STAT4 Cancer Research Results

STAT4, Signal transducer and activator of transcription 4: Click to Expand ⟱
Source:
Type:
STAT4 (Signal Transducer and Activator of Transcription 4) is a transcription factor that plays a significant role in the immune response and has been implicated in various biological processes, including inflammation and cell proliferation.
High STAT4 expression has been associated with improved prognosis and reduced metastasis.
Scientific Papers found: Click to Expand⟱
5986- Chit,    The natural product chitosan enhances the anti-tumor activity of natural killer cells by activating dendritic cells
- Study, Var, NA
NK cell↑, In this study, we discovered that chitosan enhanced the anti-tumor activity of natural killer (NK) cells by activating dendritic cells (DCs).
IFN-γ↑, In the presence of DCs, chitosan augmented IFN-γ production by human NK cells.
IL12↑, Mechanistically, chitosan activated DCs to express pro-inflammatory cytokines such as interleukin (IL)-12 and IL-15, which in turn activated the STAT4 and NF-κB signaling pathways, respectively, in NK cells.
IL15↑,
STAT4↑,
NF-kB↑, in NK cells
DCells↑, Collectively, our results demonstrate that chitosan activates DCs leading to enhanced capacity for immune surveillance by NK cells.

7445- CYN,    Cynaropicrin Shows Antitumor Progression Potential in Colorectal Cancer Through Mediation of the LIFR/STATs Axis
- vitro+vivo, CRC, RKO - in-vitro, CRC, HCT116 - in-vitro, CRC, DLD1
tumCV↓, Cynaropicrin significantly reduced the survival ability of human CRC cells and promoted apoptosis in a dose-dependent manner.
STAT↓, mediated by inhibition of the LIFR/STATs axis
LIFR/CD118↓,
STAT3↓, Cynaropicrin reduced the formation of STAT3/STAT4 heterodimers and blocked their entry into the nucleus
STAT4↑,
TumCG?, Cynaropicrin also suppressed tumor growth in the xenograft model.
cl‑PARP1↑, changes in the expression levels of Cl-PARP1, Bcl-2, Bax, which are associated with the process of apoptosis
Bcl-2↓,
BAX↑,
STAT3↓, Cynaropicrin Blocked the Activation of STAT3 via Inhibiting LIFR Activity
Dose↝, intraperitoneal administration of cynaropicrin at doses of 2.5 and 5 mg/kg resulted in decreased tumor volume and weight compared to the vehicle group
TumVol↓,
TumW↓,
toxicity↓, potent antitumor activity against the growth of implanted CRC with minimal toxicity in the animal.


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

LIFR/CD118↓, 1,  

Cell Death(tgid=5) ⓘ

BAX↑, 1,   Bcl-2↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

cl‑PARP1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

STAT↓, 1,   STAT3↓, 2,   STAT4↑, 2,   TumCG?, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

DCells↑, 1,   IFN-γ↑, 1,   IL12↑, 1,   IL15↑, 1,   NF-kB↑, 1,   NK cell↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,   TumVol↓, 1,   TumW↓, 1,  
Total Targets: 19

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: STAT4, Signal transducer and activator of transcription 4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

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