STAT1 Cancer Research Results

STAT1, Signal transducer and activator of transcription 1: Click to Expand ⟱
Source:
Type:
STAT1 (Signal Transducer and Activator of Transcription 1) is a transcription factor that plays a crucial role in various cellular processes, including immune response, cell growth, and apoptosis.
Unregulated in some cancers.
High STAT1 expression has been associated with improved prognosis and reduced metastasis.
Low STAT1 expression has been linked to poor prognosis and reduced survival.
Scientific Papers found: Click to Expand⟱
5988- Chit,    Chitosan immunomodulation: insights into mechanisms of action on immune cells and signaling pathways
- Review, Var, NA
DDS↑, various biomedical applications, including drug delivery, cartilage repair, wound healing, and tissue engineering, because of its unique physicochemical properties.
*Cartilage↑,
*Wound Healing↑,
Imm↑, investigation of the immunomodulatory properties of chitosan, since the biopolymer has been shown to modulate the maturation, activation, cytokine production, and polarization of dendritic cells and macrophages
cGAS–STING↑, Several signaling pathways, including the cGAS–STING, STAT-1, and NLRP3 inflammasomes, are involved in chitosan-induced immunomodulation. CS activates the cGAS–STING signaling pathway
STAT1↑, One crucial factor is DDA, as it was observed that 80% DDA CS activated the STAT-1 pathway, whereas 98% DDA did not
NLRP3↑, activation of the NLRP3 inflammasome by CS requires the presence of mitochondrial ROS.
*DCells↑, CS has been studied for its potential impact on DC activation, which is a crucial step in initiating the immune response.
*IL10↓, The use of CS also reduced IL-10 production and increased TGF-β1, TNF-α, and interleukin-1 beta (IL-1β) (p < 0.001) levels.
*TGF-β1↓,
*TNF-α↓,
IL1β↓,
ROS↑, CS internalization in DCs caused mitochondrial stress and led to the production of reactive oxygen species (ROS)


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

STAT1↑, 1,  

Immune & Inflammatory Signaling ⓘ

IL1β↓, 1,   Imm↑, 1,  

Cellular Microenvironment ⓘ

cGAS–STING↑, 1,  

Protein Aggregation ⓘ

NLRP3↑, 1,  

Drug Metabolism & Resistance ⓘ

DDS↑, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Migration ⓘ

Cartilage↑, 1,   TGF-β1↓, 1,  

Immune & Inflammatory Signaling ⓘ

DCells↑, 1,   IL10↓, 1,   TNF-α↓, 1,  

Functional Outcomes ⓘ

Wound Healing↑, 1,  
Total Targets: 6

Scientific Paper Hit Count for: STAT1, Signal transducer and activator of transcription 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:370  State#:%  Dir#:2
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