TumCM/A Cancer Research Results

TumCM/A, Tumor cell metabolism/acidosis: Click to Expand ⟱
Source: HalifaxProj(normalize)
Type:
Acidosis in the Tumor Microenvironment
Lactic Acidosis: The increased glycolytic activity in tumors leads to the accumulation of lactic acid, resulting in a lower pH in the tumor microenvironment. This lactic acidosis can have several effects on tumor behavior and the surrounding tissue.
Scientific Papers found: Click to Expand⟱
709- Bor,    Cellular changes in boric acid-treated DU-145 prostate cancer cells
- in-vitro, Pca, DU145
Cyc↓, dose-dependent reduction in cyclins A–E
MAPK↓,
TumCMig↓,
LAMP2↓,
p‑ERK⇅, Phosphorylated ERK (P-ERK1/2) increased at intermediate exposures (100 and 250 μM), relative to control, but was reduced by higher concentrations of BA
TumCM/A↑, BA induces media acidosis


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

TumCM/A↑, 1,  

Cell Death ⓘ

MAPK↓, 1,  

Autophagy & Lysosomes ⓘ

LAMP2↓, 1,  

Cell Cycle & Senescence ⓘ

Cyc↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑ERK⇅, 1,  

Migration ⓘ

TumCMig↓, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: TumCM/A, Tumor cell metabolism/acidosis
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:325  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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