AR-V7 Cancer Research Results

AR-V7, androgen receptor splice variant 7: Click to Expand ⟱
Source:
Type:
Accumulating evidence suggests androgen receptor splice variant 7 (AR-V7) may be associated with the prognosis of castration-resistant prostate cancer (CRPC).
AR-V7 is primarily studied in prostate cancer, where it has established prognostic significance. Prostate Cancer
Expression: AR-V7 is often overexpressed in castration-resistant prostate cancer (CRPC). Prognosis: High levels of AR-V7 are associated with poor prognosis, treatment resistance, and shorter overall survival. It is also used as a biomarker to predict response to therapies like enzalutamide and abiraterone.
Scientific Papers found: Click to Expand⟱
75- QC,  ENZ,    Quercetin targets hnRNPA1 to overcome enzalutamide resistance in prostate cancer cells
- in-vitro, Pca, HEK293 - in-vitro, NA, 22Rv1 - in-vitro, NA, C4-2B
hnRNPA1↓, quercetin downregulates hnRNPA1 expression
PSA↓,
NKX3.1↓,
FKBP5↓,
UBE2C↓,
AR-FL↓, FL AR
AR-V7↑, downregulates the expression of AR-V7, antagonizes androgen receptor signaling
AR↓, Quercetin downregulates androgen receptor signaling
eff↑, Quercetin resensitizes enzalutamide-resistant xenografts to enzalutamide in vivo
TumVol↓,
BioAv↓, The bioavailability of quercetin is low as it is present in glycosylated form, which can be readily metabolized by enzymes in the gut and liver, leading to low systemic concentrations in the body


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


DNA Damage & Repair ⓘ

NKX3.1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

AR-FL↓, 1,   AR-V7↑, 1,  

Migration ⓘ

hnRNPA1↓, 1,  

Immune & Inflammatory Signaling ⓘ

PSA↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   FKBP5↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   eff↑, 1,  

Clinical Biomarkers ⓘ

AR↓, 1,   PSA↓, 1,  

Functional Outcomes ⓘ

TumVol↓, 1,   UBE2C↓, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: AR-V7, androgen receptor splice variant 7
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:393  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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