IL18 Cancer Research Results

IL18, Interleukin 18: Click to Expand ⟱
Source:
Type:
High levels of IL-18 production may play a major role in the growth and metastasis of renal cancer. Higher expression of IL-18 is detected in various cancer cells.

IL-18 is often expressed in various cancers, including melanoma, colorectal cancer, breast cancer, and gastric cancer. Its expression can vary depending on the tumor type and the immune context. Elevated levels of IL-18 are frequently associated with the presence of tumor-infiltrating immune cells and can be produced by both immune and tumor cells.

High levels of IL-18 expression are often associated with a favorable prognosis in various cancers. Elevated IL-18 levels in the tumor microenvironment can correlate with increased immune cell infiltration and better overall survival.
Scientific Papers found: Click to Expand⟱
5734- Buty,    Enhanced production of IL-18 in butyrate-treated intestinal epithelium by stimulation of the proximal promoter region
- vitro+vivo, Nor, NA
*IL18↑, Butyrate and acetate increased intracellular IL-18 content in a time- and dose-dependent fashion.

5733- Buty,  VitB3,    Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis
- in-vivo, CRC, NA
GutMicro↑, Commensal gut microflora and dietary fiber protect against colonic inflammation and colon cancer through unknown targets. Butyrate, a bacterial product from fermentation of dietary fiber in the colon, has been implicated in this process
HCAR2↑, GPR109A is also a receptor for niacin, which is also produced by gut microbiota and suppresses intestinal inflammation.
AntiCan↑, Niacin, a pharmacological Gpr109a agonist, suppressed colitis and colon cancer in a Gpr109a-dependent manner.
Inflam↓, We hypothesized that GPR109A has an anti-inflammatory role in the colon.
IL18↑, Butyrate or Niacin Induces IL-18 Expression in Colonic Epithelium in a Gpr109a-Dependent Manner

4966- PSO,    Psoralidin induces pyroptosis in both tumor cells and macrophages as well as enhances nature killer cell cytotoxicity to suppress hepatocellular carcinoma
- vitro+vivo, HCC, HepG2
Pyro↑, Psoralidin induced pyroptosis and GSDME cleavage in HepG2 and Hepa1–6 cells
TumCG↓, Psoralidin suppressed HCC growth, inducing tumor cell pyroptosis and enhancing the tumor infiltration of T cells and NK cells.
mt-ROS↑, psoralidin induced mitochondrial reactive oxygen species (ROS) production, leading to caspase-3 activation and subsequent GSDME cleavage.
Casp3↑,
cl‑GSDME↑,
IL1β↑, leading to the secretion of interleukin (IL)-1β and IL-18, which promoted natural killer (NK) cell activation
IL18↑,
NK cell↑,


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

mt-ROS↑, 1,  

Cell Death ⓘ

Casp3↑, 1,   cl‑GSDME↑, 1,   Pyro↑, 1,  

Kinase & Signal Transduction ⓘ

HCAR2↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Immune & Inflammatory Signaling ⓘ

HCAR2↑, 1,   IL18↑, 2,   IL1β↑, 1,   Inflam↓, 1,   NK cell↑, 1,  

Clinical Biomarkers ⓘ

GutMicro↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Immune & Inflammatory Signaling ⓘ

IL18↑, 1,  
Total Targets: 1

Scientific Paper Hit Count for: IL18, Interleukin 18
2 Butyrate
1 Vitamin B3,Niacin
1 Psoralidin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:369  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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