Bcl-2 Cancer Research Results

Bcl-2, B-cell CLL/lymphoma 2: Click to Expand ⟱
Source: HalifaxProj (inhibit) CGL-Driver Genes
Type: Antiapoptotic Oncogene
The proteins of BCL-2 family are classified into three subgroups, i.e., the anti-apoptotic/pro-survival proteins represented by BCL-2 and BCL-XL, the pro-apoptotic proteins represented by BAX and Bak, and the pro-apoptotic BH3-only proteins represented by BAD and BID.
Since the expression of Bcl-2 protein in tumor cells is much higher than that in normal cells, inhibitors targeting it have little effect on normal cells.
Scientific Papers found: Click to Expand⟱
4438- AgNPs,  ART/DHA,    Biogenic synthesis of AgNPs using Artemisia oliveriana extract and their biological activities for an effective treatment of lung cancer
- in-vitro, Lung, A549
EPR↑, BAX↑, Bcl-2↑, Casp3↑, Casp9↑, DNAdam↑, TumCCA↑, Apoptosis↑,
246- AL,    Allicin induces apoptosis of the MGC-803 human gastric carcinoma cell line through the p38 mitogen-activated protein kinase/caspase-3 signaling pathway
- in-vitro, GC, MGC803
Apoptosis↑, cl‑Casp3↑, p38↑, tumCV↓, BAX↑, Bcl-2↑,
3162- Ash,    Molecular insights into cancer therapeutic effects of the dietary medicinal phytochemical withaferin A
- Review, Var, NA
lipid-P↓, SOD↑, GPx↑, P53↑, Bcl-2↑, E6↓, E7↓, pRB↑, CycB/CCNB1↑, CDC2↑, P21↑, PCNA↓, ALDH1A1↓, Vim↓, Glycolysis↓, cMyc↓, BAX↑, NF-kB↓, Casp3↑, CHOP/DDIT3↑, DR5↑, ERK↓, Wnt↓, β-catenin/ZEB1↓, Akt↓, HSP90↓,
2629- Ba,    Baicalein, a Component of Scutellaria baicalensis, Attenuates Kidney Injury Induced by Myocardial Ischemia and Reperfusion
- in-vivo, Nor, NA
*RenoP↑, *Apoptosis↓, *TNF-α↓, *IL1↓, *Bcl-2↑, *BAX↓, *Akt↑,
5633- BCA,    Mechanisms Behind the Pharmacological Application of Biochanin-A: A review
- Review, Var, NA - Review, AD, NA
*AntiDiabetic↑, *neuroP↑, *toxicity↓, *CYP19↓, p‑Akt↓, mTOR↓, TumCCA↑, P21↑, Casp3↑, Bcl-2↑, Apoptosis↑, E-cadherin↓, TumMeta↓, eff↑, GSK‐3β↓, β-catenin/ZEB1↓, RadioS↑, ROS↑, Casp1↑, MMP2↓, MMP9↓, EGFR↓, ChemoSen↑, PI3K↓, MMPs↓, Hif1a↓, VEGF↓, *ROS↓, *Obesity↓, *cardioP↑, *NRF2↑, *NF-kB↓, *Inflam↓, *lipid-P↓, *hepatoP↑, *AST↓, *ALP↓, *Bacteria↓, *neuroP↑, *SOD↑, *GPx↑, *AChE↓, *BACE/β-secretase↓, *memory↑, *BioAv↓,
5636- BCA,    Biochanin A Induces S Phase Arrest and Apoptosis in Lung Cancer Cells
- vitro+vivo, Lung, A549
tumCV↓, TumCCA↑, Apoptosis↑, MMP↓, TumCG↓, P21↑, Casp3↑, Bcl-2↑,
2733- BetA,    Betulinic Acid Inhibits Cell Proliferation in Human Oral Squamous Cell Carcinoma via Modulating ROS-Regulated p53 Signaling
- in-vitro, Oral, KB - in-vivo, NA, NA
TumCP↓, TumVol↓, mt-Apoptosis↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↑, OCR↓, TumCCA↑, ROS↑, eff↓, P53↑, STAT3↓, cycD1/CCND1↑,
1448- Bos,    A triterpenediol from Boswellia serrata induces apoptosis through both the intrinsic and extrinsic apoptotic pathways in human leukemia HL-60 cells
- in-vitro, AML, HL-60
TumCP↓, Apoptosis↑, ROS↑, NO↑, cl‑Bcl-2↑, BAX↑, MMP↓, Cyt‑c↑, AIF↑, Diablo↑, survivin↓, ICAD↓, Casp↑, cl‑PARP↑, DR4↑, TNFR 1↑,
6542- BSB,    Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol
- Review, Var, NA - Review, Park, NA - Review, AD, NA
AntiCan↑, *neuroP↑, *cardioP↑, *AntiBio↑, *BioAv↑, *toxicity↓, *BioAv↑, *motorD↑, *SOD↑, *Catalase↑, *Keap1↑, *MDA↓, *GSH↑, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *lipid-P↓, *Cyt‑c↓, *ROS↓, *MMP↑, *antiOx↑, *AChE↓, *Apoptosis↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BACE/β-secretase↓, *BChE↓, *eff↑, *Aβ↓, *ATP↑, RadioS↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Apoptosis↑, PARP↑, BAX↑, BID↑, NF-kB↑, Fas↑, EGFR↑, TIMP2↑, XIAP↓, COX2/PTGS2↓, Bak↓, Bcl-2↓, P53↑, HER2/EBBR2↓, FGF↓, CEA↓, Akt↓, TumCCA↑, *Imm↑, *CD4+↑, *CD8+↑, *BBB↑, *Pain↓, *cardioP↑, *TBARS↓, *SOD↑, *Catalase↑, *GSH↑, *AntiBio↑, *AntiFungal↑, *GastroP↑, *RenoP↑, *creat↓, *uricA↓, *Inflam↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↑, *MMP13↓,
6553- BSB,    Pharmacological and biological effects of alpha-bisabolol: An updated review of the molecular mechanisms
- Review, Nor, NA
*ROS↓, *Inflam↓, *Inf↓, *neuroP↑, *RNS↓, *MDA↓, *GSH↑, *MPO↓, *SOD↑, *Catalase↑, *Bcl-2↑, *BAX↓, *P53↓, *APAF1↓, *Casp3↓, *Casp9↓, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *ERK↓, *JNK↓, *NF-kB↓, *p38↓, *cognitive↑, *BChE↓,
5201- CAP,    Inhibiting ROS-STAT3-dependent autophagy enhanced capsaicin-induced apoptosis in human hepatocellular carcinoma cells
- NA, HCC, HepG2
AntiCan↓, Apoptosis↑, cl‑PARP↑, Bcl-2↑, TumAuto↑, LC3II↑, eff↑, STAT3↑, ROS↑, eff↓,
6650- Cen,    Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review
- Review, AD, NA
*BioAv↝, *BioAv↝, *MDA↓, *GSH↑, *SOD↑, *AChE↓, *memory↑, *Ki-67↑, *Catalase↑, *PI3K↑, *BDNF↑, *NGF↑, *ROS↓, *NRF2↑, *HO-1↑, *NQO1↑, *ATP↑, *OCR↑, *TNF-α↓, *PP2A↑, *GSK‐3β↓, *Bcl-2↑, *TrkB↑, *NOTCH1↑, *SOX2↑, *Nestin↑, *MDA↓, *MAOA↓, *MAOB↓, *GPx↑, *cognitive↑, *ROS↓, *neuroP↑, *glucose↓, *ALAT↓, *AST↓, *PFK↓, *Weight↓, *Inflam↓, *AntiDiabetic↑, *Obesity↓, *Wound Healing↑, *cardioP↑, *GutMicro↑, *Sepsis↓, *BioAv↑,
6068- CHL,    Dietary chlorophyllin inhibits the canonical NF-κB signaling pathway and induces intrinsic apoptosis in a hamster model of oral oncogenesis
- in-vivo, Oral, NA
NF-kB↓, IKKα↓, Apoptosis↓, Bcl-2↑, survivin↓, Casp↑, cl‑PARP↑,
2807- CHr,    Evidence-based mechanistic role of chrysin towards protection of cardiac hypertrophy and fibrosis in rats
- in-vivo, Nor, NA
*antiOx↑, Inflam↓, *cardioP↑, *GSH↑, *SOD↑, *Catalase↑, *GAPDH↑, *BAX↓, *Bcl-2↑, *PARP↓, *Cyt‑c↓, *Casp3↓, *NOX4↓, *NRF2↑, *HO-1↑, *HSP70/HSPA5↑,
6623- Cic,  MTX,    Chicoric acid prevents methotrexate hepatotoxicity via attenuation of oxidative stress and inflammation and up-regulation of PPARγ and Nrf2/HO-1 signaling
- in-vivo, Nor, NA
*antiOx↑, *hepatoP↑, *ROS↓, *lipid-P↓, *TAC↑, *NRF2↑, *HO-1↑, *NQO1↑, *PPARγ↑, *Inflam↓, *Apoptosis↓, *Bcl-2↑, *BAX↓, *Cyt‑c↓, *Casp3↓,
6141- Cin,    The role and mechanism of cinnamaldehyde in cancer
- Review, Var, NA
Apoptosis↑, Casp↑, mtDam↑, angioG↓, TumCP↓, *Inflam↓, *antiOx↑, *ROS↓, *DNAdam↓, ROS↑, *Bcl-2↑, *BAX↓, *NF-kB↓, ChemoSen↑, ICAM-1↓, VCAM-1↓, PI3K↓, Akt↓, mTOR↓, BioAv↝,
3630- Cro,    Crocin Improves Cognitive Behavior in Rats with Alzheimer's Disease by Regulating Endoplasmic Reticulum Stress and Apoptosis
- in-vivo, AD, NA
*memory↑, *Bcl-2↑, *BAX↓, *Casp3↓, *GRP78/BiP↓, *CHOP/DDIT3↓, *Dose↝,
6531- CRV,    D-carvone attenuates LPS-induced acute lung injury via TLR4/NF-κB and Nrf2/HO-1 signaling pathways in rats
- in-vivo, Nor, NA
*TRAF1↓, *IL1β↓, *TNF-α↓, *ROS↓, *MDA↓, *GSH↑, *SOD↑, *Inflam↓, *NRF2↑, *Bcl-2↑, *IL8↓, *antiOx↑,
7423- CS,    Prophylactic effects of Cynara scolymus L. leaf and flower hydroethanolic extracts against diethylnitrosamine/acetylaminoflourene-induced lung cancer in Wistar rats
- in-vivo, Nor, NA
*lipid-P↓, *GSTs↑, *GPx↑, *GSR↑, *SOD↑, *P53↑, *Bcl-2↑, *ROS↓,
3576- CUR,    Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer's Disease
- Review, AD, NA
*Inflam↓, *antiOx↑, *memory↑, *Aβ↓, *BBB↑, *cognitive↑, *tau↓, *LDL↓, *AChE↓, *IL1β↓, *IronCh↑, *neuroP↑, *BioAv↝, *PI3K↑, *Akt↑, *NRF2↑, *HO-1↑, *Ferritin↑, *HO-2↓, *ROS↓, *Ach↑, *GSH↑, *Bcl-2↑, *ChAT↑,
6780- EGCG,    The pharmacological activity of epigallocatechin-3-gallate (EGCG) on Alzheimer's disease animal model: A systematic review
- Review, AD, NA
*neuroP↑, *tau↓, *antiOx↑, *Inflam↓, *Apoptosis↓, *AChE↓, *TNF-α↓, *JNK↓, *NGF↑, *SOD↑, *GPx↑, *MDA↓, *NO↓, *ROS↓, *iNOS↓, *COX2/PTGS2↓, *BAX↓, *CHOP/DDIT3↓, *GRP78/BiP↓, *Bcl-2↑, *Dose↑, *BioAv↑, *hepatoP↓,
6828- EMD,    Neuroprotective effect of emodin against Alzheimer's disease via Nrf2 signaling in U251 cells and APP/PS1 mice
- in-vitro, AD, U251
*MMP↑, *ROS↓, *NRF2↑, *HO-1↑, *SOD↑, *Bcl-2↑, *Catalase↑, *BAX↓, *memory↑, *ANXi↓, *Aβ↓, *antiOx↑, *MDA↓,
6829- EMD,    Molecular Mechanisms of Action of Emodin: As an Anti-Cardiovascular Disease Drug
*diuretic↑, *Bacteria↓, *AntiViral↑, *Inflam↓, AntiCan↑, *cardioP↑, *NF-kB↓, *TNF-α↓, *IL1β↓, *NO↑, *eNOS↑, *PPARγ↑, *Casp9↓, *Casp3↓, *GSDMD↓, *Bcl-2↑, *STAT3↑, *ATP↑, *SOD↑, *GSH↑, *HDAC2↓, *SIRT3↑, ROS↑, PCNA↓, P53↑, cMyc↓,
6977- Form,    Differential ability of formononetin to stimulate proliferation of endothelial cells and breast cancer cells via a feedback loop involving MicroRNA-375, RASD1, and ERα
- in-vitro, BC, MCF7 - in-vitro, BC, BT474 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, HUVECs
*Apoptosis↓, miR-375↝, p‑Akt↑, Bcl-2↑,
3723- GBE,    Can We Use Ginkgo biloba Extract to Treat Alzheimer’s Disease? Lessons from Preclinical and Clinical Studies
- Review, AD, NA
*memory↑, *antiOx↑, *Casp3↓, *APP↓, *AChE↓, *Aβ↓, *5HT↑, *SOD↓, *MDA↓, *NO↓, *GSH↑, *Bcl-2↑, *BAX↑, *TNF-α↓, *IL1β↑, *iNOS↓, *IL10↓, *p‑tau↓, *ROS↓, *MAOB↓, *cognitive↑, *neuroP↑, *Apoptosis↓,
7275- GGB,    Protective Effect of Ginkgolide B against Cognitive Impairment in Mice via Regulation of Gut Microbiota
- in-vivo, AD, NA
*cognitive↑, *neuroP↑, *RAGE↓, *BAX↓, *Bcl-2↑, *GutMicro↑,
7277- GGB,    Ginkgolide B inhibits hydrogen peroxide-induced apoptosis and attenuates cytotoxicity via activating the PI3K/Akt/mTOR signaling pathway in H9c2 cells
- in-vitro, Nor, H9c2
*cardioP↑, *Bcl-2↑, *cl‑Casp3↓, *BAX↓, *PI3K↑, *Akt↑, *mTOR↑,
7279- GGB,  Rad,    Radioprotective effect of Ginkgolide B on brain: the mediating role of DCC/MST1 signaling
- in-vivo, Nor, NA
*cognitive↑, *radioP↑, *ROS↓, *p‑Akt↑, *Bcl-2↑, *Mst1↓, *p‑p38↓, *JNK↓, *cl‑Casp3↓, *BAX↓,
7138- GI,    6-Shogaol exerts anti-proliferative and pro-apoptotic effects through the modulation of STAT3 and MAPKs signaling pathways
- vitro+vivo, BC, MDA-MB-231 - in-vitro, Pca, DU145 - in-vitro, Liver, HepG2 - in-vitro, Lung, A549
TumCP↓, TumMeta↓, p‑STAT3↓, JAK2↓, cSrc↓, JNK↑, p38↑, ERK↑, eff↓, ROS↑, cl‑PARP↑, TumCCA↑, Casp8↑, Casp9↑, Casp3↑, eff↑, Bcl-2↑, Bcl-xL↓, survivin↓, MMP9↓, COX2/PTGS2↓, IAP1↓, Dose?,
7256- Gink,    Neuroprotective effect of ginkgetin in experimental cerebral ischemia/reperfusion via apoptosis inhibition and PI3K/Akt/mTOR signaling pathway activation
- in-vivo, Stroke, NA
*Stroke↓, *Apoptosis↓, *Casp3↓, *BAX↓, *Bcl-2↑, *p‑Akt↑, *p‑mTOR↑,
7330- GSE,    Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention
- Review, Var, NA
*BioAv↑, *ROS↓, AntiCan↑, selectivity↑, RenoP↑, *hepatoP↑, *DNAdam↓, *Stroke↓, *Bcl-2↑, cMyc↓,
7489- H2,    Molecular Hydrogen in the Treatment of Respiratory Diseases
- Review, Asthma, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *Dose↓, *Dose↝, *eff↑, *ROS↓, *RNS↓, *NRF2↑, *HO-1↑, *Fenton↓, *NLRP3↓, *NADPH↓, *NOX4↓, *NOX↓, *MPO↓, *NF-kB↓, *TNF-α↓, *IL6↓, *IL1β↓, *HMGB1↓, *IL4↑, *IL10↑, *M2 MC↑, *Treg lymp↝, *Bcl-2↑, *Bcl-xL↑, *PI3K↑, *Akt↑, *JAK2↑, *STAT3↑, *Dose↑, *CD4+↑, *CD25+↑, *FOXP3↑, *MDA↓, *SOD↑, *Catalase↑, *Casp3↓, *Casp9↓, *TBARS↓, *SpO2↑, *VitE↓, *OS↑, *Weight↑, *DNAdam↓, *PGE2↓, *MCP1/CCL2↓, *lipid-P↓, *TumCP↓, *tumCV↓, *TumCMig↓, *TumCI↓, TumW↓, TumVol↓, selectivity↑, QoL↑, ChemoSen↑, chemoP↑, radioP↑, ROS↑, NLRP3↑, Casp3↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓,
3764- H2,    Therapeutic Effects of Hydrogen Gas Inhalation on Trimethyltin-Induced Neurotoxicity and Cognitive Impairment in the C57BL/6 Mice Model
- in-vivo, AD, NA
*memory↑, *Aβ↓, *p‑tau↓, *BAX↓, *ROS↓, *NO↓, *Ca+2↓, *MDA↓, *Catalase↓, *GPx↓, *TNF-α↓, *Bcl-2↑, *VEGF↑, *Inflam↓, *cognitive↑,
7499- H2S,    Hydrogen sulfide slows down progression of experimental Alzheimer's disease by targeting multiple pathophysiological mechanisms
*TNF-α↓, *Bcl-2↑, *BAX↓, *Casp3↓, *Inflam↓, *Apoptosis↓, *memory↑,
2867- HNK,    Honokiol ameliorates oxidative stress-induced DNA damage and apoptosis of c2c12 myoblasts by ROS generation and mitochondrial pathway
- in-vitro, Nor, C2C12
*antiOx↑, *ROS↓, *Bcl-2↑, *BAX↓, Casp9∅, Casp3∅, cl‑PARP∅, Cyt‑c?,
4212- Hup,    Huperzine A Alleviates Oxidative Glutamate Toxicity in Hippocampal HT22 Cells via Activating BDNF/TrkB-Dependent PI3K/Akt/mTOR Signaling Pathway
- in-vitro, Nor, HT22
*ROS↓, *p‑Akt↓, *p‑mTOR↓, *p‑p70S6↓, *BDNF↑, *Apoptosis↓, *Casp3↓, *Bcl-2↑,
7561- HYP,    Hyperoside Exerts Therapeutic Effects on Parkinson's Disease by Mitigating Oxidative Stress through Activation of Nrf2/HO-1 Pathway
- in-vivo, Park, NA
*motorD↑, *NRF2↑, *HO-1↑, *Bcl-2↑, *BAX↓, *GSH↑, *GPx↑, *SOD↑, *Catalase↑, *MDA↓, *Apoptosis↓,
7560- HYP,    Hyperoside: A Review of Its Structure, Synthesis, Pharmacology, Pharmacokinetics and Toxicity
- Review, Nor, NA - Review, AD, NA
*RenoP↓, Casp3↑, Casp8↑, MDA↑, GSH↓, SOD↓, Catalase↓, VEGF↓, Bcl-2↓, TumCG↓, p‑Akt↓, PI3K↓, TumCCA↑, TumCP↓, BMP7/OP1↓, *ZO-1↑, *BBB↝, *p‑Akt↑, *GSK‐3β↑, *SOD↑, *Catalase↑, *GSH↑, *SIRT1↑, *NF-kB↓, *IL1β↓, *IL6↓, *IL8↓, *TNF-α↓, *ROS↓, *MDA↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BDNF↑, *TrkB↑, *NGF↑, *Apoptosis↓, *cardioP↑, *AST↓, *hepatoP↑, *AST↓, *ALAT↓, *MDA↓, *BACH1↓, *neuroP↑, *Stroke↓, *ICAM-1↓, *VCAM-1↓, *TLR4↓, *COX2/PTGS2↓, *RenoP↑, *NLRP3↓, *Casp1↓, *ASC↓, *BioAv↓, *BioAv↑, *toxicity↓,
7784- ISL,    Isoliquiritigenin attenuates lipopolysaccharide-induced cognitive impairment through antioxidant and anti-inflammatory activity
- in-vivo, AD, NA
*Learn↑, *PSD95↑, *BDNF↑, *SOD↑, *GPx↑, *Bcl-2↑, *SYP↑, *Bax:Bcl2↓, *TNF-α↓, *IL1β↓, *IL6↓, *MIP‑1α/CCL3↓, *p‑GSK‐3β↑, *NRF2↑, *HO-1↑, *NQO1↑, *cognitive↑, *Inflam↓,
7864- isoO,    Isoorientin Inhibits Amyloid β25-35-Induced Neuronal Inflammation in BV2 Cells by Blocking the NF-κB Signaling Pathway
- in-vitro, AD, BV2
*iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↓, *ROS↓, *NF-kB↓, *Apoptosis↓, *Bcl-2↑, *BAX↓, *cl‑Casp9↓, *cl‑Casp3↓, *cl‑PARP↓, *NeuroI↓,
7870- isoO,    Anti-oxidative stress and cognitive improvement of a semi-synthetic isoorientin-based GSK-3β inhibitor in rat pheochromocytoma cell PC12 and scopolamine-induced AD model mice via AKT/GSK-3β/Nrf2 pathway
- vitro+vivo, AD, PC12
*GSK‐3β↓, *BAX↓, *Casp3↓, *cl‑Casp3↓, *Bcl-2↑, *MDA↓, *ROS↓, *SOD↑, *GPx↑, *p‑Akt↑, *p‑GSK‐3β↑, *NRF2↑, *p‑CREB↑, *BDNF⇅,
2907- LT,    Protective effect of luteolin against oxidative stress‑mediated cell injury via enhancing antioxidant systems
- in-vitro, Nor, NA
*ROS↓, *Casp9↓, *Casp3↓, *Bcl-2↑, *BAX↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *HO-1↑, *antiOx↑, *lipid-P↓, *p‑γH2AX↓, eff↑,
3531- Lyco,    Lycopene attenuates the inflammation and apoptosis in aristolochic acid nephropathy by targeting the Nrf2 antioxidant system
- in-vivo, Nor, NA
*NRF2↑, *HO-1↑, *NQO1↑, *ROS↓, *mtDam↓, *Bcl-2↑, *BAX↓, *Casp9↓, *Casp3↓, *Apoptosis↓, *RenoP↑, *lipid-P↓, *SOD↑, *GPx↑, *Inflam↓, *TNF-α↓, *IL6↓, *IL10↓,
3263- Lyco,    Lycopene protects against myocardial ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening
- in-vitro, Nor, H9c2 - in-vitro, Stroke, NA
*Apoptosis↓, *MMP↑, *Cyt‑c↓, *APAF1↓, *cl‑Casp9↓, *cl‑Casp3↓, *Bcl-2↑, *BAX↓, cardioP↑,
3277- Lyco,    Recent trends and advances in the epidemiology, synergism, and delivery system of lycopene as an anti-cancer agent
- Review, Var, NA
antiOx↑, TumCP↓, Apoptosis↑, TumMeta↑, ChemoSen↑, BioAv↓, Dose↝, BioAv↓, BioAv↑, SOD↑, Catalase↑, GPx↑, IL2↑, IL4↑, IL1↑, TNF-α↑, GSH↑, GPx↑, GSTA1↑, GSR↑, PPARγ↑, Casp3↑, NF-kB↓, COX2/PTGS2↓, Bcl-2↑, BAX↓, P53↓, CHK1↓, Chk2↓, γH2AX↓, DNAdam↓, ROS↓, P21↑, PCNA↓, β-catenin/ZEB1↓, PGE2↓, ERK↓, cMyc↓, cycE/CCNE↓, JAK1↓, STAT3↓, SIRT1↑, cl‑PARP↑, cycD1/CCND1↓, TNF-α↓, IL6↓, p65↓, MMP2↓, MMP9↓, Wnt↓,
4112- MF,    Novel protective effects of pulsed electromagnetic field ischemia/reperfusion injury rats
- in-vivo, Stroke, NA
*cardioP↑, *Bcl-2↑, *BAX↓, *ROS↓,
98- QC,    Quercetin postconditioning attenuates myocardial ischemia/reperfusion injury in rats through the PI3K/Akt pathway
- in-vivo, Stroke, NA
*Bcl-2↑, *BAX↓, *Bax:Bcl2↓, *cardioP↑, *Akt↑, *PI3K↑, *LDH↓,
79- QC,    Chemopreventive Effect of Quercetin in MNU and Testosterone Induced Prostate Cancer of Sprague-Dawley Rats
- in-vivo, Pca, NA
GSH↑, SOD↑, Catalase↑, GPx↑, GSR↑, IGF-1R↓, Akt↓, AR↓, TumCP↓, lipid-P↓, H2O2↓, Raf↓, p‑MEK↓, Bcl-2↑, Bcl-xL↑, Casp3↑, Casp8↑, Casp9↑,
4286- RES,    Neuroprotective Properties of Resveratrol and Its Derivatives—Influence on Potential Mechanisms Leading to the Development of Alzheimer’s Disease
- Review, AD, NA
*neuroP↑, *Inflam↓, *antiOx↑, *GSH↑, *HO-1↑, *iNOS↓, *BDNF↑, *p‑CREB↑, *PKA↑, *Bcl-2↑, *BAX↓, *IL1β↓, *IL6↓, *MMP9↓, *memory↑, *AMPK↑, *PGC-1α↓, *NF-kB↓, *Aβ↓, *SIRT1↑, *p‑tau↓, *PP2A↑, *lipid-P↓, *NLRP3↓, *BACE/β-secretase↓,
3025- RosA,    Rosmarinic acid alleviates intestinal inflammatory damage and inhibits endoplasmic reticulum stress and smooth muscle contraction abnormalities in intestinal tissues by regulating gut microbiota
- in-vivo, IBD, NA
*GutMicro↑, *ROCK1↓, *Rho↓, *CaMKII ↓, *Zeb1↓, *ZO-1↓, *E-cadherin↓, *IL1β↓, *IL6↓, *TNF-α↓, *GRP78/BiP↓, *PERK↓, *IRE1↓, *ATF6↓, *CHOP/DDIT3↓, *Casp12↓, *Casp9↓, *BAX↓, *Casp3↓, *Cyt‑c↓, *RIP1↓, *MLKL↓, *IL10↑, *Bcl-2↑, *ER Stress↓,

Showing Research Papers: 1 to 50 of 63
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 63

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

BMP7/OP1↓, 1,   miR-375↝, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↓, 1,   Catalase↑, 2,   GPx↑, 4,   GSH↓, 1,   GSH↑, 2,   GSR↑, 2,   GSTA1↑, 1,   H2O2↓, 1,   lipid-P↓, 2,   MDA↑, 1,   ROS↓, 1,   ROS↑, 8,   SOD↓, 1,   SOD↑, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   CDC2↑, 1,   p‑MEK↓, 1,   MMP↓, 2,   mtDam↑, 1,   OCR↓, 1,   Raf↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

cMyc↓, 4,   Glycolysis↓, 1,   PPARγ↑, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 4,   p‑Akt↓, 2,   p‑Akt↑, 1,   Apoptosis↓, 1,   Apoptosis↑, 9,   mt-Apoptosis↑, 1,   Bak↓, 1,   BAX↓, 1,   BAX↑, 6,   Bcl-2↓, 2,   Bcl-2↑, 12,   cl‑Bcl-2↑, 1,   Bcl-xL↓, 1,   Bcl-xL↑, 1,   BID↑, 1,   Casp↑, 3,   Casp1↑, 1,   Casp3↑, 11,   Casp3∅, 1,   cl‑Casp3↑, 1,   Casp8↑, 4,   Casp9↑, 5,   Casp9∅, 1,   Chk2↓, 1,   Cyt‑c↑, 2,   Cyt‑c?, 1,   Diablo↑, 1,   DR4↑, 1,   DR5↑, 1,   Fas↑, 1,   IAP1↓, 1,   ICAD↓, 1,   JNK↑, 1,   p38↑, 2,   survivin↓, 3,   TNFR 1↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

cSrc↓, 1,   HER2/EBBR2↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

pRB↑, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   HSP90↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3II↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

CHK1↓, 1,   DNAdam↓, 1,   DNAdam↑, 1,   P53↓, 1,   P53↑, 4,   PARP↑, 1,   cl‑PARP↑, 5,   cl‑PARP∅, 1,   PCNA↓, 3,   γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CycB/CCNB1↑, 1,   cycD1/CCND1↓, 1,   cycD1/CCND1↑, 1,   cycE/CCNE↓, 1,   P21↑, 4,   TumCCA↑, 7,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH1A1↓, 1,   ERK↓, 2,   ERK↑, 1,   FGF↓, 1,   GSK‐3β↓, 1,   IGF-1R↓, 1,   mTOR↓, 2,   PI3K↓, 3,   STAT3↓, 2,   STAT3↑, 1,   p‑STAT3↓, 1,   TumCG↓, 2,   Wnt↓, 3,  

Migration(tgid=13) ⓘ

CEA↓, 1,   E-cadherin↓, 1,   MMP2↓, 2,   MMP9↓, 3,   MMPs↓, 1,   TIMP2↑, 1,   TumCP↓, 7,   TumMeta↓, 2,   TumMeta↑, 1,   VCAM-1↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 4,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   EGFR↓, 1,   EGFR↑, 1,   EPR↑, 1,   Hif1a↓, 1,   NO↑, 1,   VEGF↓, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 3,   ICAM-1↓, 1,   IKKα↓, 1,   IL1↑, 1,   IL2↑, 1,   IL4↑, 1,   IL6↓, 1,   Inflam↓, 1,   JAK1↓, 1,   JAK2↓, 1,   NF-kB↓, 3,   NF-kB↑, 1,   p65↓, 1,   PGE2↓, 1,   TNF-α↓, 1,   TNF-α↑, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 1,   BioAv↝, 1,   ChemoSen↑, 4,   Dose?, 1,   Dose↝, 1,   eff↓, 3,   eff↑, 4,   RadioS↑, 2,   selectivity↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   CEA↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 1,   EGFR↑, 1,   HER2/EBBR2↓, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 3,   cardioP↑, 1,   chemoP↑, 1,   QoL↑, 1,   radioP↑, 1,   RenoP↑, 1,   TumVol↓, 2,   TumW↓, 1,  
Total Targets: 166

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 2,   diuretic↑, 1,   Learn↑, 1,   NeuroI↓, 1,   SpO2↑, 1,   Stroke↓, 3,   SYP↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 13,   Catalase↓, 1,   Catalase↑, 10,   Fenton↓, 1,   GPx↓, 1,   GPx↑, 9,   GSH↑, 13,   GSR↑, 1,   GSTs↑, 1,   HO-1↑, 11,   HO-2↓, 1,   Keap1↑, 1,   lipid-P↓, 8,   MDA↓, 14,   MPO↓, 2,   NOX4↓, 2,   NQO1↑, 4,   NRF2↑, 12,   RNS↓, 2,   ROS↓, 25,   SIRT3↑, 1,   SOD↓, 1,   SOD↑, 18,   TAC↑, 1,   TBARS↓, 2,   uricA↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,   IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 3,   MMP↑, 3,   mtDam↓, 1,   OCR↑, 1,   PGC-1α↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 2,   AMPK↑, 1,   p‑CREB↑, 2,   GAPDH↑, 1,   glucose↓, 1,   LDH↓, 1,   LDL↓, 1,   NADPH↓, 1,   PFK↓, 1,   PPARγ↑, 2,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

Akt↑, 5,   p‑Akt↓, 1,   p‑Akt↑, 4,   APAF1↓, 2,   Apoptosis↓, 15,   BAX↓, 27,   BAX↑, 1,   Bax:Bcl2↓, 2,   Bcl-2↑, 37,   Bcl-xL↑, 1,   Casp1↓, 1,   Casp12↓, 1,   Casp3↓, 16,   cl‑Casp3↓, 5,   Casp9↓, 6,   cl‑Casp9↓, 2,   Cyt‑c↓, 5,   GSDMD↓, 1,   iNOS↓, 7,   JNK↓, 3,   MLKL↓, 1,   p38↓, 1,   p‑p38↓, 1,   RIP1↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

CaMKII ↓, 1,   p‑p70S6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 3,   ER Stress↓, 1,   GRP78/BiP↓, 3,   HSP70/HSPA5↑, 1,   IRE1↓, 1,   PERK↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 3,   P53↓, 1,   P53↑, 1,   PARP↓, 1,   cl‑PARP↓, 1,   p‑γH2AX↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 1,   GSK‐3β↓, 2,   GSK‐3β↑, 1,   p‑GSK‐3β↑, 2,   HDAC2↓, 1,   Mst1↓, 1,   mTOR↑, 1,   p‑mTOR↓, 1,   p‑mTOR↑, 1,   Nestin↑, 1,   NOTCH1↑, 1,   PI3K↑, 5,   SOX2↑, 1,   STAT3↑, 2,  

Migration(tgid=13) ⓘ

APP↓, 1,   BACH1↓, 1,   Ca+2↓, 1,   E-cadherin↓, 1,   Ki-67↑, 1,   MMP13↓, 1,   MMP9↓, 1,   PKA↑, 1,   RAGE↓, 1,   Rho↓, 1,   ROCK1↓, 1,   Treg lymp↝, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,   VCAM-1↓, 1,   Zeb1↓, 1,   ZO-1↓, 1,   ZO-1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

eNOS↑, 1,   NO↓, 3,   NO↑, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   BBB↝, 1,   GastroP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ASC↓, 1,   CD25+↑, 1,   CD4+↑, 2,   COX2/PTGS2↓, 6,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IL1↓, 1,   IL10↓, 2,   IL10↑, 2,   IL1β↓, 10,   IL1β↑, 1,   IL4↑, 1,   IL6↓, 9,   IL6↑, 1,   IL8↓, 2,   Imm↑, 1,   Inflam↓, 16,   JAK2↑, 1,   M2 MC↑, 1,   MCP1/CCL2↓, 1,   MIP‑1α/CCL3↓, 1,   NF-kB↓, 8,   PGE2↓, 1,   TLR4↓, 1,   TNF-α↓, 17,   TRAF1↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

NOX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 6,   BChE↓, 2,   BDNF↑, 5,   BDNF⇅, 1,   ChAT↑, 1,   MAOA↓, 1,   NGF↑, 3,   PSD95↑, 1,   tau↓, 2,   p‑tau↓, 3,   TrkB↑, 2,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 6,   BACE/β-secretase↓, 3,   MAOB↓, 2,   NLRP3↓, 3,   PP2A↑, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 6,   BioAv↝, 3,   Dose↓, 1,   Dose↑, 2,   Dose↝, 2,   eff↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   ALP↓, 1,   AST↓, 4,   creat↓, 1,   Ferritin↑, 1,   GutMicro↑, 3,   IL6↓, 9,   IL6↑, 1,   Ki-67↑, 1,   LDH↓, 1,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 2,   ANXi↓, 1,   cardioP↑, 10,   cognitive↑, 8,   hepatoP↓, 1,   hepatoP↑, 4,   memory↑, 9,   motorD↑, 2,   neuroP↑, 11,   Obesity↓, 2,   OS↑, 1,   Pain↓, 1,   radioP↑, 1,   RenoP↓, 1,   RenoP↑, 4,   toxicity↓, 3,   Weight↓, 1,   Weight↑, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 2,   CD8+↑, 1,   Inf↓, 1,   Sepsis↓, 1,  
Total Targets: 222

Scientific Paper Hit Count for: Bcl-2, B-cell CLL/lymphoma 2
5 Shikonin
3 Ginkgolide B
3 Lycopene
2 Biochanin A
2 α-Bisabolol / Chamomile oil
2 EGCG (Epigallocatechin Gallate)
2 Emodin
2 Hydrogen Gas
2 Hyperoside
2 isoorientin
2 Quercetin
2 Silymarin (Milk Thistle) silibinin
2 Taurine
2 Thymoquinone
1 Silver-NanoParticles
1 Artemisinin
1 Allicin (mainly Garlic)
1 Ashwagandha(Withaferin A)
1 Baicalein
1 Betulinic acid
1 Boswellia (frankincense)
1 Capsaicin
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorophyllin
1 Chrysin
1 Cichoric acid / Chicoric acid
1 methotrexate
1 Cinnamon
1 Crocetin
1 Carvone
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Curcumin
1 Formononetin
1 Ginkgo biloba
1 Radiotherapy/Radiation
1 Ginger/6-Shogaol/Gingerol
1 Ginkgetin
1 Grapeseed extract
1 hydrogen sulfide
1 Honokiol
1 Huperzine A/Huperzia serrata
1 Isoliquiritigenin
1 Luteolin
1 Magnetic Fields
1 Resveratrol
1 Rosmarinic acid
1 doxorubicin
1 Selenite (Sodium)
1 Urolithin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:27  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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