Nanog Cancer Research Results

Nanog, human hNanog protein coded by the NANOG gene: Click to Expand ⟱
Source:
Type:
NANOG is a transcription factor in embryonic stem cells (ESCs); Nanog is one of the key transcription factors, along with Oct4 and Sox2, involved in maintaining pluripotency in embryonic stem cells.’ Increased expression of Nanog has been associated with the aggressive nature of certain cancers, highlighting its role in promoting cancer stem cell characteristics.; Nanog's role in metastasis includes promoting the survival and proliferation of cancer stem cells in secondary sites, aiding their ability to establish new tumors.
Nanog is often expressed in cancer stem cells (CSCs).
High levels of Nanog expression have been correlated with increased tumor aggressiveness, metastasis, and the ability to evade apoptosis (programmed cell death).
Scientific Papers found: Click to Expand⟱
4630- OLE,    Targeting resistant breast cancer stem cells in a three-dimensional culture model with oleuropein encapsulated in methacrylated alginate microparticles
- in-vitro, BC, NA
Bcl-2↓, OLE-mALG induced apoptosis through the decrease in anti-apoptotic Bcl-2 and an increase in pro-apoptotic Bax, caspase-3, and caspase-9 protein levels.
BAX↑,
Casp3↑,
Casp9↑,
Vim↓, Vimentin and Slug protein levels decreased after 200 µg/mL OLE-mALG treatment to 3D breast cancer culture, E-cadherin levels increased.
Slug↓,
E-cadherin↑,
CSCs↓, OLE-mALG treatment to CSC co-culture led to a decrease in proliferation by triggering p21/SURVIVIN expressions, and also resulted in an increase in stemness genes (OCT3/4/NANOG/SOX2).
P21↑,
survivin↝,
OCT4↑, OCT3/4 — ~ 27-fold increase . simultaneously up-regulating stemness-associated transcription factors — a complex phenotype that the authors interpret not as promoting tumorigenicity
Nanog↑, NANOG — ~ 10-fold increase
SOX4↑, SOX2 — ~ 4-fold increase


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp9↑, 1,   survivin↝, 1,  

Cell Cycle & Senescence ⓘ

P21↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   Nanog↑, 1,   OCT4↑, 1,  

Migration ⓘ

E-cadherin↑, 1,   Slug↓, 1,   SOX4↑, 1,   Vim↓, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Nanog, human hNanog protein coded by the NANOG gene
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:212  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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