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| Tumor Microenvironment: Cancer cells often thrive in a more acidic environment compared to normal cells. This is partly due to the metabolic processes of cancer cells, which can produce lactic acid and other acidic byproducts. The acidic microenvironment can promote tumor growth and invasion. Many tumors exhibit an acidic microenvironment. This is largely due to the high rate of glycolysis (often referred to as the Warburg effect), even in the presence of oxygen, leading to lactate production. Acidification is thought to promote invasion, metastasis, and resistance to certain chemotherapies. The body maintains a relatively stable pH in the blood (around 7.4). However, the pH of tissues can vary, and tumors can exhibit a lower pH. -Normal tissues have a higher extracellular pH than intracellular pH, in cancer is exactly the opposite. (inversion of the pH gradient). Cancer cells often overexpress proton pumps (such as V-ATPase) and transporters that actively extrude protons (H⁺) to maintain an intracellular pH conducive to their growth. Inhibiting these pumps can lead to intracellular acidification and potentially induce apoptosis or render cancer cells more vulnerable to other treatments. Normal pH levels in the body: Nasal: ~6.3 pH Mouth/saliva: 6.2-7.6 pH Stomach: 1-3 pH Small Intestine: 5.9-6.8 pH Colon/Large Intestine: 6.8-7 pH |
| 1584- | Citrate, | Anticancer effects of high-dose extracellular citrate treatment in pancreatic cancer cells under different glucose concentrations |
| - | in-vitro, | PC, | MIA PaCa-2 | - | in-vitro, | PC, | PANC1 |
| 466- | CUR, | Curcumin circumvent lactate-induced chemoresistance in hepatic cancer cells through modulation of hydroxycarboxylic acid receptor-1 |
| - | in-vitro, | Liver, | HepG2 | - | in-vitro, | Liver, | HuT78 |
| 2308- | CUR, | Counteracting Action of Curcumin on High Glucose-Induced Chemoresistance in Hepatic Carcinoma Cells |
| - | in-vitro, | Liver, | HepG2 |
| 2249- | MF, | Pulsed electromagnetic fields modulate energy metabolism during wound healing process: an in vitro model study |
| - | in-vitro, | Nor, | L929 |
| 507- | MF, | Effects of extremely low frequency electromagnetic fields on the tumor cell inhibition and the possible mechanism |
| - | in-vitro, | Liver, | HepG2 | - | in-vitro, | Lung, | A549 | - | in-vitro, | Nor, | GP-293 |
| 5611- | NaHCO3, | NaHCO3 enhances the antitumor activities of cytokine-induced killer cells against hepatocellular carcinoma HepG2 cells |
| - | vitro+vivo, | HCC, | HepG2 |
| 5598- | NaHCO3, | Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases |
| - | in-vivo, | BC, | MDA-MB-231 |
| 5620- | NaHCO3, | Tumor acidity: From hallmark of cancer to target of treatment |
| - | Review, | Var, | NA |
| 5617- | NaHCO3, | Microenvironmental alkalization promotes the therapeutic effects of MSLN-CAR-T cells |
| - | vitro+vivo, | NA, | NA |
| 5616- | NaHCO3, | DCA, | Bicarbonate and dichloroacetate: Evaluating pH altering therapies in a mouse model for metastatic breast cancer |
| - | vitro+vivo, | BC, | MDA-MB-231 |
| 5615- | NaHCO3, | immuno, | pH-Responsive Nanoparticles for Cancer Immunotherapy: A Brief Review |
| - | Review, | Var, | NA |
| 5614- | NaHCO3, | Targeting the Acidic Tumor Microenvironment: Unexpected Pro-Neoplastic Effects of Oral NaHCO3 Therapy in Murine Breast Tissue |
| - | in-vivo, | BC, | NA |
| 5613- | NaHCO3, | The Potential Role of Systemic Buffers in Reducing Intratumoral Extracellular pH and Acid-Mediated Invasion |
| - | Study, | Var, | NA |
| 5612- | NaHCO3, | immuno, | Neutralization of tumor acidity improves anti-tumor responses to immunotherapies |
| - | vitro+vivo, | Var, | B16-F10 |
| 5599- | NaHCO3, | Acidity generated by the tumor microenvironment drives local invasion |
| - | in-vivo, | BC, | MDA-MB-231 | - | in-vitro, | CRC, | HCT116 |
| 5610- | NaHCO3, | doxoR, | Sodium bicarbonate nanoparticles modulate the tumor pH and enhance the cellular uptake of doxorubicin |
| - | vitro+vivo, | BC, | 4T1 |
| 5609- | NaHCO3, | Alkalization of cellular pH leads to cancer cell death by disrupting autophagy and mitochondrial function |
| - | in-vitro, | Var, | NA |
| 5608- | NaHCO3, | Sodium Bicarbonate Nanoparticles for Amplified Cancer Immunotherapy by Inducing Pyroptosis and Regulating Lactic Acid Metabolism |
| - | Study, | Var, | NA |
| 5607- | NaHCO3, | Does Baking Soda Function as a Magic Bullet for Patients With Cancer? A Mini Review |
| - | Review, | Var, | NA |
| 5604- | NaHCO3, | Mitochondrial metabolic reprogramming of macrophages and T cells enhances CD47 antibody-engineered oncolytic virus antitumor immunity |
| - | vitro+vivo, | Melanoma, | B16-BL6 | - | in-vitro, | BC, | 4T1 |
| 5603- | NaHCO3, | immuno, | Acidosis-mediated increase in IFN-γ-induced PD-L1 expression on cancer cells as an immune escape mechanism in solid tumors |
| - | in-vitro, | BC, | MCF-7 | - | in-vitro, | PC, | MIA PaCa-2 | - | in-vitro, | GBM, | U87MG |
| 5602- | NaHCO3, | immuno, | Immunotherapy Enhancement by Targeting Extracellular Tumor pH in Triple-Negative Breast Cancer Mouse Model |
| - | in-vivo, | BC, | 4T1 |
| 5601- | NaHCO3, | Tumor acidity, ion trapping and chemotherapeutics. II. pH-dependent partition coefficients predict importance of ion trapping on pharmacokinetics of weakly basic chemotherapeutic agents |
| - | vitro+vivo, | Var, | NA |
| 5600- | NaHCO3, | Acidosis and Cancer: from Mechanism to Neutralization |
| - | Review, | Var, | NA |
| 1671- | PBG, | Importance of pH Homeostasis in Metabolic Health and Diseases: Crucial Role of Membrane Proton Transport |
| - | Review, | Nor, | NA |
| 1658- | PBG, | Body Fluid pH Balance in Metabolic Health and Possible Benefits of Dietary Alkaline Foods |
| - | Review, | Var, | NA |
| 1659- | PBG, | Improvement of insulin resistance, blood pressure and interstitial pH in early developmental stage of insulin resistance in OLETF rats by intake of propolis extracts |
| - | in-vivo, | Nor, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
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