Casp9 Cancer Research Results

Casp9, Caspase-9: Click to Expand ⟱

Source:

Type:

Caspase-9 is the apoptotic initiator protease of the intrinsic or mitochondrial apoptotic pathway, which is activated at multi-protein activation platforms.
Caspases are divided into two groups: the initiator caspases (caspase-2, -8, -9 and -10), which are the first to be activated in response to a signal, and the executioner caspases (caspase-3, -6, and -7) that carry out the demolition phase of apoptosis.
Caspase-9:
Role: Initiator caspase in the intrinsic apoptotic pathway.
Cancers: Frequently studied in leukemia and solid tumors.
Prognosis: Reduced expression is often linked to chemoresistance and poor prognosis.

Scientific Papers found: Click to Expand⟱

1295-

AG,

Cisplatin,

Chemosensitizing Effect of Astragalus Polysaccharides on Nasopharyngeal Carcinoma Cells by Inducing Apoptosis and Modulating Expression of Bax/Bcl-2 Ratio and Caspases

-

in-vivo,

Laryn,

NA

mice

AntiTum↑, Apoptosis↑, Bcl-2↓, BAX↑, Casp3↑, Casp9↑, Bax:Bcl2↑,

5431-

AG,

Advances in research on the anti-tumor mechanism of Astragalus polysaccharides

-

Review,

Var,

NA

AntiTum↑, TumCG↓, TumCI↓, Apoptosis↑, Imm↑, Bcl-2↓, BAX↑, Wnt↓, β-catenin/ZEB1↓, TumCG↓, miR-133a-3p↑, JNK↓, Fas↑, P53↑, P21↑, NOTCH1↓, NOTCH3↓, TumCP↓, TumCCA↑, GPx4↓, xCT↓, AMPK↑, Beclin-1↑, NF-kB↓, EMT↓, Vim↓, TumMeta↓, VEGF↓, EGFR↓, eff↑, eff↑, MMP↓, P-gp↓, MMP9↓, ChemoSen↑, SIRT1↓, SREBP1↓, TumAuto↑, PI3K↓, mTOR↓, Casp3↑, Casp9↑, CD133↓, CD44↓, CSCs↓, QoL↑,

5238-

AgNPs,

β-Sitosterol-assisted silver nanoparticles activates Nrf2 and triggers mitochondrial apoptosis via oxidative stress in human hepatocellular cancer cell line

-

in-vitro,

HCC,

HepG2

TumCP↓, ROS↑, NRF2↑, BAX↑, P53↑, Cyt‑c↑, Casp9↑, Casp3↑, Bcl-2↓,

4438-

AgNPs,

ART/DHA,

Biogenic synthesis of AgNPs using Artemisia oliveriana extract and their biological activities for an effective treatment of lung cancer

-

in-vitro,

Lung,

A549

EPR↑, BAX↑, Bcl-2↑, Casp3↑, Casp9↑, DNAdam↑, TumCCA↑, Apoptosis↑,

5145-

AgNPs,

Silver nanoparticles induce irremediable endoplasmic reticulum stress leading to unfolded protein response dependent apoptosis in breast cancer cells

-

in-vitro,

BC,

MCF-7

-

in-vitro,

BC,

T47D

Bacteria↓, Apoptosis↑, ER Stress↑, UPR↑, PERK↑, IRE1↑, ATF6↑, ATF4↑, CHOP↑, Casp9↑, Casp7↑, Mcl-1↓, XIAP↓, PARP↝, selectivity↑,

334-

AgNPs,

Silver-Based Nanoparticles Induce Apoptosis in Human Colon Cancer Cells Mediated Through P53

-

in-vitro,

Colon,

HCT116

Bax:Bcl2↑, P53↑, P21↑, Casp3↑, Casp8↑, Casp9↑, Akt↓, NF-kB↓, DNAdam↑, TumCCA↑,

327-

AgNPs,

MS-275,

Combination Effect of Silver Nanoparticles and Histone Deacetylases Inhibitor in Human Alveolar Basal Epithelial Cells

-

in-vitro,

Lung,

A549

 1uM,1uM

Apoptosis↑, ROS↑, LDH↓, TNF-α↑, mtDam↑, TumAuto↑, Casp3↑, Casp9↑, DNAdam↑,

324-

AgNPs,

CPT,

Silver Nanoparticles Potentiates Cytotoxicity and Apoptotic Potential of Camptothecin in Human Cervical Cancer Cells

-

in-vitro,

Cerv,

HeLa

ROS↑, Casp3↑, Casp9↑, Casp6↑, GSH↓, SOD↓, GPx↓, MMP↓, P53↑, P21↑, Cyt‑c↑, BID↑, BAX↑, Bcl-2↓, Bcl-xL↓, Akt↓, Raf↓, ERK↓, MAP2K1/MEK1↓, JNK↑, p38↑,

369-

AgNPs,

Silver nanoparticles induce oxidative cell damage in human liver cells through inhibition of reduced glutathione and induction of mitochondria-involved apoptosis

-

in-vitro,

Liver,

NA

ROS↑, GSH↓, DNAdam↑, lipid-P↝, Apoptosis↑, BAX↑, Bcl-2↓, MMP↓, Casp9↑, Casp3↑, JNK↑,

363-

AgNPs,

Silver nanoparticles induce oxidative cell damage in human liver cells through inhibition of reduced glutathione and induction of mitochondria-involved apoptosis

ROS↑, lipid-P↑, Apoptosis↑, BAX↑, Bcl-2↓, MMP↓, Cyt‑c↑, Casp3↑, Casp9↑, JNK↑,

359-

AgNPs,

Anti-cancer & anti-metastasis properties of bioorganic-capped silver nanoparticles fabricated from Juniperus chinensis extract against lung cancer cells

-

in-vitro,

Lung,

A549

 9.87ug/ml

-

in-vitro,

Nor,

HEK293

111.3ug/ml

normal cells

Casp3↑, Casp9↑, P53↑, ROS↑, MMP2↓, MMP9↓, TumCCA↑, *toxicity↓, TumCMig↓, TumCI↓,

346-

AgNPs,

RSQ,

Investigating Silver Nanoparticles and Resiquimod as a Local Melanoma Treatment

-

in-vivo,

Melanoma,

SK-MEL-28

 AgNP (2 mg/kg) and RSQ (25 mg/kg) administration routes used were peri- and intratumora

 mice

-

in-vivo,

Melanoma,

WM35

ROS↑, Ca+2↝, Casp3↑, Casp8↑, Casp9↑, CD4+↑, CD8+↑, tumCV↓, eff↓, *toxicity↓,

350-

AgNPs,

Cytotoxic and Apoptotic Effects of Green Synthesized Silver Nanoparticles via Reactive Oxygen Species-Mediated Mitochondrial Pathway in Human Breast Cancer Cells

-

in-vitro,

BC,

MCF-7

 40ug/mL

ROS↑, MMP↓, P53↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓,

351-

AgNPs,

Study of antitumor activity in breast cell lines using silver nanoparticles produced by yeast

-

in-vitro,

BC,

MCF-7

 5ug/mL

-

in-vitro,

BC,

T47D

Casp9↑, Casp3↑, Casp7↑, Bcl-2↓,

397-

AgNPs,

GEM,

Silver nanoparticles enhance the apoptotic potential of gemcitabine in human ovarian cancer cells: combination therapy for effective cancer treatment

-

in-vitro,

Ovarian,

A2780S

50 nM GEM, 50 nM AgNPs

6nm

P53↑, P21↑, BAX↑, Bak↑, Cyt‑c↑, Casp3↑, Casp9↑, Bcl-2↓, ROS↑, MMP↓,

387-

AgNPs,

Silver nanoparticles induce mitochondria-dependent apoptosis and late non-canonical autophagy in HT-29 colon cancer cells

-

in-vitro,

Colon,

HT-29

33.45 μg/mL

Cyt‑c↑, P53↑, BAX↑, Casp3↑, Casp9↑, Casp12↑, Beclin-1↑, CHOP↑, LC3s↑, XBP-1↑,

384-

AgNPs,

Dual functions of silver nanoparticles in F9 teratocarcinoma stem cells, a suitable model for evaluating cytotoxicity- and differentiation-mediated cancer therapy

-

in-vitro,

Testi,

F9

LDH↓, ROS↑, mtDam↑, DNAdam↑, P53↑, P21↑, BAX↑, Casp3↑, Bcl-2↓, Casp9↑, Nanog↓, OCT4↓,

2655-

AL,

Allicin and Digestive System Cancers: From Chemical Structure to Its Therapeutic Opportunities

-

Review,

GC,

NA

TGF-β↓, cycD1/CCND1↓, cycE/CCNE↓, CDK1↓, DNAdam↑, ROS↑, BAX↑, JNK↑, MMP↓, p38↑, MAPK↑, Fas↑, Cyt‑c↑, Casp8↑, PARP↑, Casp3↑, Casp9↑, Ca+2↑, ER Stress↑, P21↑, CDK2↓, CDK6↑, TumCCA↑, CDK4↓,

2660-

AL,

Allicin: A review of its important pharmacological activities

-

Review,

AD,

NA

-

Review,

Var,

NA

-

Review,

Park,

NA

-

Review,

Stroke,

NA

*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2↓, *IL6↓, *TNF-α↓, *MPO↓, *eff↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2↓, p‑FAK↓,

245-

AL,

Allicin: a promising modulator of apoptosis and survival signaling in cancer

-

Review,

Var,

NA

Fas↑, Bcl-2↓, BAX↑, PI3k/Akt/mTOR↝, Casp3↑, Casp8↑, Casp9↑, Apoptosis↓, *toxicity↓, Cyt‑c↑,

251-

AL,

Inhibition of allicin in Eca109 and EC9706 cells via G2/M phase arrest and mitochondrial apoptosis pathway

-

in-vitro,

ESCC,

Eca109

 0-100ug/ml

-

in-vitro,

ESCC,

EC9706

-

in-vivo,

NA,

NA

5mg/kg/bw

mice

Apoptosis↑, P53↑, P21↑, CHK1↑, CycB/CCNB1↓, BAX↑, Casp3↑, Casp9↑, Cyt‑c↑,

241-

AL,

Role of p38 MAPK activation and mitochondrial cytochrome-c release in allicin-induced apoptosis in SK-N-SH cells

-

in-vitro,

neuroblastoma,

SK-N-SH

 5 μmol/l

 (0, 0.5, 1, 5, 10, and 20 Î¼mol/l) of allicin for 12, 24, and 48 h

Casp3↑, Casp9↑, p38↑, MAPK↑, Cyt‑c↑, Apoptosis↑,

239-

AL,

Allicin induces apoptosis in gastric cancer cells through activation of both extrinsic and intrinsic pathways

-

in-vitro,

GC,

SGC-7901

 30ug/ml

Apoptosis↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, BAX↑, Fas↑, tumCV↓, DNAdam↑, ROS↑, Telomerase↓,

234-

AL,

Allicin Induces Anti-human Liver Cancer Cells through the p53 Gene Modulating Apoptosis and Autophagy

-

in-vitro,

HCC,

Hep3B

 0, 15, 20, 25, 35, 40 and 50 Î¼M of allicin for 24 h

 35 uM @24h

ROS↑, *toxicity∅, MMP↓, BAX↑, Bcl-2↓, AIF↑, Casp3↑, Casp8↑, Casp9↑, eff↓, γH2AX↑, selectivity↑, DNA-PK↑,

5168-

AL,

Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells

-

in-vitro,

Var,

NA

TumCG↓, Casp3↑, Casp8↑, Casp9↑, chemoPv↑,

3541-

ALA,

Insights on alpha lipoic and dihydrolipoic acids as promising scavengers of oxidative stress and possible chelators in mercury toxicology

-

Review,

Var,

NA

*antiOx↑, *IronCh↑, *GSH↑, *BBB↑, Apoptosis↑, MMP↓, ROS↑, lipid-P↑, PARP1↑, Casp3↑, Casp9↑, *NRF2↑, *GSH↑, *ROS↓, RenoP↑, ChemoSen↑, *BG↓,

278-

ALA,

The Multifaceted Role of Alpha-Lipoic Acid in Cancer Prevention, Occurrence, and Treatment

-

Review,

NA,

NA

ROS↑, NRF2↑, Inflam↓, frataxin↑, *BioAv↓, ChemoSen↑, Hif1a↓, eff↑, FAK↓, ITGB1↓, MMP2↓, MMP9↓, EMT↓, Snail↓, Vim↓, Zeb1↓, P53↑, MGMT↓, Mcl-1↓, Bcl-xL↓, Bcl-2↓, survivin↓, Casp3↑, Casp9↑, BAX↑, p‑Akt↓, GSK‐3β↓, *antiOx↑, *ROS↓, selectivity↑, angioG↓, MMPs↓, NF-kB↓, ITGB3↓, NADPH↓,

281-

ALA,

Reactive oxygen species mediate caspase activation and apoptosis induced by lipoic acid in human lung epithelial cancer cells through Bcl-2 down-regulation

-

in-vitro,

Lung,

H460

0-100uM

mt-ROS↑, Apoptosis↑, Casp9↑, Bcl-2↓, eff↓, eff↑, H2O2↑, Dose↑,

267-

ALA,

α-Lipoic Acid Targeting PDK1/NRF2 Axis Contributes to the Apoptosis Effect of Lung Cancer Cells

-

vitro+vivo,

Lung,

A549

 1.5 mM LA for 24 h

-

vitro+vivo,

Lung,

PC9

Apoptosis↑, ROS↑, PDK1↓, NRF2↓, PDK1↓, Bcl-2↓, Casp9↑, Dose∅,

1078-

And,

Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway

-

in-vitro,

BC,

MDA-MB-231

5, 10, 25 and 50 μM

20uM

-

in-vitro,

Nor,

HUVECs

50uM

-

in-vivo,

BC,

MCF-7

35uM

xenografts nude mice

-

in-vitro,

BC,

T47D

32uM

-

in-vitro,

BC,

BT549

23uM

-

in-vitro,

BC,

MDA-MB-361

31uM

TumCP↓, COX2↓, *angioG↓, Cyt‑c↑, CREB2↓, cFos↓, NF-kB↓, HATs↓, cl‑Casp3↑, cl‑Casp9↑, Bax:Bcl2↑, Apoptosis↑, *toxicity↓,

1009-

And,

5-FU,

Andrographis-mediated chemosensitization through activation of ferroptosis and suppression of β-catenin/Wnt-signaling pathways in colorectal cancer

-

in-vivo,

CRC,

HCT116

-

in-vitro,

CRC,

SW480

ChemoSen↑, Casp9↑, Ferroptosis↑, Wnt/(β-catenin)↓, FTL↑, TP53↑, ACSL5↑, GCLC↑, GCLM↑, SAT1↑, STEAP3↑, ACSL5↑,

1563-

Api,

MET,

Metformin-induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells

-

in-vitro,

Nor,

HDFa

metformin (5 mM), apigenin (1 or 20 µM),

-

in-vitro,

PC,

AsPC-1

-

in-vitro,

PC,

MIA PaCa-2

-

in-vitro,

Pca,

DU145

-

in-vitro,

Pca,

LNCaP

-

in-vivo,

NA,

NA

mice

selectivity↑, selectivity↑, selectivity↓, ROS↑, eff↑, tumCV↓, MMP↓, Dose∅, eff↓, DNAdam↑, Apoptosis↑, TumAuto↑, Necroptosis↑, p‑P53↑, BIM↑, BAX↑, p‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Bcl-2↓, AIF↑, p62↑, LC3B↑, MLKL↑, p‑MLKL↓, RIP3↑, p‑RIP3↑, TumCG↑, TumW↓,

2632-

Api,

Apigenin inhibits migration and induces apoptosis of human endometrial carcinoma Ishikawa cells via PI3K-AKT-GSK-3β pathway and endoplasmic reticulum stress

-

in-vitro,

EC,

NA

 20–60 μM

45.55 μM

TumCP↓, TumCCA↑, Apoptosis↑, Bcl-2↓, BAX↑, Bak↑, Casp↑, ER Stress↑, Ca+2↑, ATF4↑, CHOP↑, ROS↑, MMP↓, TumCMig↓, TumCI↓, eff↑, P53↑, P21↑, Cyt‑c↑, Casp9↑, Casp3↑, Bcl-xL↓,

2634-

Api,

Apigenin induces both intrinsic and extrinsic pathways of apoptosis in human colon carcinoma HCT-116 cells

-

in-vitro,

CRC,

HCT116

TumCG↓, TumCCA↑, MMP↓, ROS↑, Ca+2↑, ER Stress↑, mtDam↑, CHOP↑, DR5↑, cl‑BID↑, BAX↑, Cyt‑c↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, Apoptosis↑,

2639-

Api,

Plant flavone apigenin: An emerging anticancer agent

-

Review,

Var,

NA

*antiOx↑, *Inflam↓, AntiCan↑, ChemoSen↑, BioEnh↑, chemoPv↑, IL6↓, STAT3↓, NF-kB↓, IL8↓, eff↝, Akt↓, PI3K↓, HER2/EBBR2↓, cycD1/CCND1↓, CycD3↓, p27↑, FOXO3↑, STAT3↓, MMP2↓, MMP9↓, VEGF↓, Twist↓, MMP↓, ROS↑, NADPH↑, NRF2↓, SOD↓, COX2↓, p38↑, Telomerase↓, HDAC↓, HDAC1↓, HDAC3↓, Hif1a↓, angioG↓, uPA↓, Ca+2↑, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Casp12↑, Casp3↑, cl‑PARP↑, E-cadherin↑, β-catenin/ZEB1↓, cMyc↓, CDK4↓, CDK2↓, CDK6↓, IGF-1↓, CK2↓, CSCs↓, FAK↓, Gli↓, GLUT1↓,

2640-

Api,

Apigenin: A Promising Molecule for Cancer Prevention

-

Review,

Var,

NA

chemoPv↑, ITGB4↓, TumCI↓, TumMeta↓, Akt↓, ERK↓, p‑JNK↓, *Inflam↓, *PKCδ↓, *MAPK↓, EGFR↓, CK2↓, TumCCA↑, CDK1↓, P53↓, P21↑, Bax:Bcl2↑, Cyt‑c↑, APAF1↑, Casp↑, cl‑PARP↑, VEGF↓, Hif1a↓, IGF-1↓, IGFBP3↑, E-cadherin↑, β-catenin/ZEB1↓, HSPs↓, Telomerase↓, FASN↓, MMPs↓, HER2/EBBR2↓, CK2↓, eff↑, AntiAg↑, eff↑, FAK↓, ROS↑, Bcl-2↓, Cyt‑c↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑, cl‑IAP2↑, AR↓, PSA↓, p‑pRB↓, p‑GSK‐3β↓, CDK4↓, ChemoSen↑, Ca+2↑, cal2↑,

584-

Api,

Cisplatin,

Apigenin potentiates the antitumor activity of 5-FU on solid Ehrlich carcinoma: Crosstalk between apoptotic and JNK-mediated autophagic cell death platforms

-

in-vivo,

Var,

NA

Eighty Swiss albino male mice

Beclin-1↑, Casp3↑, Casp9↑, JNK↑, Mcl-1↓, Ki-67↓,

310-

Api,

Apigenin inhibits renal cell carcinoma cell proliferation

-

vitro+vivo,

RCC,

ACHN

 5-80 uM

39.4 μM for 24 h; 15.4 μM for 48 h

 5, 10 and 20 uM

-

in-vitro,

RCC,

786-O

 39.1 μM for 24 h; 19.0 μM for 48 h

-

in-vitro,

RCC,

Caki-1

 50.9 μM for 24 h; 21.4 μM for 48 h

-

in-vitro,

RCC,

HK-2

 122.1 μM for 24 h; 70.2 μM for 48 h

TumCCA↑, p‑ATM↑, p‑CHK1↑, p‑CDC25↑, p‑cDC2↑, P53↑, BAX↑, Casp9↑, Casp3↑,

206-

Api,

Inhibition of glutamine utilization sensitizes lung cancer cells to apigenin-induced apoptosis resulting from metabolic and oxidative stress

-

in-vitro,

Lung,

H1299

 20 uM

-

in-vitro,

Lung,

H460

-

in-vitro,

Lung,

A549

 40 uM

-

in-vitro,

CRC,

HCT116

-

in-vitro,

Melanoma,

A375

-

in-vitro,

Lung,

H2030

-

in-vitro,

CRC,

SW480

Glycolysis↓, lactateProd↓, PGK1↓, ALDOA↓, GLUT1↓, ENO1↓, ATP↓, Casp9↑, Casp3↑, cl‑PARP↑, PI3K/Akt↓, HK1↓, HK2↓, ROS↑, Apoptosis↑, eff↓, NADPH↓, PPP↓,

270-

Api,

Apigenin induces apoptosis in human leukemia cells and exhibits anti-leukemic activity in vivo via inactivation of Akt and activation of JNK

-

in-vivo,

AML,

U937

 20-40 uM (12/24h)

Akt↓, JNK↑, Mcl-1↓, cl‑Bcl-2↓, Casp3↑, Casp7↑, Casp9↑, cl‑PARP↑, mTOR↓, GSK‐3β↓,

416-

Api,

In Vitro and In Vivo Anti-tumoral Effects of the Flavonoid Apigenin in Malignant Mesothelioma

-

vitro+vivo,

NA,

NA

20 mg/kg (C57BL/6 mice, oral gavage)

Malignant mesothelioma (MM)

Bax:Bcl2↑, P53↑, ROS↑, Casp9↑, Casp8↑, cl‑PARP1↑, p‑ERK⇅, p‑JNK↓, p‑p38↑, p‑Akt↓, cJun↓, NF-kB↓, EGFR↓, TumCCA↑,

3391-

ART/DHA,

Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug

-

Review,

Var,

NA

TumCP↓, TumMeta↓, angioG↓, TumVol↓, BioAv↓, Half-Life↓, BioAv↑, eff↑, eff↓, ROS↑, selectivity↑, TumCCA↑, survivin↓, BAX↑, Casp3↓, Casp8↑, Casp9↑, CDC25↓, CycB/CCNB1↓, NF-kB↓, cycD1/CCND1↓, cycE/CCNE↓, E2Fs↓, P21↑, p27↑, ADP:ATP↑, MDM2↓, VEGF↓, IL8↓, COX2↓, MMP9↓, ER Stress↓, cMyc↓, GRP78/BiP↑, DNAdam↑, AP-1↓, MMP2↓, PKCδ↓, Raf↓, ERK↓, JNK↓, PCNA↓, CDK2↓, CDK4↓, TOP2↓, uPA↓, MMP7↓, TIMP2↑, Cdc42↑, E-cadherin↑,

5133-

ART/DHA,

Dihydroartemisinin Exerts Anti-Tumor Activity by Inducing Mitochondrion and Endoplasmic Reticulum Apoptosis and Autophagic Cell Death in Human Glioblastoma Cells

-

in-vitro,

GBM,

U87MG

-

in-vitro,

GBM,

U251

AntiTum↑, tumCV↓, Apoptosis↓, MMP↓, Cyt‑c↑, Casp9↑, CHOP↑, GRP78/BiP↑, eIF2α↑, Casp12↑, ER Stress↑, TumAuto↑, ROS↑,

566-

ART/DHA,

2DG,

Dihydroartemisinin inhibits glucose uptake and cooperates with glycolysis inhibitor to induce apoptosis in non-small cell lung carcinoma cells

-

in-vitro,

Lung,

A549

-

in-vitro,

Lung,

PC9

GlucoseCon↓, ATP↓, lactateProd↓, p‑S6↓, mTOR↓, GLUT1↓, Casp9↑, Casp8↑, Casp3↑, Cyt‑c↑, AIF↑, ROS↑,

1079-

ART/DHA,

Artesunate inhibits the growth and induces apoptosis of human gastric cancer cells by downregulating COX-2

-

in-vitro,

GC,

BGC-823

 20 mg/L

 20 mg/L @ 60hr

-

in-vitro,

GC,

HGC27

-

in-vitro,

GC,

MGC803

TumCP↓, Apoptosis↑, COX2↓, BAX↑, Bcl-2↓, Casp3↑, Casp9↑, MMP↓,

2576-

ART/DHA,

AL,

The Synergistic Anticancer Effect of Artesunate Combined with Allicin in Osteosarcoma Cell Line in Vitro and in Vivo

-

in-vitro,

OS,

MG63

-

in-vivo,

NA,

NA

0 mg/kg per
day, i.p.), allicin (5 mg/kg per day, i.p.)

mice

eff↑, tumCV↓, Casp3↑, Casp9↑, Apoptosis↑, TumCG↓,

3160-

Ash,

Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal

-

Review,

Var,

NA

TumCCA↑, H3↑, P21↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDC2↓, CHK1↓, Chk2↓, p38↑, MAPK↑, E6↓, E7↓, P53↑, Akt↓, FOXO3↑, ROS↑, γH2AX↑, MMP↓, mitResp↓, eff↑, TumCD↑, Mcl-1↓, ER Stress↑, ATF4↑, ATF3↑, CHOP↑, NOTCH↓, NF-kB↓, Bcl-2↓, STAT3↓, CDK1↓, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, Cyt‑c↑, eff↑, CDK4↓, p‑RB1↓, PARP↑, cl‑Casp3↑, cl‑Casp9↑, NRF2↑, ER-α36↓, LDHA↓, lipid-P↑, AP-1↓, COX2↓, RenoP↑, PDGFR-BB↓, SIRT3↑, MMP2↓, MMP9↓, NADPH↑, NQO1↑, GSR↑, HO-1↑, *SOD2↑, *Prx↑, *Casp3?, eff↑, Snail↓, Slug↓, Vim↓, CSCs↓, HEY1↓, MMPs↓, VEGF↓, uPA↓, *toxicity↓, CDK2↓, CDK4↓, HSP90↓,

1369-

Ash,

Withaferin A inhibits cell proliferation of U266B1 and IM-9 human myeloma cells by inducing intrinsic apoptosis

-

in-vitro,

Melanoma,

U266

9 μM

tumCV↓, Apoptosis↑, BAX↑, Cyt‑c↑, Bcl-2↓, cl‑PARP↑, cl‑Casp3↑, cl‑Casp9↑, ROS↑, eff↓,

1371-

Ash,

Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic cell death of human myeloid leukemia HL-60 cells by a dietary compound withaferin A with concomitant protection by N-acetyl cysteine

-

in-vitro,

AML,

HL-60

ROS↑, MMP↓, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, eff↓,

1364-

Ash,

Withaferin a Triggers Apoptosis and DNA Damage in Bladder Cancer J82 Cells through Oxidative Stress

-

in-vitro,

Bladder,

J82

cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, ROS↑, MMP↓, DNAdam↑, eff↓,

Showing Research Papers: 1 to 50 of 321
Page 1 of 7 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 321

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

ATF3↑, 1, Ferroptosis↑, 1, frataxin↑, 1, GCLC↑, 1, GCLM↑, 1, GPx↓, 1, GPx4↓, 1, GSH↓, 3, GSR↑, 1, H2O2↑, 1, HK1↓, 1, HO-1↑, 1, lipid-P↑, 3, lipid-P↝, 1, NQO1↑, 1, NRF2↓, 2, NRF2↑, 3, ROS↑, 31, mt-ROS↑, 1, SIRT3↑, 1, SOD↓, 2, xCT↓, 1,

Metal & Cofactor Biology ⓘ

FTL↑, 1, STEAP3↑, 1,

Mitochondria & Bioenergetics ⓘ

ADP:ATP↑, 1, AIF↑, 3, ATP↓, 2, CDC2↓, 1, CDC25↓, 1, p‑CDC25↑, 1, mitResp↓, 1, MMP↓, 18, mtDam↑, 3, Raf↓, 2, XIAP↓, 1,

Core Metabolism/Glycolysis ⓘ

ACSL5↑, 2, ALDOA↓, 1, AMPK↑, 1, cMyc↓, 2, ENO1↓, 1, FASN↓, 1, GlucoseCon↓, 1, Glycolysis↓, 1, HK2↓, 1, lactateProd↓, 2, LDH↓, 2, LDHA↓, 1, NADPH↓, 2, NADPH↑, 2, PDK1↓, 2, PGK1↓, 1, PI3K/Akt↓, 1, PI3k/Akt/mTOR↝, 1, PPP↓, 1, p‑S6↓, 1, SAT1↑, 1, SIRT1↓, 1, SREBP1↓, 1,

Cell Death ⓘ

Akt↓, 6, p‑Akt↓, 2, APAF1↑, 1, Apoptosis↓, 2, Apoptosis↑, 21, Bak↑, 2, BAX↑, 24, Bax:Bcl2↑, 6, Bcl-2↓, 22, Bcl-2↑, 1, cl‑Bcl-2↓, 1, Bcl-xL↓, 3, BID↑, 1, cl‑BID↑, 1, BIM↑, 1, Casp↑, 2, Casp12↑, 4, Casp3↓, 1, Casp3↑, 36, cl‑Casp3↑, 7, Casp6↑, 1, Casp7↑, 3, cl‑Casp7↑, 1, Casp8↑, 12, cl‑Casp8↑, 3, Casp9↑, 43, cl‑Casp9↑, 7, Chk2↓, 1, CK2↓, 3, Cyt‑c↑, 22, DR5↑, 1, Fas↑, 5, Ferroptosis↑, 1, HEY1↓, 1, cl‑IAP2↑, 1, JNK↓, 2, JNK↑, 6, p‑JNK↓, 2, MAPK↑, 3, Mcl-1↓, 5, MDM2↓, 1, MLKL↑, 1, p‑MLKL↓, 1, Necroptosis↑, 1, p27↑, 2, p38↑, 6, p‑p38↑, 1, survivin↓, 2, Telomerase↓, 3, TumCD↑, 1,

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 2,

Transcription & Epigenetics ⓘ

cJun↓, 1, H3↑, 1, HATs↓, 1, p‑pRB↓, 1, tumCV↓, 6,

Protein Folding & ER Stress ⓘ

ATF6↑, 1, CHOP↑, 6, eIF2α↑, 1, ER Stress↓, 1, ER Stress↑, 6, GRP78/BiP↑, 2, HSP90↓, 1, HSPs↓, 1, IRE1↑, 1, PERK↑, 1, UPR↑, 1, XBP-1↑, 1,

Autophagy & Lysosomes ⓘ

Beclin-1↑, 3, LC3B↑, 1, LC3s↑, 1, p62↑, 1, TumAuto↑, 4,

DNA Damage & Repair ⓘ

p‑ATM↑, 1, CHK1↓, 2, CHK1↑, 1, p‑CHK1↑, 1, DNA-PK↑, 1, DNAdam↑, 10, MGMT↓, 1, P53↓, 1, P53↑, 16, p‑P53↑, 1, PARP↑, 2, PARP↝, 1, p‑PARP↑, 1, cl‑PARP↑, 7, PARP1↑, 1, cl‑PARP1↑, 1, PCNA↓, 1, TP53↑, 1, γH2AX↑, 2,

Cell Cycle & Senescence ⓘ

CDK1↓, 3, CDK2↓, 4, CDK4↓, 6, cycA1/CCNA1↓, 1, CycB/CCNB1↓, 4, cycD1/CCND1↓, 3, CycD3↓, 1, cycE/CCNE↓, 3, E2Fs↓, 1, P21↑, 12, p‑RB1↓, 1, TumCCA↑, 13,

Proliferation, Differentiation & Cell State ⓘ

CD133↓, 1, CD44↓, 1, p‑cDC2↑, 1, cFos↓, 1, CREB2↓, 1, CSCs↓, 3, EMT↓, 3, ERK↓, 3, p‑ERK⇅, 1, FOXO3↑, 2, Gli↓, 1, GSK‐3β↓, 2, p‑GSK‐3β↓, 1, HDAC↓, 1, HDAC1↓, 1, HDAC3↓, 1, IGF-1↓, 2, IGFBP3↑, 1, MAP2K1/MEK1↓, 1, mTOR↓, 3, Nanog↓, 1, NOTCH↓, 1, NOTCH1↓, 1, NOTCH3↓, 1, OCT4↓, 1, PI3K↓, 2, STAT3↓, 4, TOP2↓, 1, TumCG↓, 5, TumCG↑, 1, Wnt↓, 1, Wnt/(β-catenin)↓, 1,

Migration ⓘ

AntiAg↑, 1, AP-1↓, 2, Ca+2↑, 5, Ca+2↝, 1, cal2↑, 1, Cdc42↑, 1, E-cadherin↑, 3, ER-α36↓, 1, FAK↓, 3, p‑FAK↓, 1, ITGB1↓, 1, ITGB3↓, 1, ITGB4↓, 1, Ki-67↓, 1, miR-133a-3p↑, 1, MMP2↓, 5, MMP7↓, 1, MMP9↓, 6, MMPs↓, 3, N-cadherin↓, 1, PKCδ↓, 1, RIP3↑, 1, p‑RIP3↑, 1, Slug↓, 1, Snail↓, 2, TGF-β↓, 1, TIMP2↑, 1, TumCI↓, 4, TumCMig↓, 3, TumCP↓, 6, TumMeta↓, 3, Twist↓, 1, uPA↓, 3, Vim↓, 3, Zeb1↓, 1, β-catenin/ZEB1↓, 4,

Angiogenesis & Vasculature ⓘ

angioG↓, 3, ATF4↑, 3, EGFR↓, 3, EPR↑, 1, Hif1a↓, 4, PDGFR-BB↓, 1, VEGF↓, 6, VEGFR2↓, 1,

Barriers & Transport ⓘ

GLUT1↓, 3, P-gp↓, 1,

Immune & Inflammatory Signaling ⓘ

CD4+↑, 1, COX2↓, 5, IL6↓, 1, IL8↓, 3, Imm↑, 1, Inflam↓, 1, NF-kB↓, 8, PSA↓, 1, TNF-α↑, 1,

Hormonal & Nuclear Receptors ⓘ

AR↓, 1, CDK6↓, 1, CDK6↑, 1,

Drug Metabolism & Resistance ⓘ

BioAv↓, 1, BioAv↑, 1, BioEnh↑, 1, ChemoSen↑, 6, Dose↑, 1, Dose∅, 2, eff↓, 9, eff↑, 13, eff↝, 1, Half-Life↓, 1, selectivity↓, 1, selectivity↑, 6,

Clinical Biomarkers ⓘ

AR↓, 1, E6↓, 1, E7↓, 1, EGFR↓, 3, HER2/EBBR2↓, 2, IL6↓, 1, Ki-67↓, 1, LDH↓, 2, PSA↓, 1, TP53↑, 1,

Functional Outcomes ⓘ

AntiCan↑, 2, AntiTum↑, 3, chemoP↑, 1, chemoPv↑, 3, QoL↑, 1, RenoP↑, 2, TumVol↓, 1, TumW↓, 1,

Infection & Microbiome ⓘ

Bacteria↓, 1, CD8+↑, 1,
Total Targets: 284

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

antiOx↑, 5, GSH↑, 3, GSTs↑, 1, Keap1↓, 1, lipid-P↓, 1, MDA↓, 1, MPO↓, 1, NRF2↑, 2, Prx↑, 1, ROS↓, 4, SOD↑, 1, SOD2↑, 1, TBARS↓, 1,

Metal & Cofactor Biology ⓘ

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1, H2S↑, 1, LDH↓, 2,

Cell Death ⓘ

Akt↓, 1, Casp3?, 1, iNOS↓, 1, MAPK↓, 1,

Transcription & Epigenetics ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

angioG↓, 1, NO↓, 1,

Barriers & Transport ⓘ

Immune & Inflammatory Signaling ⓘ

COX2↓, 1, IL6↓, 1, Inflam↓, 3, NF-kB↓, 1, PGE2↓, 1, TNF-α↓, 1,

Drug Metabolism & Resistance ⓘ

BioAv↓, 1, eff↑, 1, Half-Life↝, 1,

Clinical Biomarkers ⓘ

ALAT↓, 1, AST↓, 1, BG↓, 1, BP↓, 1, creat↓, 1, GutMicro↑, 1, IL6↓, 1, LDH↓, 2,

Functional Outcomes ⓘ

cardioP↑, 1, cognitive↑, 1, hepatoP↑, 1, memory↑, 1, neuroP↑, 2, toxicity↓, 5, toxicity∅, 1,
Total Targets: 51

Scientific Paper Hit Count for: Casp9, Caspase-9

20 Quercetin
17 Silver-NanoParticles
15 Baicalein
13 Curcumin
13 Thymoquinone
12 Sulforaphane (mainly Broccoli)
11 Fisetin
10 Apigenin (mainly Parsley)
9 Allicin (mainly Garlic)
9 Berberine
9 Betulinic acid
9 Emodin
8 Silymarin (Milk Thistle) silibinin
7 Luteolin
6 Artemisinin
6 Chrysin
6 Citric Acid
6 EGCG (Epigallocatechin Gallate)
6 Garcinol
6 Graviola
6 Honokiol
6 Magnolol
5 Gambogic Acid
5 Phenethyl isothiocyanate
5 Shikonin
4 Cisplatin
4 Alpha-Lipoic-Acid
4 Ashwagandha(Withaferin A)
4 Bromelain
4 Capsaicin
4 Carvacrol
4 Photodynamic Therapy
4 Magnetic Fields
4 Plumbagin
4 Resveratrol
3 Berbamine
3 Boron
3 Boswellia (frankincense)
3 Carnosic acid
3 Juglone
3 Propolis -bee glue
3 Piperlongumine
3 Selenium NanoParticles
3 Aflavin-3,3′-digallate
2 Astragalus
2 Andrographis
2 5-fluorouracil
2 Aloe anthraquinones
2 Brucea javanica
2 Thymol-Thymus vulgaris
2 Chlorogenic acid
2 Radiotherapy/Radiation
2 Electrical Pulses
2 Paclitaxel
2 HydroxyTyrosol
2 Lycopene
2 Oleuropein
2 salinomycin
2 Selenium
2 chitosan
2 Selenite (Sodium)
2 Ursolic acid
1 entinostat
1 Camptothecin
1 Resiquimod
1 Gemcitabine (Gemzar)
1 Metformin
1 2-DeoxyGlucose
1 almonertinib
1 epirubicin
1 Biochanin A
1 Bufalin/Huachansu
1 brusatol
1 borneol
1 Caffeic acid
1 Sorafenib (brand name Nexavar)
1 Celecoxib
1 Celastrol
1 Chlorophyllin
1 Deguelin
1 diet Methionine-Restricted Diet
1 Ellagic acid
1 Fucoidan
1 Ferulic acid
1 Hydroxycinnamic-acid
1 Baicalin
1 Melatonin
1 Chemotherapy
1 Magnetic Field Rotating
1 sericin
1 Propyl gallate
1 doxorubicin
1 Sanguinarine
1 polyethylene glycol
1 Auranofin
1 Urolithin
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
1 Vitamin K2
1 VitK3,menadione

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:45  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

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