miR-143 Cancer Research Results

miR-143, miR-143: Click to Expand ⟱
Source:
Type: short RNA molecule
miR-143 and miR-145 (miR-143/145), which are located in a cluster within the 5q32-33 chromosomal region, are downregulated in many types of cancers, including colon cancer and breast cancer.
Scientific Papers found: Click to Expand⟱
133- CUR,    Curcumin inhibits prostate cancer by targeting PGK1 in the FOXD3/miR-143 axis
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
miR-143↑, Curcumin treatment significantly upregulated miR-143 and decreased prostate cancer cell proliferation and migration.
PDK1↓, curcumin treatment inhibited PGK1 expression
FOXD3↑, Curcumin time-dependently upregulated FOXD3, which accounted for the escalating miR-143 levels with the duration of curcumin treatment.
TumCP↓, Furthermore, we showed that silencing miR-143 abrogated the effect of curcumin in inhibiting cell proliferation and migration.
TumCMig↓,
*Inflam↓, pharmaceutical properties of curcumin include antiinflammatory, antioxidant, chemo-preventative, and chemotherapeutic properties
*antiOx↑,
*chemoPv↑,
RadioS↑, underlying mechanism of curcumin in prostate cancer therapy, potentiating the clinical utility of curcumin as a chemo-preventive, chemotherapeutic, radio-, and drug-sensitizing agent.
ChemoSen↑,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

PDK1↓, 1,  

Kinase & Signal Transduction ⓘ

FOXD3↑, 1,  

Transcription & Epigenetics ⓘ

miR-143↑, 1,  

Migration ⓘ

TumCMig↓, 1,   TumCP↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   RadioS↑, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Functional Outcomes ⓘ

chemoPv↑, 1,  
Total Targets: 3

Scientific Paper Hit Count for: miR-143, miR-143
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:461  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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