NOTCH2 Cancer Research Results

NOTCH2, Notch homolog 2 (Drosophila): Click to Expand ⟱

Source: CGL-Driver Genes

Type: TSG

NOTCH2 is a member of the Notch signaling pathway, which plays a crucial role in cell differentiation, proliferation, and apoptosis.
NOTCH2 can act as either a tumor suppressor or an oncogene.
Notch2 expression varies widely across cancer types. In some tumors, such as certain hematological malignancies and solid tumors like breast or lung cancer, Notch2 may be overexpressed or exhibit enhanced signaling activity.

– In contrast, other studies have observed reduced expression of Notch2 in tumors like hepatocellular carcinoma or pancreatic cancer, suggesting that its role can differ based on tissue context and tumor subtype.

Scientific Papers found: Click to Expand⟱

3097-

RES,

Resveratrol Induces Notch2-mediated Apoptosis and Suppression of Neuroendocrine Markers in Medullary Thyroid Cancer

in-vitro,

Thyroid,

25 μM, 50 μM, and 100 μM

TumCG↓, cl‑Casp3↑, p‑PARP↑, NOTCH2↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Cell Death ⓘ

cl‑Casp3↑, 1,

DNA Damage & Repair ⓘ

p‑PARP↑, 1,

Proliferation, Differentiation & Cell State ⓘ

NOTCH2↑, 1, TumCG↓, 1,
Total Targets: 4

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: NOTCH2, Notch homolog 2 (Drosophila)

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells