STK11/LKB1 Cancer Research Results

STK11/LKB1, serine/threonine kinase 11: Click to Expand ⟱
Source: CGL-Driver Genes
Type: TSG
Also known as serine/threonine kinase 11
STK11, also known as LKB1 (Liver Kinase B1), is a tumor suppressor gene that plays a crucial role in regulating cell metabolism, growth, and polarity.
Enzymatic activity is crucial for regulating various cellular processes, including metabolism, cell growth, and cell cycle progression. The gene's role as a tumor suppressor is linked to its ability to control these processes, and mutations in STK11 can lead to the development of various cancers. In many cancers, particularly those associated with mutations in the STK11 gene, there is often a loss of STK11 expression or function.
Scientific Papers found: Click to Expand⟱
7630- Ins,    Modulation of both Insulin Resistance and Cancer Growth by Inositol
- Review, Var, NA - Review, Diabetic, NA
*IRes↓, number of synthetic and natural insulin sensitizers, including inositol, have been recognized to exert both anti-diabetic as well as anti-cancer properties.
*AntiDiabetic↑,
*glucose↝, beneficial effect of inositol in fostering glucose homeostasis as well as in antagonizing cancer growth.
AntiCan↑,
PI3K↓, NOSITOL INHIBITS THE PI3K/AKT PATHWAY IN CANCER CELLS
Akt↓,
Glycolysis↓, On the contrary, in cancer cells, IPGs and myo-Ins inhibits Akt reducing both glycolysis and glucose entry in the cell, while re-establishing the oxidative degradation of carbohydrates along the TCA.
STK11/LKB1↑, As inositol enhances specifically the LKB1 activity, it is worth noting that the AMPK-related anticancer activities are tightly dependent of that pathway
*FASN↓, Inositol inhibits fatty acids biosynthesis and reduces plasma LDL-cholesterol and non-esterified fatty acids (NEFA) levels [74-76].
*LDL↓,
*FFA/NEFA↓,
*ROS↓, Myo-Ins counteracts oxidative damage in fish exposed to environmental oxidative stress
ROS↑, anti-oxidant effects seem to be contextdependent, given that in cancer cells inositol actually increases free radical production
IGF-1↓, Furthermore, myoIns may likely inhibit IGF-1 release downstream of the induced inhibition

7800- ISQ,    Isoquercitrin Attenuates Oxidative Liver Damage Through AMPK-YAP Signaling: An Integrative In Silico, In Vitro, and In Vivo Study
- vitro+vivo, Nor, HepG2
*antiOx↑, Isoquercitrin, a flavonoid glycoside found in various plants, has demonstrated antioxidant, anti-inflammatory, and anticancer properties
*Inflam↓,
*AntiCan↑,
*ROS↓, HepG2 cells exposed to arachidonic acid (AA) and iron exhibited oxidative stress-induced apoptosis, which was significantly attenuated by isoquercitrin treatment
*MMP↑, Isoquercitrin decreased reactive oxygen species (ROS) generation and preserved mitochondrial function in a dose-dependent manner.
*STK11/LKB1↑, isoquercitrin activates the LKB1/AMPK pathway, increasing phosphorylation of AMPK and its downstream target ACC, thereby modulating energy metabolism and reducing oxidative stress.
*AMPK↑,
*p‑AMPK↑,
*ACC↑,
*ALAT↓, isoquercitrin protected mice against carbon tetrachloride-induced liver injury, reducing serum ALT and AST levels and improving histopathological features.
*AST↓,
*hepatoP↑, isoquercitrin exerts hepatoprotective effects by activating the LKB1/AMPK pathway and modulating metabolic enzymes, highlighting its potential as a therapeutic agent against oxidative liver damage.


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

Glycolysis↓, 1,   STK11/LKB1↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1↓, 1,   PI3K↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

FFA/NEFA↓, 1,   IRes↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   ROS↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↑, 1,   ALAT↓, 1,   AMPK↑, 1,   p‑AMPK↑, 1,   FASN↓, 1,   glucose↝, 1,   LDL↓, 1,   STK11/LKB1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 1,   hepatoP↑, 1,  
Total Targets: 19

Scientific Paper Hit Count for: STK11/LKB1, serine/threonine kinase 11
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:296  State#:%  Dir#:2
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