NOTCH3 Cancer Research Results

NOTCH3, Notch homolog 3: Click to Expand ⟱
Source:
Type:
NOTCH3 is a member of the Notch signaling pathway, which plays a crucial role in cell communication, development, and differentiation.
NOTCH3 can have both oncogenic (cancer-promoting) and tumor-suppressive roles, depending on the type of cancer and the cellular context.
Overexpression in: breast, ovarian, lung, head and neck, gbm, pancreatic.
Scientific Papers found: Click to Expand⟱
7105- GEN,    Effects of genistein supplementation on genome‑wide DNA methylation and gene expression in patients with localized prostate cancer
- Trial, Pca, NA
Risk↓, high consumption of soy products has been associated with a low incidence of prostate cancer, suggesting a preventive role of genistein in prostate cancer. high intake of soy isoflavones are associated with a 25–30% reduced risk of prostate cancer
Myc↓, Enrichment analysis suggested overall reduction in MYC activity and increased PTEN activity in genistein-treated patients.
PTEN↑,
Dose↝, received 30 mg genistein
NOTCH3↑, our results indicate that genistein intervention induces modulation of several genes, including NOTCH3, JAG1, ADCY4 and NEU1
JAG1↑, figure 2
ADCY4↑,
NEU1↑,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ADCY4↑, 1,   JAG1↑, 1,   NEU1↑, 1,  

Cell Death(tgid=5) ⓘ

Myc↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

NOTCH3↑, 1,   PTEN↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

Myc↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Risk↓, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: NOTCH3, Notch homolog 3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:437  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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