CA Cancer Research Results

CA, Carbonic anhydrases: Click to Expand ⟱

Source:

Type:

CA pH Control, Hypoxia Adaptation, and Metastatic Fitness Family of enzymes that catalyze the reversible hydration of carbon dioxide (CO₂) to bicarbonate (HCO₃⁻) and a proton (H⁺).
Carbonic Anhydrase IX (CAIX) is a well-described enzyme in renal cell carcinoma, with its expression being regulated by the hypoxia-inducible factor 1 alpha, it is known for interfering with hypoxia processes.
Carbonic anhydrase 9 (CA9) is a protein to be upregulated under exposure to hypoxic conditions. Hypoxic conditions are known to be associated with resistance to chemotherapy and radiotherapy, and with poor cancer prognosis.
Of the carbonic anhydrases, CA9 and CA12, are transmembrane isozymes that are highly expressed in some tumours, and may be implicated in acidification of the extracellular milieu surrounding cancer cells, thus creating a microenvironment conducive to tumour growth and spread.
Carbonic anhydrase IX, is an endogenous marker for hypoxia.

Scientific Papers found: Click to Expand⟱

5528-

EP,

Nanosecond pulsed electric fields mimic natural cell signal transduction mechanisms

Review,

Var,

Apoptosis↑, CA↑, Wound Healing↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Cell Death ⓘ

Apoptosis↑, 1,

Migration ⓘ

CA↑, 1,

Functional Outcomes ⓘ

Wound Healing↑, 1,
Total Targets: 3

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: CA, Carbonic anhydrases

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells