p44 Cancer Research Results

p44, p44/ERK1: Click to Expand ⟱
Source:
Type:
The P44 protein, also known as p44 or p44/ERK1, is a member of the mitogen-activated protein kinase (MAPK) family, specifically the extracellular signal-regulated kinases (ERKs). These proteins play a crucial role in various cellular processes, including proliferation, differentiation, and survival, and are involved in signaling pathways that can influence cancer development and progression

p44 tends to be overexpressed in several hormone–driven and other cancers, correlating with more aggressive disease and poorer prognosis, thereby acting in a protumorigenic manner.
Scientific Papers found: Click to Expand⟱
7019- Fuc,    Fucoidan protects hepatocytes from apoptosis and inhibits invasion of hepatocellular carcinoma by up-regulating p42/44 MAPK-dependent NDRG-1/CAP43
- vitro+vivo, HCC, HUH7
TumCI↓, Fucoidan was found to suppress the invasion of HCC cells through up-regulation of p42/44 MAPK-dependent NDRG-1/CAP43 and partly, under normoxic conditions, through up-regulation of p42/44 MAPK-dependent VMP-1 expression.
p42↑,
p44↑,
MAPK↑,
TumMeta↓, It also significantly decreased liver metastasis in vivo
hepatoP↑, As regards its hepatoprotective effect, fucoidan decreased BA-induced hepatocyte apoptosis as shown by the attenuation of caspase-8, and -7 cleavages and suppression of the mobilization of caspase-8 and Fas associated death domain (FADD) into the dea
*antiOx↑, Fucoidan has also been reported to exert a protective effect on hepatocytes showing anti-oxidative effects against acute liver injury and liver fibrosis
*TumCP↓, Cell proliferation following fucoidan treatment decreased in a dose-dependent manner under both normoxic and hypoxic conditions
Vim↓, fucoidan treatment was found to decrease the expressions of vimentin, E-cadherin, and fibronectin in Huh-7 cells as compared to controls
E-cadherin↓,
Fibronectin↓,
NDRG1↑, Fucoidan enhances the expression of NDRG-1/CAP43 by the p42/44 MAPK pathway
VMP-1↑, Enhanced expression of VMP-1 by fucoidan under normoxic conditions
TumMeta↓, Fucoidan inhibited liver metastasis in an intrahepatic portal vein metastasis model in vivo

87- QC,    Quercetin inhibits prostate cancer by attenuating cell survival and inhibiting anti-apoptotic pathways
- in-vitro, Pca, LNCaP - in-vitro, Pca, DU145 - in-vitro, Pca, PC3
ROS⇅,
BAX↑, quercetin treatment increased BAX levels
PUMA⇅,
β-catenin/ZEB1↓,
Shc↓,
TAp63α↑, DU-145
MAPK↑, DU-145 DU-145
p‑p42↑,
p‑p44↑,
BIM↑, . In androgen-independent PCa cells with mutated p53 (DU-145), quercetin treatment increases cellular BAX levels whereas PUMA and BIM increased


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

VMP-1↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS⇅, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

p42↑, 1,   p‑p42↑, 1,  

Cell Death(tgid=5) ⓘ

BAX↑, 1,   BIM↑, 1,   MAPK↑, 2,   PUMA⇅, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Shc↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TAp63α↑, 1,  

Migration(tgid=13) ⓘ

E-cadherin↓, 1,   Fibronectin↓, 1,   p44↑, 1,   p‑p44↑, 1,   TumCI↓, 1,   TumMeta↓, 2,   Vim↓, 1,   β-catenin/ZEB1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

hepatoP↑, 1,   NDRG1↑, 1,  
Total Targets: 20

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  
Total Targets: 2

Scientific Paper Hit Count for: p44, p44/ERK1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:482  State#:%  Dir#:2
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