
CHOP↑, 1, GRP78/BiP↑, 1, HSP70/HSPA5↓, 1,
Autophagy & Lysosomes ⓘ
Beclin-1↑, 1, LC3B-II↑, 1,
DNA Damage & Repair ⓘ
P53↑, 1, PARP↓, 1,
Cell Cycle & Senescence ⓘ
CDK1↓, 1, CDK2↑, 1, CycB/CCNB1↓, 1, TumCCA↑, 1,
Proliferation, Differentiation & Cell State ⓘ
CSCs↓, 1, EMT↓, 1, ERK↑, 1, FGF↓, 1, IGFBP3↑, 1, mTOR↓, 1, NOTCH↓, 1, PI3K↓, 1, RAS↓, 1, Shh↓, 1, Wnt↓, 1,
Migration ⓘ
FAK↓, 1, miR-155↑, 1, miR-200c↓, 1, MMP2↓, 1, MMP2↑, 1, MMP9↓, 1, MMP9↑, 1, MMPs↓, 1, PDGF↓, 1, TGF-β↓, 1, TSP-1↑, 1, uPA↓, 1, uPAR↓, 1,
Angiogenesis & Vasculature ⓘ
angioG↓, 1, EGFR↓, 1, miR-126↓, 1, miR-210↑, 1, VEGF↓, 1, VEGFR2↓, 1,
Immune & Inflammatory Signaling ⓘ
COX2↓, 1, CRP↓, 1, IL10↓, 1, IL1β↓, 1, IL6↓, 1, NF-kB↓, 1, TLR4↓, 1, TNF-α↓, 1,
Clinical Biomarkers ⓘ
CRP↓, 1, EGFR↓, 1, HER2/EBBR2↓, 1, IL6↓, 1, LDH↑, 1,
Total Targets: 80
Pathway results for Effect on Normal Cells:
Total Targets: 0
Scientific Paper Hit Count for: miR-21, miR-21
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:191 State#:% Dir#:2
wNotes=on sortOrder:rid,rpid
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