Catalase Cancer Research Results

Catalase, Catalase: Click to Expand ⟱
Source:
Type:
Caspases are a cysteine protease that speed up a chemical reaction via pointing their target substrates following an aspartic acid residue.1 They are grouped into apoptotic (caspase-2, 3, 6, 7, 8, 9 and 10) and inflammatory (caspase-1, 4, 5, 11 and 12) mediated caspases.
Caspase-1 may have both tumorigenic or antitumorigenic effects on cancer development and progression, but it depends on the type of inflammasome, methodology, and cancer.
Catalase is an enzyme found in nearly all living cells exposed to oxygen. Its primary role is to protect cells from oxidative damage by catalyzing the conversion of hydrogen peroxide (H₂O₂), a potentially damaging byproduct of metabolism, into water (H₂O) and oxygen (O₂). This detoxification process is crucial because excess H₂O₂ can lead to the formation of reactive oxygen species (ROS) that damage proteins, lipids, and DNA.

Catalase and Cancer
Oxidative Stress and Cancer:
Cancer cells often experience increased levels of oxidative stress due to rapid proliferation and metabolic changes. This stress can lead to DNA damage, promoting tumorigenesis.
Catalase helps mitigate oxidative stress, and its expression can influence the survival and proliferation of cancer cells.
Expression Levels in Different Cancers:
Overexpression: In some cancers, such as breast cancer and certain types of leukemia, catalase may be overexpressed. This overexpression can help cancer cells survive in oxidative environments, potentially leading to more aggressive tumor behavior.
Downregulation: Conversely, in other cancers, such as colorectal cancer, reduced catalase expression has been observed. This downregulation can lead to increased oxidative stress, contributing to tumor progression and metastasis.
Prognostic Implications:
Survival Rates: Studies have shown that high levels of catalase expression can be associated with poor prognosis in certain cancers, as it may enable cancer cells to resist apoptosis (programmed cell death) induced by oxidative stress.

Some types of cancer cells have been reported to exhibit lower catalase activity, possibly increasing their vulnerability to oxidative damage under certain conditions. This vulnerability has even been exploited in some therapeutic strategies (for example, approaches that generate excess H₂O₂ or other ROS specifically targeting cancer cells have been researched).
Scientific Papers found: Click to Expand⟱
3453- 5-ALA,    The heme precursor 5-aminolevulinic acid disrupts the Warburg effect in tumor cells and induces caspase-dependent apoptosis
- in-vitro, Lung, A549
OXPHOS↑, OCR↑, Warburg↓, ROS↑, SOD2↑, Catalase↑, HO-1↑, Casp3↑, Apoptosis↑,
1406- AgNPs,    The antioxidant effects of silver, gold, and zinc oxide nanoparticles on male mice in in vivo condition
- in-vivo, Nor, NA
*ROS↓, *GPx↑, *Catalase↑, *ROS↑,
4385- AgNPs,    Hepatoprotective effect of engineered silver nanoparticles coated bioactive compounds against diethylnitrosamine induced hepatocarcinogenesis in experimental mice
- in-vitro, Liver, NA
hepatoP↑, *AST↓, *ALAT↓, *Catalase↑, *GPx↑, *GSTA1↑, *SOD↑,
356- AgNPs,  MF,    Anticancer and antibacterial potentials induced post short-term exposure to electromagnetic field and silver nanoparticles and related pathological and genetic alterations: in vitro study
- in-vitro, BC, MCF-7 - in-vitro, Bladder, HTB-22
Apoptosis↑, P53↑, iNOS↑, NF-kB↑, Bcl-2↓, ROS↑, SOD↑, TumCCA↑, eff↑, Catalase↑, other↑,
2206- AgNPs,  RES,    ENHANCED EFFICACY OF RESVERATROL-LOADED SILVER NANOPARTICLE IN ATTENUATING SEPSIS-INDUCED ACUTE LIVER INJURY: MODULATION OF INFLAMMATION, OXIDATIVE STRESS, AND SIRT1 ACTIVATION
- in-vivo, Nor, NA
*hepatoP↑, *Inflam↓, *NF-kB↓, *VEGF↓, *SIRT1↑, *ROS↓, *Dose↝, *Catalase↑, *MDA↓, *MPO↓, *NO↓, *ALAT↓, *AST↓, *antiOx↑,
2205- AgNPs,    Potential protective efficacy of biogenic silver nanoparticles synthesised from earthworm extract in a septic mice model
- in-vivo, Nor, NA
*Dose↝, *eff↑, *RenoP↑, *antiOx↑, *MDA↓, *NO↓, *hepatoP↑, *toxicity↝, *GSH↑, *SOD↑, *GSTs↑, *Catalase↑,
2558- AL,    Allicin, an Antioxidant and Neuroprotective Agent, Ameliorates Cognitive Impairment
- Review, AD, NA
*AntiCan↑, *antiOx↑, *cardioP↑, *neuroP↑, cognitive↑, *ROS↓, *NOX↓, *TLR4↓, *NF-kB↓, *JNK↓, *AntiAg↑, *H2S↑, *BP↓, Telomerase↓, *Insulin↑, BioAv↝, *GSH↑, *Catalase↑,
3269- ALA,    Sulfur-containing therapeutics in the treatment of Alzheimer’s disease
- NA, AD, NA
*AChE↓, *GlucoseCon↑, *ACC↑, *GSH↑, *Aβ↓, *Catalase↑, *GSR↑, *GSTs↑, *NADPH↑, *NQO1↑, *iNOS↓, *NF-kB↓, *lipid-P↓, *BBB↑, *memory↑, *cognitive↑, *antiOx↑, *Inflam↓,
3439- ALA,    The effect of alpha lipoic acid on the developmental competence of mouse isolated preantral follicles
- in-vitro, NA, NA
*ROS↓, *TAC↑, *eff↑, *SOD↑, *GPx↑, *Catalase↑, *GlucoseCon↑, *antiOx↑,
3547- ALA,    Potential Therapeutic Effects of Lipoic Acid on Memory Deficits Related to Aging and Neurodegeneration
- Review, AD, NA - Review, Park, NA
*memory↑, *neuroP↑, *motorD↑, *VitC↑, *VitE↑, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *5HT↑, *lipid-P↓, *IronCh↑, *AChE↓, *Inflam↓, *GlucoseCon↑, *GLUT3↑, *GLUT4↑, NF-kB↓, *IGF-1↑, *IL1β↓, *TNF-α↓, *cognitive↑, *ChAT↑, *HO-1↑, *NQO1↑,
3545- ALA,    Potential therapeutic effects of alpha lipoic acid in memory disorders
- Review, AD, NA
*neuroP↑, *Inflam↓, *VCAM-1↓, *5HT↑, *memory↑, *BioAv↝, *Half-Life↓, *NF-kB↓, *antiOx↑, *IronCh↑, *ROS↓, *ATP↑, *ChAT↑, *Ach↑, *cognitive↑, *lipid-P↓, *VitC↑, *VitE↑, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *Aβ↓,
4280- Api,    Protective effects of apigenin in neurodegeneration: An update on the potential mechanisms
- Review, AD, NA - Review, Park, NA
*neuroP↑, *antiOx↑, *ROS↓, *Inflam↓, *TNF-α↓, *IL1β↓, *PI3K↑, *Akt↑, *BBB↑, *NRF2↑, *SOD↑, *GPx↑, *MAPK↓, *Catalase↑, *HO-1↑, *COX2↓, *PGE2↓, *PPARγ↑, *TLR4↓, *GSK‐3β↓, *Aβ↓, *NLRP3↓, *BDNF↑, *TrkB↑, *GABA↑, *AChE↓, *Ach↑, *5HT↑, *cognitive↑, *MAOA↓,
1562- Api,    Apigenin protects human melanocytes against oxidative damage by activation of the Nrf2 pathway
- in-vitro, Vit, NA
*SOD↑, *Catalase↑, *GPx↑, *MDA↓, *NRF2↑, *toxicity∅,
2638- Api,    Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death
- in-vitro, lymphoma, PEL
TumCD↑, TumAuto↑, ROS↓, P53↑, Catalase↑, STAT3↓,
3385- ART/DHA,    Interaction of artemisinin protects the activity of antioxidant enzyme catalase: A biophysical study
- Study, NA, NA
*NF-kB↑, *Catalase↑,
3163- Ash,  Rad,    Withaferin A, a steroidal lactone, selectively protects normal lymphocytes against ionizing radiation induced apoptosis and genotoxicity via activation of ERK/Nrf-2/HO-1 axis
*radioP↑, selectivity↑, *Casp3↓, *DNAdam↓, *ROS↓, *GSH↓, *NRF2↑, *HO-1↑, *Catalase↑, *SOD↑, *Prx↑, *ERK↑,
4303- Ash,    Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review
- Review, AD, NA
*neuroP↑, *Sleep↑, *Inflam↓, *cardioP↑, *cognitive↑, *Aβ↓, *TNF-α↓, *IL1β↓, *IL6↓, *MCP1↓, *lipid-P↓, *tau↓, *ROS↓, *BBB↑, *AChE↓, *GSH↑, *GSTs↑, *GSR↑, *GPx↑, *SOD↑, *Catalase↑, ChemoSen↑, *Strength↑,
5384- AsP,  MEL,    Synergistic Anticancer Effect of Melatonin and Ascorbyl Palmitate Nanoformulation: A Promising Combination for Cancer Therapy
- in-vivo, Var, NA
AntiCan↑, TumCG↓, Apoptosis↑, DNAdam↑, TumCCA↑, IL6↓, STAT3↓, TumCP↓, Ki-67↓, TumCI↓, TumMeta↓, MMP9↓, eff↑, *Catalase↑, *SOD↑, *GSH↑, *MDA↓, *NO↓, *antiOx↑, *hepatoP↑, *RenoP↑,
1146- AsP,    Potential use of nanoformulated ascorbyl palmitate as a promising anticancer agent: First comparative assessment between nano and free forms
- in-vivo, Nor, NA
TumCCA↑, Apoptosis↑, IL6↓, STAT3↓, angioG↓, TumMeta↓, VEGF↓, MMP9↓, SOD↑, Catalase↑, GSH↓, MDA↓, NO↓, *BioAv↑,
4806- ASTX,    Astaxanthin's Impact on Colorectal Cancer: Examining Apoptosis, Antioxidant Enzymes, and Gene Expression
- in-vitro, CRC, HCT116
BAX↑, Casp3↑, Apoptosis↑, Bcl-2↓, MDA↓, ROS↓, SOD↑, Catalase↑, GPx↑, antiOx↑, TumCG↓, TumCP↓,
5365- AV,    Aloe Vera Polysaccharides as Therapeutic Agents: Benefits Versus Side Effects in Biomedical Applications
- Review, Nor, NA - Review, IBD, NA - Review, Diabetic, NA
*Wound Healing↑, *Imm↑, *antiOx↑, *AntiDiabetic↑, *AntiCan↑, *Inflam↓, *NF-kB↓, *COX2↓, *5LO↓, *IL1β↓, *IL6↓, *TNF-α↓, *IL10↑, *other↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *DNAdam↓, *GutMicro↑, *ZO-1↑, AntiTum↑, Casp3↑, Casp9↑, angioG↓, MMPs↓, VEGF↓, NK cell↑,
2613- Ba,    Hepatoprotective Effect of Baicalein Against Acetaminophen-Induced Acute Liver Injury in Mice
- in-vivo, Nor, NA
*hepatoP↑, *MDA↓, *SOD↑, *Catalase↑, *GSH↑, *MAPK↓, *p‑JAK2↓, *p‑STAT3↓, *ALAT↓, *AST↓, *ROS↓, *antiOx↑,
2294- Ba,    Baicalein attenuates cardiac hypertrophy in mice via suppressing oxidative stress and activating autophagy in cardiomyocytes
- in-vivo, Nor, NA
*Catalase↑, *ROS↓, *cardioP↑, *FOXO3?,
2674- BBR,    Berberine: A novel therapeutic strategy for cancer
- Review, Var, NA - Review, IBD, NA
Inflam↓, AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, TumCI↓, eff↑, eff↑, CD4+↓, TNF-α↓, IL1↓, BioAv↓, BioAv↓, other↓, AMPK↑, MAPK↓, NF-kB↓, IL6↓, MCP1↓, PGE2↓, COX2↓, *ROS↓, *antiOx↑, *GPx↑, *Catalase↑, AntiTum↑, TumCP↓, angioG↓, Fas↑, FasL↑, ROS↑, ATM↑, P53↑, RB1↑, Casp9↑, Casp8↑, Casp3↓, BAX↑, Bcl-2↓, Bcl-xL↓, IAP1↓, XIAP↓, survivin↓, MMP2↓, MMP9↓, CycB/CCNB1↓, CDC25↓, CDC25↓, Cyt‑c↑, MMP↓, RenoP↑, mTOR↓, MDM2↓, LC3II↑, ERK↓, COX2↓, MMP3↓, TGF-β↓, EMT↑, ROCK1↓, FAK↓, RAS↓, Rho↓, NF-kB↓, uPA↓, MMP1↓, MMP13↓, ChemoSen↑,
2677- BBR,    Liposome-Encapsulated Berberine Alleviates Liver Injury in Type 2 Diabetes via Promoting AMPK/mTOR-Mediated Autophagy and Reducing ER Stress: Morphometric and Immunohistochemical Scoring
- in-vivo, Diabetic, NA
*hepatoP↑, *LC3II↑, *Beclin-1↑, *AMPK↑, *mTOR↑, *ER Stress↓, *CHOP↓, *JNK↓, *ROS↓, *Inflam↓, *BG↓, *SOD↑, *GPx↑, *Catalase↑, *IL10↑, *IL6↓, *TNF-α↓, *ALAT↓, *AST↓, *ALP↓,
2725- BetA,    Betulinic acid protects against renal damage by attenuation of oxidative stress and inflammation via Nrf2 signaling pathway in T-2 toxin-induced mice
- in-vivo, Nor, NA
*RenoP↑, *SOD?, *Catalase↑, *GSH↑, *ROS↓, *MDA↓, *IL1β↓, *TNF-α↓, *IL10↓, *IL6↑, *NRF2↑,
2731- BetA,    Betulinic Acid for Glioblastoma Treatment: Reality, Challenges and Perspectives
- Review, GBM, NA - Review, Park, NA - Review, AD, NA
BBB↑, *GSH↑, *Catalase↑, *motorD↑, *neuroP↑, *cognitive↑, *ROS↓, *antiOx↑, *Inflam↓, MMP↓, STAT3↓, NF-kB↓, Sp1/3/4↓, TOP1↓, EMT↓, Hif1a↓, VEGF↓, ChemoSen↑, RadioS↑, BioAv↓,
2760- BetA,    A Review on Preparation of Betulinic Acid and Its Biological Activities
- Review, Var, NA - Review, Stroke, NA
AntiTum↑, Cyt‑c↑, Smad1↑, Sepsis↓, NF-kB↓, ICAM-1↓, MCP1↓, MMP9↓, COX2↓, PGE2↓, ERK↓, p‑Akt↓, *ROS↓, *LDH↓, *hepatoP↑, *SOD↑, *Catalase↑, *GSH↑, *AST↓, *ALAT↓, *RenoP↑, *ROS↓, *α-SMA↓,
2761- BetA,    Betulinic acid increases lifespan and stress resistance via insulin/IGF-1 signaling pathway in Caenorhabditis elegans
- in-vivo, Nor, NA
Insulin↓, IGF-1↓, *SOD↑, *Catalase↑, *GSH↑, *MDA↓, *antiOx?,
3690- BM,    Neurocognitive Effect of Nootropic Drug Brahmi (Bacopa monnieri) in Alzheimer's Disease
- Review, AD, NA
*ROS↓, *5LO↓, *lipid-P↓, *GPx↑, *IronCh↑, *neuroP↑, *AChE↓, *memory↑, *toxicity↓, *SOD↑, *Catalase↑, *cognitive↑, *ChAT↑, *Ach↑, *BP↓,
3517- Bor,  Se,    The protective effects of selenium and boron on cyclophosphamide-induced hepatic oxidative stress, inflammation, and apoptosis in rats
- in-vivo, Nor, NA
*hepatoP↑, *ALAT↓, *AST↓, *ALP↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *IL6↓, *IL10↑, *SOD↑, *Catalase↑, *MDA↓, *GSH↑, *GPx↑, *antiOx↑, *NRF2↑, *Keap1↓,
3516- Bor,    Boron in wound healing: a comprehensive investigation of its diverse mechanisms
- Review, Wounds, NA
*Inflam↓, *antiOx↑, *ROS↓, *angioG↑, *COL1↑, *α-SMA↑, *TGF-β↑, *BMD↑, *hepatoP↑, *TNF-α↑, *HSP70/HSPA5↑, *SOD↑, *Catalase↑, *GSH↑, *MDA↓, *TOS↓, *IL6↓, *JAK2↓, *STAT3↓, *AMPK↑, *lipid-P↓, *VEGF↑, *Half-Life↝,
3510- Bor,    Boron Affects the Development of the Kidney Through Modulation of Apoptosis, Antioxidant Capacity, and Nrf2 Pathway in the African Ostrich Chicks
- in-vivo, Nor, NA
*RenoP↑, *ROS↓, *antiOx↑, *Apoptosis↓, *NRF2↑, *HO-1↑, *MDA↓, *lipid-P↓, *GPx↓, *Catalase↑, *SOD↑, *ALAT↓, *AST↓, *ALP↓,
696- Bor,    Nothing Boring About Boron
- Review, Var, NA
*hs-CRP↓, *TNF-α↓, *SOD↑, *Catalase↑, *GPx↑, *cognitive↑, *memory↑, *Risk↓, *SAM-e↑, *NAD↝, *ATP↝, *Ca+2↝, HDAC↓, TumVol↓, IGF-1↓, PSA↓, Cyc↓, TumCMig↓, *serineP↓, HIF-1↓, *ChemoSideEff↓, *VitD↑, *Mag↑, *eff↑, Risk↓, *Inflam↓, *neuroP↑, *Calcium↑, *BMD↑, *chemoP↑, AntiCan↑, *Dose↑, *Dose↝, *BMPs↑, *testos↑, angioG↓, Apoptosis↑, *selectivity↑, *chemoPv↑,
743- Bor,    Boric Acid (Boron) Attenuates AOM-Induced Colorectal Cancer in Rats by Augmentation of Apoptotic and Antioxidant Mechanisms
- in-vitro, CRC, NA
BAX↑, Bcl-2↓, GPx↑, SOD↑, Catalase↑, MDA↓, TNF-α↓, IL6↓, IL10↑,
729- Bor,    Promising potential of boron compounds against Glioblastoma: In Vitro antioxidant, anti-inflammatory and anticancer studies
- in-vitro, GBM, U87MG - in-vivo, Nor, HaCaT
TOS↑, TumCG↓, MDA↑, SOD↑, Catalase↑, TAC↓, GSH↓, BRAF↑, MAPK↓, PTEN↓, Raf↓, *toxicity↓,
2776- Bos,    Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities
- Review, Var, NA
*5LO↓, *TNF-α↓, *MMP3↓, *COX1↓, *COX2↓, *PGE2↓, *Th2↑, *Catalase↑, *SOD↑, *NO↑, *PGE2↑, *IL1β↓, *IL6↓, *Th1 response↓, *Th2↑, *iNOS↓, *NO↓, *p‑JNK↓, *p38↓, GutMicro↑, p‑Akt↓, GSK‐3β↓, cycD1/CCND1↓, Akt↓, STAT3↓, CSCs↓, AR↓, P21↑, DR5↑, CHOP↑, Casp3↑, Casp8↑, cl‑PARP↑, DNAdam↑, p‑RB1↓, FOXM1↓, TOP2↓, CDC25↓, p‑CDK1↓, p‑ERK↓, MMP9↓, VEGF↓, angioG↓, ROS↑, Cyt‑c↑, AIF↑, Diablo↑, survivin↓, ICAD↓, ChemoSen↑, SOX9↓, ER Stress↑, GRP78/BiP↑, cal2↓, AMPK↓, mTOR↓, ROS↓,
2768- Bos,    Boswellic acids as promising agents for the management of brain diseases
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*neuroP↑, *ROS↓, *cognitive↓, TumCP↓, TumCMig↓, TumMeta↓, angioG↓, Apoptosis↑, *Inflam↓, IL1↓, IL2↓, IL4↓, IL6↓, TNF-α↓, P53↑, Akt↓, NF-kB↓, DNAdam↑, Casp↑, COX2↓, MMP9↓, CXCR4↓, VEGF↓, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑,
5755- CA,    Caffeic Acid as a Promising Natural Feed Additive: Advancing Sustainable Aquaculture
- Review, Nor, NA
*Imm↑, *Inflam↓, *Bacteria↓, *eff↑, *ROS↓, *MDA↓, *Catalase↑, *GSH↑, *TAC↑, *NF-kB↓, *NLRP3↓, *eff↑, *AST↓, *ALAT↓, *SOD↑, *GSTA1↑,
5847- CAP,    An updated review on molecular mechanisms underlying the anticancer effects of capsaicin
- in-vitro, Liver, HepG2
HO-1↑, ROS↑, NRF2↑, *lipid-P↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, *PGE2↓, *COX2↓, *iNOS↓, TumCP↓, TumCCA↑, cycE/CCNE↓, CDK4↓, MMP↓, P53↑, P21↑, BAX↑, SIRT1↑, angioG↓, P-gp↓, ChemoSen↑,
5887- CAR,  TV,    Antitumor Effects of Carvacrol and Thymol: A Systematic Review
- Review, Var, NA
Apoptosis↑, TumCCA↑, TumMeta↓, TumCP↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, eff↑, *Inflam↓, *antiOx↑, AXL↓, MDA↑, Casp3↑, Bcl-2↓, MMP2↓, MMP9↓, p‑JNK↑, BAX↑, MDA↓, TRPM7↓, MMP↓, Cyt‑c↑, Casp↑, cl‑PARP↑, ROS↑, CDK4↓, P21↑, F-actin↓, GSH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, *GSH↑, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, DNAdam↑, AFP↓, VEGF↓, Weight↑, *chemoP↑, ROS↑,
5881- CAR,    Carvacrol—A Natural Phenolic Compound with Antimicrobial Properties
- Review, Nor, NA
*Bacteria↓, *Inflam↓, *SOD↑, *GPx↑, *GSR↑, *Catalase↑, *toxicity↓, *Pain↓, *other↑, *cardioP↑, *RenoP↑, *neuroP↑, *antiOx↑, *AntiDiabetic↑, *hepatoP↑, *Obesity↓, *AntiAg↑, *BioAv↓, BioAv↝, *OS↑, MMP↓, ROS↑, *MDA↓, *lipid-P↓, *COX2↓, *Dose↝,
5888- CAR,    Therapeutic application of carvacrol: A comprehensive review
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Park, NA
*antiOx↑, *AntiCan↑, *AntiDiabetic↑, *cardioP↑, *Obesity↓, *hepatoP↑, *AntiAg↑, *Bacteria↓, *Imm↑, MMP2↓, MMP9↓, Apoptosis↓, MMP↓, ERK↓, PI3K↓, ALAT↓, *ROS↓, *Catalase↑, *SOD↑, *GPx↑, *AST↓, *LDH↓, *necrosis↓, ROS↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, NOTCH↓, IL6↓, chemoP↑, *Pain↓, *neuroP↑, *TRPM7↓, *motorD↑, *NF-kB↓, *COX2↓, *MDA↓,
5909- CAR,    Potential preventive effect of carvacrol against diethylnitrosamine-induced hepatocellular carcinoma in rats
*AST↓, *ALAT↓, *ALP↓, *LDH↓, *SOD↑, *Catalase↑, *GSH↑, *GPx↑, *GSR↑, *hepatoP↑, *lipid-P↓,
5901- CAR,    Neuroprotective role of carvacrol in ischemic brain injury: a systematic review of preclinical evidence and proposed TRPM7 involvement
- Review, Stroke, NA
*neuroP↑, *ROS↓, *MDA↓, *4-HNE↓, *SOD↑, *Catalase↑, *GPx↑, *Apoptosis↓, *cl‑Casp3↓, *TRPM7⇅, *BBB↓, *TRPM7↓,
5894- CAR,    Targeting Gastrointestinal Cancers with Carvacrol: Mechanistic Insights and Therapeutic Potential
- Review, Var, NA
AntiCan↑, Apoptosis↑, Inflam↓, angioG↓, TumMeta↓, selectivity↑, BioAv↑, ChemoSen↑, Dose↝, TumCP↓, hepatoP↑, Casp3↑, Casp9↑, Bcl-2↓, ROS↑, GSH↓, BAX↑, Casp7↑, Casp8↑, Cyt‑c↑, Fas↑, FADD↑, P53↑, Bcl-2↓, TumMeta↓, TumCMig↓, TumCI↓, E-cadherin↑, TIMP2↑, TIMP3↑, N-cadherin↓, ZEB2↓, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, selectivity↑, cl‑PARP↑, ERK↓, p38↑, OS↑, AFP↓, COX2↓, VEGF↓, PCNA↓, Ki-67↓, TNF-α↓, BioAv↓,
5927- CAR,    Neuroprotective Potential and Underlying Pharmacological Mechanism of Carvacrol for Alzheimer’s and Parkinson’s Diseases
- Review, AD, NA - Review, Park, NA
*memory↑, *cognitive↑, *ROS↓, *Inflam↓, *motorD↑, *toxicity↓, *TRPV3↑, *other↓, *antiOx↑, *LDL↓, *COX2↓, *PPARα↑, *NO↓, *AChE↓, *eff↑, *SOD↑, *Catalase↑, *neuroP↑, *BioAv↝, *BBB↑, *BioAv↑,
5925- CAR,    Neuroprotective effects of carvacrol against Alzheimer’s disease and other neurodegenerative diseases: A review
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *AChE↓, *BBB↑, *cardioP↑, *neuroP↑, *memory↑, *TAC↑, *ROS↓, *lipid-P↓, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *cognitive↑, *IL1β↓, *COX2↓, *TNF-α↓, *TLR4↓, *BDNF↑, *PKCδ↑, *5LO↓, *TRPM7↓, *GSH↑, *other↑, *Ferroptosis↓, *GPx4↑,
5952- Cela,    Celastrol attenuates Alzheimer’s disease-mediated learning and memory impairment by inhibiting endoplasmic reticulum stress-induced inflammation and oxidative stress
- in-vivo, AD, NA
*memory↑, *Inflam↓, *ROS↓, *ER Stress↓, *neuroP↑, *Dose↝, *MDA↓, *SOD↑, *Catalase↑, *Aβ↓, BACE↓, LRP1↑, RAGE↓,
2653- Cela,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
chemoPv↑, Catalase↑, ROS↑, HSP90↓, Sp1/3/4↓, AMPK↑, P53↑, JNK↑, ER Stress↑, MMP↓, TumCCA↑, TumAuto↑, Hif1a↑, Akt↑, other↓, Prx↓,

Showing Research Papers: 1 to 50 of 199
Page 1 of 4 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 199

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↑, 8,   GPx↑, 2,   GSH↓, 4,   HO-1↑, 2,   MDA↓, 4,   MDA↑, 2,   NRF2↑, 1,   OXPHOS↑, 1,   Prx↓, 1,   ROS↓, 3,   ROS↑, 11,   SOD↑, 5,   SOD2↑, 1,   TAC↓, 1,   TOS↑, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   CDC25↓, 3,   Insulin↓, 1,   MMP↓, 7,   OCR↑, 1,   Raf↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   AMPK↓, 1,   AMPK↑, 2,   SIRT1↑, 1,   Warburg↓, 1,  

Cell Death ⓘ

Akt↓, 3,   Akt↑, 1,   p‑Akt↓, 2,   Apoptosis↓, 1,   Apoptosis↑, 10,   BAX↑, 6,   Bcl-2↓, 7,   Bcl-xL↓, 1,   Casp↑, 2,   Casp3↓, 1,   Casp3↑, 6,   Casp7↑, 1,   Casp8↑, 3,   Casp9↑, 3,   Cyt‑c↑, 5,   Diablo↑, 1,   DR5↑, 1,   FADD↑, 1,   Fas↑, 2,   FasL↑, 1,   IAP1↓, 1,   ICAD↓, 1,   iNOS↑, 1,   JNK↑, 1,   p‑JNK↑, 1,   MAPK↓, 3,   MDM2↓, 1,   p38↑, 1,   survivin↓, 2,   Telomerase↓, 1,   TumCD↑, 1,  

Kinase & Signal Transduction ⓘ

SOX9↓, 1,   Sp1/3/4↓, 2,  

Transcription & Epigenetics ⓘ

other↓, 2,   other↑, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↑, 2,   GRP78/BiP↑, 1,   HSP90↓, 1,  

Autophagy & Lysosomes ⓘ

LC3II↑, 1,   TumAuto↑, 3,  

DNA Damage & Repair ⓘ

ATM↑, 1,   DNAdam↑, 4,   P53↑, 7,   cl‑PARP↑, 3,   PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

p‑CDK1↓, 1,   CDK4↓, 3,   Cyc↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   P21↑, 3,   RB1↑, 1,   p‑RB1↓, 1,   TumCCA↑, 8,  

Proliferation, Differentiation & Cell State ⓘ

BRAF↑, 1,   CSCs↓, 1,   EMT↓, 1,   EMT↑, 1,   ERK↓, 4,   p‑ERK↓, 1,   FOXM1↓, 1,   GSK‐3β↓, 1,   HDAC↓, 1,   IGF-1↓, 2,   mTOR↓, 3,   NOTCH↓, 1,   PI3K↓, 2,   PTEN↓, 1,   RAS↓, 1,   STAT3↓, 5,   TOP1↓, 1,   TOP2↓, 1,   TRPM7↓, 1,   TumCG↓, 3,  

Migration ⓘ

AXL↓, 1,   cal2↓, 1,   E-cadherin↑, 1,   F-actin↓, 1,   FAK↓, 1,   Ki-67↓, 2,   LRP1↑, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP2↓, 3,   MMP3↓, 1,   MMP9↓, 8,   MMPs↓, 1,   N-cadherin↓, 1,   RAGE↓, 1,   Rho↓, 1,   ROCK1↓, 1,   Smad1↑, 1,   TGF-β↓, 1,   TIMP2↑, 1,   TIMP3↑, 1,   TumCI↓, 3,   TumCMig↓, 3,   TumCP↓, 7,   TumMeta↓, 7,   uPA↓, 1,   ZEB2↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 8,   HIF-1↓, 1,   Hif1a↓, 1,   Hif1a↑, 1,   NO↓, 1,   VEGF↓, 7,  

Barriers & Transport ⓘ

BBB↑, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

CD4+↓, 1,   COX2↓, 5,   CXCR4↓, 1,   ICAM-1↓, 1,   IL1↓, 2,   IL10↑, 1,   IL2↓, 1,   IL4↓, 1,   IL6↓, 6,   Inflam↓, 2,   MCP1↓, 2,   NF-kB↓, 6,   NF-kB↑, 1,   NK cell↑, 1,   PGE2↓, 2,   PSA↓, 1,   TNF-α↓, 4,  

Protein Aggregation ⓘ

BACE↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 4,   BioAv↑, 1,   BioAv↝, 2,   ChemoSen↑, 6,   Dose↝, 1,   eff↑, 5,   RadioS↑, 1,   selectivity↑, 3,  

Clinical Biomarkers ⓘ

AFP↓, 2,   ALAT↓, 1,   AR↓, 1,   BRAF↑, 1,   FOXM1↓, 1,   GutMicro↑, 1,   IL6↓, 6,   Ki-67↓, 2,   PSA↓, 1,   RAGE↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 4,   AntiTum↑, 3,   chemoP↑, 1,   chemoPv↑, 1,   cognitive↑, 1,   hepatoP↑, 2,   OS↑, 1,   RenoP↑, 1,   Risk↓, 1,   TumVol↓, 1,   Weight↑, 1,  

Infection & Microbiome ⓘ

Sepsis↓, 1,  
Total Targets: 188

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

4-HNE↓, 1,   antiOx?, 1,   antiOx↑, 20,   Catalase↑, 42,   Ferroptosis↓, 1,   GPx↓, 1,   GPx↑, 22,   GPx4↑, 1,   GSH↓, 1,   GSH↑, 18,   GSR↑, 7,   GSTA1↑, 2,   GSTs↑, 3,   HO-1↑, 4,   Keap1↓, 1,   lipid-P↓, 14,   MDA↓, 16,   MPO↓, 1,   NQO1↑, 2,   NRF2↑, 8,   Prx↑, 1,   ROS↓, 27,   ROS↑, 1,   SAM-e↑, 1,   SOD?, 1,   SOD↑, 33,   TAC↑, 3,   TOS↓, 1,   VitC↑, 2,   VitE↑, 2,  

Metal & Cofactor Biology ⓘ

IronCh↑, 3,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,   ATP↝, 1,   Insulin↑, 1,  

Core Metabolism/Glycolysis ⓘ

ACC↑, 1,   ALAT↓, 11,   AMPK↑, 2,   GlucoseCon↑, 3,   H2S↑, 1,   LDH↓, 5,   LDL↓, 1,   NAD↝, 1,   NADPH↑, 1,   PPARα↑, 1,   PPARγ↑, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Akt↑, 1,   Apoptosis↓, 2,   Casp3↓, 1,   cl‑Casp3↓, 1,   Ferroptosis↓, 1,   iNOS↓, 3,   JNK↓, 2,   p‑JNK↓, 1,   MAPK↓, 2,   necrosis↓, 1,   p38↓, 1,  

Kinase & Signal Transduction ⓘ

TRPV3↑, 1,  

Transcription & Epigenetics ⓘ

Ach↑, 3,   other↓, 2,   other↑, 2,  

Protein Folding & ER Stress ⓘ

CHOP↓, 1,   ER Stress↓, 2,   HSP70/HSPA5↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   LC3II↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 2,  

Proliferation, Differentiation & Cell State ⓘ

ERK↑, 1,   FOXO3?, 1,   GSK‐3β↓, 1,   IGF-1↑, 1,   mTOR↑, 1,   PI3K↑, 1,   STAT3↓, 1,   p‑STAT3↓, 1,   TRPM7↓, 3,   TRPM7⇅, 1,  

Migration ⓘ

5LO↓, 4,   AntiAg↑, 3,   Ca+2↝, 1,   COL1↑, 1,   MMP3↓, 1,   PKCδ↑, 1,   serineP↓, 1,   TGF-β↑, 1,   VCAM-1↓, 1,   ZO-1↑, 1,   α-SMA↓, 1,   α-SMA↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↑, 1,   NO↓, 5,   NO↑, 1,   VEGF↓, 1,   VEGF↑, 1,  

Barriers & Transport ⓘ

BBB↓, 1,   BBB↑, 5,   GLUT3↑, 1,   GLUT4↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 8,   IL10↓, 1,   IL10↑, 3,   IL1β↓, 8,   IL6↓, 6,   IL6↑, 1,   Imm↑, 3,   Inflam↓, 18,   JAK2↓, 1,   p‑JAK2↓, 1,   MCP1↓, 1,   NF-kB↓, 8,   NF-kB↑, 1,   PGE2↓, 3,   PGE2↑, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR4↓, 3,   TNF-α↓, 10,   TNF-α↑, 1,   VitD↑, 1,  

Cellular Microenvironment ⓘ

NOX↓, 1,  

Synaptic & Neurotransmission ⓘ

5HT↑, 3,   AChE↓, 7,   BDNF↑, 2,   ChAT↑, 3,   GABA↑, 1,   MAOA↓, 1,   tau↓, 1,   TrkB↑, 1,  

Protein Aggregation ⓘ

Aβ↓, 5,   NLRP3↓, 2,  

Hormonal & Nuclear Receptors ⓘ

testos↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 2,   BioAv↝, 2,   Dose↑, 1,   Dose↝, 5,   eff↑, 6,   Half-Life↓, 1,   Half-Life↝, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 11,   ALP↓, 6,   AST↓, 12,   BG↓, 1,   BMD↑, 2,   BMPs↑, 1,   BP↓, 2,   Calcium↑, 1,   GutMicro↑, 1,   hs-CRP↓, 1,   IL6↓, 6,   IL6↑, 1,   LDH↓, 5,   Mag↑, 1,   VitD↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 3,   AntiDiabetic↑, 3,   cardioP↑, 6,   chemoP↑, 2,   chemoPv↑, 1,   ChemoSideEff↓, 1,   cognitive↓, 1,   cognitive↑, 10,   hepatoP↑, 11,   memory↑, 8,   motorD↑, 4,   neuroP↑, 15,   Obesity↓, 2,   OS↑, 1,   Pain↓, 2,   radioP↑, 1,   RenoP↑, 6,   Risk↓, 1,   Sleep↑, 1,   Strength↑, 1,   toxicity↓, 4,   toxicity↝, 1,   toxicity∅, 1,   Wound Healing↑, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 3,  
Total Targets: 181

Scientific Paper Hit Count for: Catalase, Catalase
18 Thymoquinone
12 Magnetic Fields
9 Quercetin
8 Carvacrol
7 Curcumin
7 Hydrogen Gas
7 Lycopene
7 Silymarin (Milk Thistle) silibinin
6 Silver-NanoParticles
6 Resveratrol
6 Boron
6 Luteolin
6 Rosmarinic acid
5 Propolis -bee glue
5 Selenium NanoParticles
4 Alpha-Lipoic-Acid
4 Betulinic acid
4 Chlorogenic acid
4 Chrysin
4 EGCG (Epigallocatechin Gallate)
4 Ferulic acid
4 Moringa oleifera
4 Sulforaphane (mainly Broccoli)
4 Urolithin
3 Apigenin (mainly Parsley)
3 Ascorbyl Palmitate
3 Melatonin
3 Fisetin
3 Pterostilbene
2 Ashwagandha(Withaferin A)
2 Baicalein
2 Berberine
2 Boswellia (frankincense)
2 Thymol-Thymus vulgaris
2 Celastrol
2 Chemotherapy
2 HydroxyCitric Acid
2 Honokiol
2 Magnetic Field Rotating
2 Piperine
2 Selenite (Sodium)
2 Vitamin C (Ascorbic Acid)
1 5-Aminolevulinic acid
1 Allicin (mainly Garlic)
1 Artemisinin
1 Radiotherapy/Radiation
1 Astaxanthin
1 Aloe anthraquinones
1 Bacopa monnieri
1 Selenium
1 Caffeic acid
1 Capsaicin
1 Exercise
1 Shilajit/Fulvic Acid
1 Ginkgo biloba
1 γ-linolenic acid (Borage Oil)
1 Graviola
1 Orlistat
1 Hydroxycinnamic-acid
1 Magnolol
1 Methylsulfonylmethane
1 Oleuropein
1 HydroxyTyrosol
1 Sesame seeds and Oil
1 Shikonin
1 Taurine
1 5-fluorouracil
1 Ursolic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:46  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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