SMAD4 Cancer Research Results

SMAD4, SMAD family member 4: Click to Expand ⟱
Source: CGL-Driver Genes
Type: TSG
SMAD4 is a critical tumor suppressor gene that plays a significant role in the TGF-β signaling pathway, which regulates various cellular processes, including cell growth, differentiation, and apoptosis.
Plays a critical role in the TGF-beta signaling pathway.
Scientific Papers found: Click to Expand⟱
3501- MF,    Unveiling the Power of Magnetic-Driven Regenerative Medicine: Bone Regeneration and Functional Reconstruction
- Review, NA, NA
*VEGF↑, Releasing VEGF under magnetic stimulation;
*BMPs↓, sinusoidal EMF promotes osteogenic differentiation of BMSCs by up-regulating the gene expression of BMP receptors (BMPR1A, BMPR1B, and BMPR2) and associated signaling components (Smad4 and Smad1/5/8) (
*SMAD4↑,
*SMAD5↑,
*Ca+2↑, PEMFs cause Ca2+ influx in MSCs and stimulate them through pathways such as Wnt/β-catenin and BMP, thereby promoting their osteogenic differentiation.

2945- PL,    Piperlongumine induces ROS mediated cell death and synergizes paclitaxel in human intestinal cancer cells
- in-vitro, CRC, HCT116
ROS↑, Piperlongumine (PL) kills intestinal cancer cells by elevating ROS levels.
SMAD4↑, PL significantly up-regulates SMAD4 expression, leading to apoptosis in cancer cells.
ChemoSen↑, PL with Paclitaxel can be a better option for chemotherapy.
P53↑, Remarkably, P53, P21, BAX, and SMAD4 were significantly upregulated after PL treatment whereas; BCL2 and SURVIVIN were down-regulated.
P21↑,
BAX↑,
Bcl-2↓,
survivin↓,
TumCMig↓, Piperlongumine suppresses migration of cancer cell


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Cell Death ⓘ

BAX↑, 1,   Bcl-2↓, 1,   survivin↓, 1,  

DNA Damage & Repair ⓘ

P53↑, 1,  

Cell Cycle & Senescence ⓘ

P21↑, 1,  

Migration ⓘ

SMAD4↑, 1,   TumCMig↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Migration ⓘ

Ca+2↑, 1,   SMAD4↑, 1,   SMAD5↑, 1,  

Angiogenesis & Vasculature ⓘ

VEGF↑, 1,  

Clinical Biomarkers ⓘ

BMPs↓, 1,  
Total Targets: 5

Scientific Paper Hit Count for: SMAD4, SMAD family member 4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:284  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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