STAT4 Cancer Research Results

STAT4, Signal transducer and activator of transcription 4: Click to Expand ⟱
Source:
Type:
STAT4 (Signal Transducer and Activator of Transcription 4) is a transcription factor that plays a significant role in the immune response and has been implicated in various biological processes, including inflammation and cell proliferation.
High STAT4 expression has been associated with improved prognosis and reduced metastasis.
Scientific Papers found: Click to Expand⟱
5986- Chit,    The natural product chitosan enhances the anti-tumor activity of natural killer cells by activating dendritic cells
- Study, Var, NA
NK cell↑, In this study, we discovered that chitosan enhanced the anti-tumor activity of natural killer (NK) cells by activating dendritic cells (DCs).
IFN-γ↑, In the presence of DCs, chitosan augmented IFN-γ production by human NK cells.
IL12↑, Mechanistically, chitosan activated DCs to express pro-inflammatory cytokines such as interleukin (IL)-12 and IL-15, which in turn activated the STAT4 and NF-κB signaling pathways, respectively, in NK cells.
IL15↑,
STAT4↑,
NF-kB↑, in NK cells
DCells↑, Collectively, our results demonstrate that chitosan activates DCs leading to enhanced capacity for immune surveillance by NK cells.


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Proliferation, Differentiation & Cell State ⓘ

STAT4↑, 1,  

Immune & Inflammatory Signaling ⓘ

DCells↑, 1,   IFN-γ↑, 1,   IL12↑, 1,   IL15↑, 1,   NF-kB↑, 1,   NK cell↑, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: STAT4, Signal transducer and activator of transcription 4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:371  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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