TfR1/CD71 Cancer Research Results

TfR1/CD71, Transferrin receptor protein 1,: Click to Expand ⟱
Source:
Type: gene/protein
Also called CD71
A protein that in humans is encoded by the TFRC gene. A protein that mediates iron uptake from transferrin into cells.
Transferrin receptor, which can control iron metabolism, is frequently expressed in tumor cells.
As is well known, TfR1 binds to iron-loaded transferrin and plays a pivotal role in cellular uptake of iron as well as ferritin sequesters and stores the cellular iron.


Scientific Papers found: Click to Expand⟱
557- ART/DHA,    Artemisinin and Its Derivatives in Cancer Care
- Review, Var, NA
*BioAv↓, with High fat and high calorie meals
*BioAv↑, DHA dihydroartemisinin have improved bioavailability
Apoptosis↑,
EGFR↓,
CD31↓,
Ki-67↓,
P53↓,
TfR1/CD71↑,
P-gp↓, many artemisinin derivatives act as P-gp inhibitors
PD-1↝, Caution when used with mmunotherapy (PD1/PDL1 inhibitors)

135- CUR,    Curcumin induces apoptosis and protective autophagy in castration-resistant prostate cancer cells through iron chelation
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
TfR1/CD71↑, curcumin enhanced the expression levels of TfR1 and IRP1, indicative of iron deprivation induced by curcumin.
IRP1↑,
IronCh↑,
Casp↑, Curcumin induces caspase-related apoptosis in CRPC cells
eff↑, Inhibition of autophagy increased the cytotoxicity of curcumin

673- EGCG,    Iron Chelation Properties of Green Tea Epigallocatechin-3-Gallate (EGCG) in Colorectal Cancer Cells: Analysis on Tfr/Fth Regulations and Molecular Docking
- in-vitro, CRC, HT-29
IronCh↑,
TfR1/CD71↑, TfR being upregulated and FtH being down-regulated
FTH1↓,

4927- PEITC,    Targeting ferroptosis in osteosarcoma
- Review, OS, NA
AntiCan↑, β-Phenethyl isothiocyanate (PEITC) is widely found in cruciferous vegetables and has anti-cancer potential
BioAv↑, great value in OS treatment owing to its unique biological properties such as low clearance and high bioavailability
Ferroptosis↑, mechanism of action is thought to be linked to ferroptosis
TfR1/CD71↑, uplifting the expression of transferrin receptor 1 (TfR1) and elevating the level of reactive iron.
Iron↑,
ROS↑, PEITC induced oxidative stress. Malondialdehyde (MDA) and ROS, products of lipid peroxidation, were raised and GPX4 was diminished to impair intracellular antioxidant defence systems
MDA↑,
lipid-P↑,
GPx4↓,


Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Ferroptosis↑, 1,   GPx4↓, 1,   Iron↑, 1,   IRP1↑, 1,   lipid-P↑, 1,   MDA↑, 1,   ROS↑, 1,  

Metal & Cofactor Biology ⓘ

FTH1↓, 1,   IronCh↑, 2,   TfR1/CD71↑, 4,  

Cell Death ⓘ

Apoptosis↑, 1,   Casp↑, 1,   Ferroptosis↑, 1,  

DNA Damage & Repair ⓘ

P53↓, 1,  

Migration ⓘ

CD31↓, 1,   Ki-67↓, 1,  

Angiogenesis & Vasculature ⓘ

EGFR↓, 1,  

Barriers & Transport ⓘ

P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

PD-1↝, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   eff↑, 1,  

Clinical Biomarkers ⓘ

EGFR↓, 1,   Ki-67↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,  
Total Targets: 24

Pathway results for Effect on Normal Cells:


Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,  
Total Targets: 2

Scientific Paper Hit Count for: TfR1/CD71, Transferrin receptor protein 1,
1 Artemisinin
1 Curcumin
1 EGCG (Epigallocatechin Gallate)
1 Phenethyl isothiocyanate
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:465  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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