HEY1 Cancer Research Results

HEY1, Hairy/enhancer-of-split related with YRPW motif 1: Click to Expand ⟱
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HEY1 (Hairy/enhancer-of-split related with YRPW motif 1) is a gene that plays a role in various biological processes, including development and cell differentiation.
HEY1 has been found to be overexpressed in various cancers, which can contribute to tumor growth and progression. It may influence pathways related to cell proliferation, apoptosis (programmed cell death), and angiogenesis (the formation of new blood vessels).
HEY1 is often found to be overexpressed in several cancers, including breast cancer, colorectal cancer, and glioblastoma. This overexpression can be associated with aggressive tumor behavior and poor prognosis.

Its overexpression is associated with various cancers, including breast, lung, colorectal, and hepatocellular carcinoma, often correlating with poor prognosis and aggressive tumor behavior.
Scientific Papers found: Click to Expand⟱
3469- MF,    Pulsed Electromagnetic Fields (PEMF)—Physiological Response and Its Potential in Trauma Treatment
- Review, NA, NA
*eff↑, According to this analysis, pulse repetition frequencies higher than 100 Hz with magnet flux densities between 1 mT and 10 mT lead to the highest presence of a cellular response, although this may vary depending on the cell type and stage of growth
*eff↝, Also, repeated applications over a prolonged period of more than 10 days show a higher effect than shorter periods, while a prolonged acute exposure lasting more than 24 h seems to be less effective than an acute exposure with less than 24 h applicat
*other↑, release of Ca2+ ion and the direct activation of PEMF on voltage-gated calcium channels (VGCCs) is of great relevance.
Ca+2↑, PEMF stimulation also leads to similar membrane effects, resulting in a Ca2+ influx, which triggers further cellular signals
ROS↑, It has been proposed that the accumulation of ROS or oxidative stress may cause the upregulation of heat shock proteins (Hsp70, HIF-1), leading to cell damage.
HSP70/HSPA5↑,
*NOTCH↑, PEMF has been shown to increase the expressions of Notch4 and Hey1 during osteogenic differentiation of MSCs, suggesting that the Notch pathway, important in cellular fate and bone development, is activated by PEMF in stem cells
*HEY1↑,
*p38↑, PEMF-induced osteogenic differentiation MSCs, as well as the activation of p38 MAPK
*MAPK↑,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Protein Folding & ER Stress ⓘ

HSP70/HSPA5↑, 1,  

Migration ⓘ

Ca+2↑, 1,  
Total Targets: 3

Pathway results for Effect on Normal Cells:


Cell Death ⓘ

HEY1↑, 1,   MAPK↑, 1,   p38↑, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

NOTCH↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,   eff↝, 1,  
Total Targets: 7

Scientific Paper Hit Count for: HEY1, Hairy/enhancer-of-split related with YRPW motif 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:438  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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