IGF-2 Cancer Research Results

IGF-2, Insulin-like growth factor 2: Click to Expand ⟱
Source:
Type: Oncogene
Insulin-like Growth Factor 2 (IGF-2) is a protein that plays a significant role in growth and development, particularly during fetal development. It is part of the insulin-like growth factor (IGF) family, which includes IGF-1 and IGF-2, and is involved in cellular growth, differentiation, and survival.
-IGF2 is a mitogenic polypeptide that is abundantly expressed in the brain, especially in the cortex and hippocampus, and is required for memory consolidation and enhancement.

IGF-2 is often overexpressed in various human cancers because the dysregulation of the differentially methylated region (DMR) on the maternal chromosome causes loss of imprinting (LOI).

Oncogenic Potential:
IGF-2 is considered an oncogene due to its role in promoting cell proliferation and survival. It activates signaling pathways such as the PI3K/Akt and MAPK pathways, which are critical for cell growth and survival.
The overexpression of IGF-2 can lead to increased tumor cell proliferation, invasion, and metastasis.
High levels of IGF-2 expression are often associated with a poor prognosis in various cancers.


Scientific Papers found: Click to Expand⟱
2039- PB,    TXNIP mediates the differential responses of A549 cells to sodium butyrate and sodium 4‐phenylbutyrate treatment
- in-vitro, Lung, A549 - in-vitro, Nor, HEK293
TXNIP↑, TXNIP was strongly induced by NaBu (30‐ to 40‐fold mRNA) but was only slightly induced by 4PBA (two to fivefold) in A549 cells.
Casp3↑, Additionally, A549 cells that were treated with these showed changes in glucose consumption, caspase 3/7 activation and histone modifications, as well as enhanced mitochondrial superoxide production
Casp7↑,
mt-ROS↑, as well as enhanced mitochondrial superoxide production. 4PBA induced a mitochondrial superoxide‐associated cell death, while NaBu did so mainly through a TXNIP‐mediated pathway
GlucoseCon↓, both NaBu and 4PBA can decrease the glucose consumption compared to the vehicle control
TumCP↓, both inhibitors can prevent A549 cell proliferation and induce cell death
TumCD↑,
IGF-2↑, NaBu and 4PBA induce insulin‐like growth factor 2 (somatomedin A) (IGF2) 31‐fold and 48‐fold (Fig. S1 and S2), respectively.
HDAC↓, As inhibitors of HDACs, NaBu and 4PBA are capable of changing histone modifications
ROS⇅, suggests that 4PBA‐induced ROS generation might be a cell type or concentration dependent


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS⇅, 1,   mt-ROS↑, 1,  

Core Metabolism/Glycolysis ⓘ

GlucoseCon↓, 1,  

Cell Death ⓘ

Casp3↑, 1,   Casp7↑, 1,   TumCD↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC↓, 1,   IGF-2↑, 1,  

Migration ⓘ

TumCP↓, 1,   TXNIP↑, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: IGF-2, Insulin-like growth factor 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:416  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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