Twist Cancer Research Results

Twist, Twist: Click to Expand ⟱
Source:
Type: transcription factor
Twist, the basic helix-loop-helix transcription factor, is involved in the process of epithelial to mesenchymal transitions (EMTs), which play an essential role in cancer metastasis. Overexpression of Twist or its promoter methylation is a common scenario in metastatic carcinomas. Twist is a key transcription factor for Epithelial-mesenchymal transition (EMT).
Twist-1 overexpression was shown, recently, to be a factor of poor prognosis in melanomas Many studies use “TWIST” and “TWIST1” interchangeably (with TWIST1 being the canonical factor in humans.

Twist plays key roles in embryonic development and has been implicated in cancer progression, particularly through promoting epithelial-mesenchymal transition (EMT), invasion, and metastasis. TWIST1 directly represses epithelial markers (e.g., E-cadherin) while upregulating mesenchymal markers (e.g., N-cadherin, vimentin).

Twist is most often upregulated in cancer cells compared to normal cells across multiple tumor types.
– High Twist expression is consistently associated with aggressive clinical features, including increased invasiveness, metastasis, and reduced overall survival.
Scientific Papers found: Click to Expand⟱
1123- aLinA,    Linoleic acid induces an EMT-like process in mammary epithelial cells MCF10A
- in-vitro, BC, NA - in-vitro, NA, MCF10
TumCP↑, Linoleic acid (LA) induces proliferation and invasion in breast cancer cells.
E-cadherin↓,
Snail↑, increase of Snail1, Snail2, Twist1, Twist2 and Sip1 expressions.
Twist↑,
ZEB2↑,
FAK↑,
NF-kB↑,
MMP2↓, Furthermore, LA induces FAK and NFκB activation, MMP-2 and -9 secretions, migration and invasion.
MMP9↓,
*EMT↑, LA promotes an EMT-like process in MCF10A
TumCI↑,

6441- SAO,    Sandalwood Album Oil as a Botanical Therapeutic in Dermatology
- Review, PSA, NA
*Inflam↓, anti-inflammatory, anti-microbial, and anti-proliferative agent.
*eff↑, shown promise in clinical trials for treatment of acne, psoriasis, eczema, common warts, and molluscum contagiosum.
*5LO↓, The oil inhibits the oxidative enzyme 5-lipoxygenase and has DPPH radical scavenging activity and,
*DPPH↓,
*hepatoP↑, in vivo, SAO was able to protect mouse livers from damage resulting from oxidative stress and the formation of reactive oxygen species.
*ROS↓,
*PGE2↓, Production of PGE2 was also suppressed, suggesting that SAO might be acting, at least in part, through inhibition of cyclooxygenase
*IL1β↓, The oil also suppressed the expression of the pro-inflammatory cytokine, IL-1b, in keratinocytes and reduced irritant dermatitis in mouse skin stimulated with haptens.
*IL17↓, reduce levels of IL-17 and the activity of PDE4.
*PDE4↓,
*tyrosinase↓, Alpha-santalol was found to be an inhibitor of tyrosinase, a key enzyme in the biosynthetic pathway for the skin pigment melanin.
*AntiFungal↑, SAO has demonstrated potent activity against many fungal dermatophytes and yeasts including Trichophyton, Microsporum and Candida
angioG↓, alpha-santalol, the primary component of SAO, is anti-angiogenic and inhibits the growth of hepatocellular carcinoma and prostate tumors in vitro and in vivo.
TumCG↓,
DNAdam↑, MCF-7) and non-tumorigenic epithelial breast cells (MCF-10A).42 The authors demonstrated that the oil induced deoxyribonucleic acid (DNA) strand breaks in both cell lines.
*Snail↑, SAO enhanced expression of transcription factors (snail, twist) and mesenchymal factor (vimentin), all of which are related to the epithelial-mesenchymal transition (EMT).
*Twist↑,
*Vim↑,
*EMT↓,
*toxicity↓, other species of sandalwood, such as Western Australian (Santalum spicatum) or Hawaiian sandalwood (Santalum paniculatum), contain significant percentages of farnesol, an irritant, that is not found in oil from S. album.

1135- Selenate,    Selenate induces epithelial-mesenchymal transition in a colorectal carcinoma cell line by AKT activation
- in-vitro, CRC, DLD1
EMT↑, deleterious effects of EMT induction should be taken into careful consideration
Akt↑,
Twist↑, increased expression of the EMT-inducing transcription factor TWIST1
Vim↑,
E-cadherin↓,


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death(tgid=5) ⓘ

Akt↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↑, 1,   TumCG↓, 1,  

Migration(tgid=13) ⓘ

E-cadherin↓, 2,   FAK↑, 1,   MMP2↓, 1,   MMP9↓, 1,   Snail↑, 1,   TumCI↑, 1,   TumCP↑, 1,   Twist↑, 2,   Vim↑, 1,   ZEB2↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NF-kB↑, 1,  
Total Targets: 16

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

DPPH↓, 1,   ROS↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,   EMT↑, 1,   tyrosinase↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   Snail↑, 1,   Twist↑, 1,   Vim↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL17↓, 1,   IL1β↓, 1,   Inflam↓, 1,   PGE2↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1,  

Functional Outcomes(tgid=23) ⓘ

hepatoP↑, 1,   PDE4↓, 1,   toxicity↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,  
Total Targets: 18

Scientific Paper Hit Count for: Twist, Twist
1 alpha Linolenic acid
1 α-Santalol/Sandalwood oil
1 Selenate
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:421  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

Home Page