PCNA Cancer Research Results

PCNA, Proliferating Cell Nuclear Antigen: Click to Expand ⟱
Source:
Type:
Proliferating Cell Nuclear Antigen (PCNA) is a protein that plays a crucial role in DNA replication and repair. It acts as a processivity factor for DNA polymerase, helping to increase the efficiency of DNA synthesis. PCNA is also involved in various cellular processes, including cell cycle regulation, DNA damage response, and chromatin remodeling.
PCNA is often overexpressed in many types of tumors. This overexpression is associated with increased cell proliferation, which is a hallmark of cancer. The elevated levels of PCNA can serve as a biomarker for tumor growth and progression.
PCNA is called the “ringmaster of the genome” : it regulates the cell cycle and participates in DNA synthesis. PCNA is widely used as a cell proliferation marker in both healthy and malignant tissues.
Scientific Papers found: Click to Expand⟱
4029- FulvicA,  Chemo,    Shilajit mitigates chemotherapeutic drug-induced testicular toxicity: Study on testicular germ cell dynamics, steroidogenesis modulation, and Nrf-2/Keap-1 signaling
- in-vivo, Var, NA
*other↑, Shilajit improves testicular daily production and sperm quality by promoting the conversion of spermatogonia (2C) into spermatids (1C)
*PCNA↑, , stimulating germ cell proliferation (PCNA)
*SOD↑, Shilajit also reduces testicular oxidative stress by increasing antioxidant enzyme activity (SOD) and decreasing lipid peroxidation (LPO)
*lipid-P↓,
*NRF2↑, effects are mediated by upregulation of the antioxidant protein Nrf-2 and downregulation of Keap-1.
*Keap1↓,
*chemoP↑, enhance fertility in cases of testicular damage caused by chemotherapeutic drugs.

6436- T4O,    Terpinen-4-ol suppresses proliferation and motility of cutaneous squamous cell carcinoma cells by enhancing calpain-2 expression
- in-vitro, Melanoma, A431
TumCP↓, T4O treatment inhibited cSCC proliferation, clonogenicity, migration, and invasion while inducing apoptosis and suppressing the EMT pathway.
TumCMig↓,
TumCI↓,
Apoptosis↑,
EMT↓,
AntiTum↑, T4O administration also inhibited cSCC tumorigenesis in the xenograft tumor model.
cal2↑, significant upregulation of calpain-2 expression in T4O-treated cSCC cells.
cl‑β-catenin/ZEB1↑, promoted proteolytic cleavage of β-catenin and caspase-12, two calpain-2 target proteins.
cl‑Casp12↑,
Bcl-2↓, decrease in the expression of Bcl-2 (an anti-apoptotic marker), cyclin-D1 (a G1 checkpoint protein), and CDK2
cycD1/CCND1↓,
CDK2↓,
BAX↑, increase in Bax expression (a pro-apoptotic marker) in cSCC cell lines
TumCCA↑, promoting G1-phase arrest and inducing apoptosis.
selectivity↑, In contrast, T4O treatment did not affect wound closure rates in normal WS1 fibroblasts
N-cadherin↓, T4O treated cSCC cell lines showed prominently decreased N-cadherin expression and upregulated E-cadherin expression
E-cadherin↑,
Ki-67↓, notable decrease in the expression levels of two proliferation markers, Ki67 and PCNA, in T4O-treated mice
PCNA↑,


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   cl‑Casp12↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

PCNA↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   cycD1/CCND1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,  

Migration(tgid=13) ⓘ

cal2↑, 1,   E-cadherin↑, 1,   Ki-67↓, 1,   N-cadherin↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,   cl‑β-catenin/ZEB1↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

Ki-67↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,  
Total Targets: 20

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Keap1↓, 1,   lipid-P↓, 1,   NRF2↑, 1,   SOD↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

PCNA↑, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoP↑, 1,  
Total Targets: 7

Scientific Paper Hit Count for: PCNA, Proliferating Cell Nuclear Antigen
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

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