PDCD4 Cancer Research Results

PDCD4, PDCD4 Programmed Cell Death 4: Click to Expand ⟱
Source:
Type:
PDCD4 (Programmed Cell Death 4) is a protein that has been studied for its role in cancer biology. It is known to function as a tumor suppressor, meaning it helps prevent the formation and growth of tumors. PDCD4 is involved in various cellular processes, including apoptosis (programmed cell death), cell proliferation, and the regulation of gene expression.

In many cancer types (such as lung, breast, colorectal, and ovarian cancers), PDCD4 expression is decreased relative to normal tissues.
– Loss or reduced expression of PDCD4 is frequently observed at the mRNA and protein levels in tumor samples.
Scientific Papers found: Click to Expand⟱
90- QC,  HP,    Combination of quercetin and hyperoside inhibits prostate cancer cell growth and metastasis via regulation of microRNA‑21
- in-vitro, Pca, PC3
ROS↑, QH decreased the production of reactive oxygen species (ROS) and increased antioxidant capacity in PC3 cells at various concentrations (2.5‑60 µg/ml) with peak inhibition and augmentation changes of 3.22‑ and 3.00‑fold, respectively.
cl‑Casp3↑, activated/cleaved caspase-3 levels were found to be elevated at low concentration of QH (5 and 10 μg/ml) by ~1.5-fold and at higher concentrations (20 and 40 μg/ml) by ~2.7-fold (Fig. 2E). Poly(adenosine diphosphate ribose)
cl‑PARP↑, analysis revealed an increase in PARP cleavage in PC3 cells following QH treatment
miR-21↓, dose-dependent decrease in miR-21 expression, with inhibition rates of 42, 56 and 77% observed at 5, 10 and 20 μg/ml QH, respectively
PDCD4↑,
TAC↑,
tumCV↓, QH inhibits PC3 cell viability.
TumCI↓, QH inhibits the invasive activity of PC3 cells.


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,   TAC↑, 1,  

Cell Death ⓘ

cl‑Casp3↑, 1,   PDCD4↑, 1,  

Transcription & Epigenetics ⓘ

miR-21↓, 1,   tumCV↓, 1,  

DNA Damage & Repair ⓘ

cl‑PARP↑, 1,  

Migration ⓘ

TumCI↓, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PDCD4, PDCD4 Programmed Cell Death 4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:333  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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