Ki-67 Cancer Research Results

Ki-67, Ki-67 protein: Click to Expand ⟱
Source:
Type: proliferation marker
A high Ki-67 proliferation index means many cells are dividing quickly and that the cancer is likely to grow and spread.
Markers of proliferation index (Ki-67)

• Ki-67 serves primarily as a proliferation marker: higher levels are generally indicative of aggressive disease and poorer outcomes across many cancer types.
• While Ki-67 itself is not considered a driver of tumorigenesis, its expression mirrors the high proliferative activity associated with protumoral behavior.
• It is widely used in clinical practice to aid in tumor grading, prognostication, and treatment planning.
Scientific Papers found: Click to Expand⟱
5421- ASTX,    Astaxanthin Inhibits PC-3 Xenograft Prostate Tumor Growth in Nude Mice
- in-vivo, Pca, NA
TumCG↑, 100 mg/kg astaxanthin significantly inhibited tumor growth compared to the TC group, with an inhibitory rate of 41.7%.
Ki-67↑, A decrease of Ki67 and proliferating cell nuclear antigen (PCNA) as well as an increase of cleaved caspase-3 were observed in HA-treated tumors
PCNA↓,
GutMicro↑, The HA significantly elevated the levels of tumor suppressors miR-375 and miR-487b in tumor tissues and the amount of Lactobacillus sp. and Lachnospiraceae in mice stools, while there was no significant difference between LA and TC groups.
*Inflam↓, Dietary supplementation with astaxanthin was reported to exert beneficial effects against inflammation, cardiovascular disease, and oxidative damage, suggesting that astaxanthin is a functional food ingredient
*cardioP↑,
*ROS↓,

1190- Gb,    Extract of Ginkgo biloba exacerbates liver metastasis in a mouse colon cancer Xenograft model
- in-vivo, CRC, SW-620
TumMeta↑, EGb significantly increased the rate of metastasis in mouse liver
Ki-67↑, EGb significantly increased the percentage of Ki67-positive cells in liver tumors when compared to tumors from PBS controls

1043- MET,  immuno,    Metformin reduces PD-L1 on tumor cells and enhances the anti-tumor immune response generated by vaccine immunotherapy
- in-vitro, NA, NA
eff↑, metformin can synergize with vaccine immunotherapy to augment the antitumor response
PD-L1↓, Metformin reduces PD-L1 on tumor cells
Ki-67↑, While these effector CD8 T cells have better cytotoxic capabilities,40 the central memory phenotype has better proliferative capabilities, as we observed an increase in Ki-67 expression
TIM-3↑,
L-sel↑,


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


DNA Damage & Repair ⓘ

PCNA↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↑, 1,  

Migration ⓘ

Ki-67↑, 3,   L-sel↑, 1,   TumMeta↑, 1,  

Immune & Inflammatory Signaling ⓘ

PD-L1↓, 1,  

Cellular Microenvironment ⓘ

TIM-3↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  

Clinical Biomarkers ⓘ

GutMicro↑, 1,   Ki-67↑, 3,   PD-L1↓, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

ROS↓, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,  
Total Targets: 3

Scientific Paper Hit Count for: Ki-67, Ki-67 protein
1 Astaxanthin
1 Ginkgo biloba
1 Metformin
1 immunotherapy
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:425  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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