PDGF Cancer Research Results

PDGF, Platelet-derived growth factors: Click to Expand ⟱
Source:
Type:
Activation of the PDGF/PDGFR signaling pathway is associated with cancer proliferation, metastasis, invasion, and angiogenesis.

Many tumor types exhibit increased PDGF ligand and/or receptor expression, leading to autocrine or paracrine stimulation of cancer cells as well as the surrounding stromal cells.
– High PDGF signaling is noted in gliomas, sarcomas, breast cancer, and other solid tumors, where it contributes to tumor growth and angiogenesis.
Scientific Papers found: Click to Expand⟱
3480- MF,    Cellular and Molecular Effects of Magnetic Fields
- Review, NA, NA
ROS↑, *Ca+2↑, *Inflam↓, *Akt↓, *mTOR↓, selectivity↑, *memory↑, *MMPs↑, *VEGF↑, *FGF↑, *PDGF↑, *TNF-α↑, *HGF/c-Met↑, *IL1↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Drug Metabolism & Resistance ⓘ

selectivity↑, 1,  
Total Targets: 2

Pathway results for Effect on Normal Cells:


Cell Death ⓘ

Akt↓, 1,   HGF/c-Met↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

FGF↑, 1,   mTOR↓, 1,  

Migration ⓘ

Ca+2↑, 1,   MMPs↑, 1,   PDGF↑, 1,  

Angiogenesis & Vasculature ⓘ

VEGF↑, 1,  

Immune & Inflammatory Signaling ⓘ

IL1↑, 1,   Inflam↓, 1,   TNF-α↑, 1,  

Functional Outcomes ⓘ

memory↑, 1,  
Total Targets: 12

Scientific Paper Hit Count for: PDGF, Platelet-derived growth factors
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:361  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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