MAOA Cancer Research Results

MAOA, Monoamine Oxidase A: Click to Expand ⟱
Source:
Type: gene/enzyme
Also known as MAO-A, or "Warrior Gene"(associated with increased aggression and impulsivity). This enzyme plays a crucial role in the breakdown of various neurotransmitters, such as serotonin, dopamine, and norepinephrine.
MAOA is commonly overexpressed in prostate cancer, and others.
-MAO-A inhibitors have been proven to be effective antidepressantn
Scientific Papers found: Click to Expand⟱
6378- Eug,    Effects of Eugenol on the Central Nervous System: Its Possible Application to Treatment of Alzheimer's Disease, Depression, and Parkinson's Disease
- Review, AD, NA
*other↑, A body of evidence suggests that eugenol can be used as a drug for treatment of Alzheimer's disease (AD).
*Aβ↓, Eugenol inhibits Aβ-induced excessive influx of calcium ion into neurons that causes neuronal death. Moreover, eugenol possesses an antidepressant-like activity.
*BDNF↑, Eugenol, like other antidepressants, increases expression of brain-derived neurotrophic factor (BDNF) gene in the hippocampus, which is necessary for an antidepressant to exhibit its activity.
*MAOA↑, Furthermore, eugenol inhibits monoamine oxidase A (MAO-A) and may restore monoamines that are decreased in the brain of patients with depression.
*toxicity↓, eugenol is the major ingredient of those ‘major three spices (i.e. clove, cinnamon, and nutmeg)’, it is widely believed safe and used also for a natural food flavor and preservative
*Ca+2↓, Eugenol (≈200 μM) has a blocking activity on Ca++ channels [87], though the mechanism is still unclear.
*antiOx↑, Eugenol has an antioxidative activity. It can scavenge free radicals directly and reduce oxidative stress [96]. Eugenol traps hydroxyl radicals directly [69]. Besides, indirect reduction of ROS by eugenol is known.
*ROS↓,
*lipid-P↓, Eugenol inhibits lipid peroxidation induced by ferrous-ion, ferric-ion, and cumene-hydroperoxide in rat brain homogenates
*neuroP↑, It has been strongly suggested that eugenol has neuroprotective effects against various sorts of inflammatory events.
*PGE2↓, Eugenol has a dose-dependent inhibitory activity on PGE2 production by suppressing gene expression of COX-2, but not of COX-1,
*COX2↓,
*5LO↓, A recent report shows that eugenol has an inhibitory activity on the enzyme 5-lipoxygenase


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   lipid-P↓, 1,   ROS↓, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,  

Migration ⓘ

5LO↓, 1,   Ca+2↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   PGE2↓, 1,  

Synaptic & Neurotransmission ⓘ

BDNF↑, 1,   MAOA↑, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,  

Functional Outcomes ⓘ

neuroP↑, 1,   toxicity↓, 1,  
Total Targets: 13

Scientific Paper Hit Count for: MAOA, Monoamine Oxidase A
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:472  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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