IL8 Cancer Research Results

IL8, Interleukin-8: Click to Expand ⟱
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Interleukin-8 (IL-8), also known as CXCL8, is a chemokine primarily involved in the recruitment and activation of neutrophils. Its role in cancer is significant, as it can influence tumor growth, metastasis, and the tumor microenvironment.
IL-8 is a chemokine frequently produced in the tumor microenvironment by human malignant cells. IL-8 plays key roles in the immunobiology of human malignancies and resistance to treatments. Circulating IL-8 concentration reflects tumor burden.

In many cancers have elevated levels of IL-8 and are associated with increased tumor aggressiveness, metastasis, and poorer overall survival. Elevated IL-8 often correlates with a more inflammatory tumor microenvironment, which can facilitate tumor progression.
Scientific Papers found: Click to Expand⟱
5470- AF,    Exploring a Therapeutic Gold Mine: The Antifungal Potential of the Gold-Based Antirheumatic Drug Auranofin
- Review, Var, NA
TrxR↓, mechanism of action of auranofin was correlated with thioredoxin reductase inhibition,
other↝, but other modes of action such as interference with mitochondrial protein import and NADH kinase were also described and discussed
IL6↑, Conversely, auranofin stimulated IL-6 and IL-8 secretion in monocytes,
IL8↑,
NK cell⇅, NK activation was only observed at low doses of auranofin, while high doses inhibited NK activity
COX2↓, suppression of pro-inflammatory factors such as COX-2 (cyclooxygenase-2), NOS (nitric oxide synthase), NF-κB (nuclear factor-κB), and TrxR, as well as on the activation of peroxyredoxin-1 and Nrf2 (nuclear factor erythroid 2-related factor 2) [19].
NOS2↓,
NRF2↑,
Prx↑,
Half-Life↑, plasma half-lives of 15–25 days [24]
Dose↝, To avoid frequently occurring diarrhea, oral doses of 3–6 mg per day, or below, should also be considered when repurposing auranofin for the treatment of other human diseases.
ROS↑, Imbalances in this system lead to the accumulation of cytotoxic ROS.
NF-kB↓, Auranofin can bind to IKK, which ultimately leads to NF-κB inhibition

306- AgNPs,    Cancer Therapy by Silver Nanoparticles: Fiction or Reality?
- Analysis, NA, NA
EPR↝, takes advantage of EPR
ROS↑, silver ions drive the formation of ROS, which triggers massive oxidative stress, thereby activating the cellular pathways leading to cell death
IL1↑, IL-1b
IL8↑, IL-8 mRNA levels
ER Stress↑,
MMP9↑, it has been shown that 20 nm AgNPs increase the MMP-9 secretion
MMP↓, loss of mitochondrial membrane potential and mitochondrial structural disorganization, were reported to accompany the AgNP-induced stres
Cyt‑c↑, cytochrome c release from the mitochondria into the cytoplasm and finally to apoptosis
Apoptosis↑,
Hif1a↑, AgNPs were shown to induce HiF-1α activation, thereby ultimately activating autophagy through the AMPK-mTOR pathway in PC-3 prostate cancer cells [89
BBB↑, AgNPs can affect the integrity of the blood–brain barrier and can cross this barrier in vitro through transcytosis
GutMicro↝, AgNP treatments might influence the composition of the gut microbiota,
eff↑, AgNPs are promising tools for targeted delivery
eff↑, the joint application of the nanoparticles and the HDAC inhibitor caused significantly increased ROS levels,
RadioS↑, idea to use AgNPs as radiosensitizers came along with the phenomenon that metals with high atomic numbers are capable of enhancing the effects of radiation

541- Akk,    Akkermansia muciniphila as a Next-Generation Probiotic in Modulating Human Metabolic Homeostasis and Disease Progression: A Role Mediated by Gut-Liver-Brain Axes?
- Review, NA, NA
GutMicro↑,
PD-1↝,
CD8+↑, CD8+ cytotoxic T lymphocytes (CTLs)
IL8↑,

1299- BBR,    Effects of Berberine and Its Derivatives on Cancer: A Systems Pharmacology Review
- Review, NA, NA
TumCCA↑, G1 phase, G0/G1 phase, or G2/M phase
TP53↑,
COX2↓,
Bax:Bcl2↑,
ROS↑,
VEGFR2↓,
Akt↓,
ERK↓,
MMP2↓, Berberine also decreased MMP-2, MMP-9, E-cadherin, EGF, bFGF, and fibronectin in the breast cancer cells.
MMP9↓,
IL8↑,
P21↑,
p27↑,
E-cadherin↓,
Fibronectin↓,
cMyc↓, The results indicated that these derivatives could selectively induce and stabilize the formation of the c-myc in the parallel molecular G-quadruplex. Accordingly, transcription of c-myc was down-regulated in the cancer cell line

2523- H2,    Prospects of molecular hydrogen in cancer prevention and treatment
- Review, Var, NA
ROS↓, previous studies have shown that H2 can selectively scavenge highly toxic reactive oxygen species (ROS) and inhibit various ROS-dependent signaling pathways in cancer cells, thus inhibiting cancer cell proliferation and metastasis.
TumCP↓,
TumMeta↓,
AntiTum↑, Anti-tumor barrier: H2 produced by intestinal flora
GutMicro↑, hydrogen-rich water (HRW) supplementation significantly inhibited the expansion of opportunistic pathogenic E. coli and increased intestinal integrity in mice with colitis
Inflam↓, H2 maintains the integrity of the intestinal barrier, reduces intestinal inflammation and damage in rat
OS↑, inhalation of H2 for 3 h daily significantly prolonged progression-free survival and overall survival in stage IV colon and rectal patients
radioP↑, administration of inhaled H2 during radiotherapy treatment reduced the damage to the hematological and immune systems
selectivity↑, Through these studies, we believe that the ability of H2 to selectively scavenge highly toxic ROS may be the core and fundamental mechanism of its anti-tumor effects, so this paper mainly focuses on this point of discussion.
SOD↑, H2 inhibited ROS expression and increased SOD, IL-1β, IL-8, IL-13, and tumor necrosis factor-α (TNF-α) expression in lung tissue of cancer
IL1β↑,
IL8↑,
TNF-α↑,
neuroP↑, Ono et al. found that 3% H2 inhaled twice daily for 1 h significantly improved vital signs, stroke scale scores, physiotherapy index, and 2-week brain MRI in stroke patients compared with conventional treatment.

4801- Lyco,    Lycopene in the Prevention of Cardiovascular Diseases
- Review, CardioV, NA
*BioAv↝, Taking into account the fact that humans are not able to synthesize lycopene de novo, therefore its supply with food is necessary to take advantage of its pro-health properties.
*cardioP↑, protective effect on cardiovascular diseases
*BioAv↑, It is assumed that thanks to the cis form, lycopene is highly bioavailable in the human diet
*BioAv↑, bioavailability of lycopene as a result of its trans to cis isomerization can be achieved by adding fish oil or olive oil to tomato dishes.
*antiOx↑, Antioxidant Effects of Lycopene
*ROS↓, Lycopene is a highly effective antioxidant that, due to the high reactivity between the long polyene chain and free radicals, enables the elimination of singlet oxygen and the reduction of reactive oxygen species (ROS)
*ARE↑, activating the antioxidant response element (ARE)
*SOD↑, it increases the amount of antioxidant enzymes, which include superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px)
*Catalase↑,
*GPx↑,
*lipid-P↓, figure 3
*COX2↓, lycopene (in the form of watermelon powder) reduced inflammation by reducing the activity of the pro-inflammatory mediator cyclooxygenase 2 (COX-2),
*Inflam↓, Anti-Inflammatory Mechanism of Lycopene
*IL1β↓, inhibits the synthesis and release of pro-inflammatory cytokines, including IL-1β, IL-6, IL-8, and TNF-α.
*IL6↓,
*IL8↑,
*TNF-α↓,
*NF-kB↓, inhibition of the nuclear factor κB (NF-κB)
*BP↓, 15 or 30 mg of lycopene was associated with a significant reduction in systolic BP

1436- SFN,  PacT,  docx,    Sulforaphane enhances the anticancer activity of taxanes against triple negative breast cancer by killing cancer stem cells
- in-vivo, BC, SUM159
NF-kB↓, sulforaphane is capable of preferentially eliminating CSCs, by inhibiting NF-κB p65
ChemoSen↑, combination of docetaxel and sulforaphane exhibits a greater reduction in primary tumor volume
IL6↓, sulforaphane (2.5 μM and 5 μM) reduces the secretion of both IL-6 and IL-8 by 40–90%
IL8↑,


Showing Research Papers: 1 to 7 of 7

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 7

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

NRF2↑, 1,   Prx↑, 1,   ROS↓, 1,   ROS↑, 3,   SOD↑, 1,   TrxR↓, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 1,   Bax:Bcl2↑, 1,   Cyt‑c↑, 1,   p27↑, 1,  

Transcription & Epigenetics ⓘ

other↝, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,  

DNA Damage & Repair ⓘ

TP53↑, 1,  

Cell Cycle & Senescence ⓘ

P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,  

Migration ⓘ

E-cadherin↓, 1,   Fibronectin↓, 1,   MMP2↓, 1,   MMP9↓, 1,   MMP9↑, 1,   TumCP↓, 1,   TumMeta↓, 1,  

Angiogenesis & Vasculature ⓘ

EPR↝, 1,   Hif1a↑, 1,   VEGFR2↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   IL1↑, 1,   IL1β↑, 1,   IL6↓, 1,   IL6↑, 1,   IL8↑, 6,   Inflam↓, 1,   NF-kB↓, 2,   NK cell⇅, 1,   PD-1↝, 1,   TNF-α↑, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   Dose↝, 1,   eff↑, 2,   Half-Life↑, 1,   RadioS↑, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

GutMicro↑, 2,   GutMicro↝, 1,   IL6↓, 1,   IL6↑, 1,   NOS2↓, 1,   TP53↑, 1,  

Functional Outcomes ⓘ

AntiTum↑, 1,   neuroP↑, 1,   OS↑, 1,   radioP↑, 1,  

Infection & Microbiome ⓘ

CD8+↑, 1,  
Total Targets: 58

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   ARE↑, 1,   Catalase↑, 1,   GPx↑, 1,   lipid-P↓, 1,   ROS↓, 1,   SOD↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL1β↓, 1,   IL6↓, 1,   IL8↑, 1,   Inflam↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 2,   BioAv↝, 1,  

Clinical Biomarkers ⓘ

BP↓, 1,   IL6↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,  
Total Targets: 19

Scientific Paper Hit Count for: IL8, Interleukin-8
1 Auranofin
1 Silver-NanoParticles
1 Akkermansia
1 Berberine
1 Hydrogen Gas
1 Lycopene
1 Sulforaphane (mainly Broccoli)
1 Paclitaxel
1 Docetaxel
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:368  State#:%  Dir#:2
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