NQO2 Cancer Research Results
NQO2, N-ribosyldihydronicotinamide:quinone reductase 2: Click to Expand ⟱
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Curcumol exhibits synergistic lethal effects with TRAIL on cancer cell by directly targeting quinone oxidoreductase 2 (NQO2) to induce reactive oxygen species, triggering ER stress‐C/EBP homologous protein (CHOP)‐death receptor 5 (DR5) signaling to combat TRAIL‐resistant cancer.
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Scientific Papers found: Click to Expand⟱
NQO1↑, Genistein and quercetin, as individual phytochemicals, increased NQO1 expression by ~3.78- and ~6.42-fold, respectively,
P53↑, Taken together, these results support the existence of synergy between EGCG, genistein and quercetin in the control of AR, p53 and NQO1 expression
NQO2↑,
chemoPv↑, synergy between bioactive dietary agents, thus broadening the chemopreventive index
TumCP↓, Analyzing the results from colony formation and cell proliferation together, the relative potency and efficacy of the three phytochemicals was ranked as EGCG>quercetin>genistein.
AR↓, EGCG or quercetin (2.5 μM) separately, inhibited AR expression by 67% and 47%, respectively compared to the control,
*AntiDiabetic↑, Metformin is a drug commonly prescribed to treat patients with type 2 diabetes.
*AntiAge↑, Here we show that long-term treatment with metformin (0.1% w/w in diet) starting at middle age extends healthspan and lifespan in male mice
*toxicity⇅, while a higher dose (1% w/w) was toxic.
*CRM↑, The effects of metformin resembled to some extent the effects of caloric restriction, even though food intake was increased.
*Strength↑, Treatment with metformin mimics some of the benefits of calorie restriction, such as improved physical performance, increased insulin sensitivity, and reduced LDL and cholesterol levels without a decrease in caloric intake
*LDL↓,
*AMPK↑, metformin increases AMP-activated protein kinase activity and increases antioxidant protection, resulting in reductions in both oxidative damage accumulation and chronic inflammation
*TAC↑,
*ROS↓, consistent with decreased oxidative stress damage in the liver of metformin-treated mice
*Inflam↓, Metformin inhibits chronic inflammation
Risk↓, metformin treatment has been associated with reduced risk of cancer4 and cardiovascular disease
*cardioP↑,
*ALAT↓, Ala aminotransferase (U/L) 90 ± 58 64 ± 29
*NRF2↑, The increase in Nrf2/ARE reporter activity occurred with an ED50 of ~1.5 mM metformin without reduction in cell survival
*SOD2↑, 0.1% metformin contributed to an increase in the level of antioxidant and stress response proteins, including SOD2, TrxR1, NQO1 and NQO2
*TrxR1↑,
*NQO1↑,
*NQO2↑,
Showing Research Papers: 1 to 2 of 2
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress ⓘ
NQO1↑, 1,
Protein Folding & ER Stress ⓘ
NQO2↑, 1,
DNA Damage & Repair ⓘ
P53↑, 1,
Migration ⓘ
TumCP↓, 1,
Hormonal & Nuclear Receptors ⓘ
AR↓, 1,
Clinical Biomarkers ⓘ
AR↓, 1,
Functional Outcomes ⓘ
chemoPv↑, 1, Risk↓, 1,
Total Targets: 8
Pathway results for Effect on Normal Cells:
Redox & Oxidative Stress ⓘ
NQO1↑, 1, NRF2↑, 1, ROS↓, 1, SOD2↑, 1, TAC↑, 1, TrxR1↑, 1,
Core Metabolism/Glycolysis ⓘ
ALAT↓, 1, AMPK↑, 1, CRM↑, 1, LDL↓, 1,
Protein Folding & ER Stress ⓘ
NQO2↑, 1,
Immune & Inflammatory Signaling ⓘ
Inflam↓, 1,
Clinical Biomarkers ⓘ
ALAT↓, 1,
Functional Outcomes ⓘ
AntiAge↑, 1, AntiDiabetic↑, 1, cardioP↑, 1, Strength↑, 1, toxicity⇅, 1,
Total Targets: 18
Scientific Paper Hit Count for: NQO2, N-ribosyldihydronicotinamide:quinone reductase 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
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